Lee SY. Jejunoileal side-to-side anastomosis as a promising option for type 2 diabetes. World J Diabetes 2025; 16(4): 103546 [DOI: 10.4239/wjd.v16.i4.103546]
Corresponding Author of This Article
Sang Yeoup Lee, Family Medicine and Biomedical Research Institute, Pusan National University Yangsan Hospital, Geumo-ro 20, Mulgeum-eup, Yangsan 50612, South Korea. saylee@pnu.edu
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Apr 15, 2025; 16(4): 103546 Published online Apr 15, 2025. doi: 10.4239/wjd.v16.i4.103546
Jejunoileal side-to-side anastomosis as a promising option for type 2 diabetes
Sang Yeoup Lee
Sang Yeoup Lee, Family Medicine and Biomedical Research Institute, Pusan National University Yangsan Hospital, Yangsan 50612, South Korea
Sang Yeoup Lee, Medical Education, Pusan National University School of Medicine, Yangsan 50760, South Korea
Author contributions: Lee SY contributed to data collection, study design, data analysis, and interpretation and wrote, read, and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sang Yeoup Lee, Family Medicine and Biomedical Research Institute, Pusan National University Yangsan Hospital, Geumo-ro 20, Mulgeum-eup, Yangsan 50612, South Korea. saylee@pnu.edu
Received: November 25, 2024 Revised: January 20, 2025 Accepted: February 7, 2025 Published online: April 15, 2025 Processing time: 98 Days and 5.5 Hours
Abstract
In this editorial, I discuss the article by Wang et al, published in the World Journal of Diabetes, which explores jejunoileal side-to-side anastomosis as a novel surgical intervention for type 2 diabetes mellitus (T2DM). T2DM, often associated with obesity, remains a global health challenge, as sustained remission is difficult to achieve with conventional pharmacological therapy. Jejunoileal anastomosis offers a promising alternative, particularly for patients with normal or relatively high body mass index, and addresses the unique challenges posed by diverse patient populations. This procedure preserves gastric anatomy while simultaneously improving metabolic parameters, such as glycemic control, lipid profiles, and pancreatic β-cell function. Unlike traditional metabolic surgeries that involve permanent anatomical alterations, this approach provides advantages such as reversibility, shorter operative times, and minimal nutritional complications, making it appealing to patients for whom conventional bariatric surgery is unsuitable. Advances in gut hormone physiology and incretin modulation support these findings. This innovative approach represents a potential paradigm shift in T2DM treatment, offering insights into the evolving role of surgical interventions in metabolic regulation. While early findings show promising diabetes remission rates and metabolic improvements at six months post-surgery, further studies with longer follow-up periods and broader patient cohorts are required.
Core Tip: This editorial examines jejunoileal side-to-side anastomosis as a novel surgical approach for type 2 diabetes mellitus. It highlights the role of this surgical approach in modulating glucagon-like peptide-1, improving β-cell function, and preserving gastric anatomy, thereby offering a promising alternative for patients with type 2 diabetes mellitus and a relatively high body mass index.
