Zheng GJ, Fang ZE, Zhou BY, Zuo L, Chen X, Liu ML, Yu L, Jing CX, Hao G. DNA methylation in the association between pesticide exposures and type 2 diabetes. World J Diabetes 2025; 16(2): 99200 [DOI: 10.4239/wjd.v16.i2.99200]
Corresponding Author of This Article
Guang Hao, MD, PhD, Associate Professor, Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, No. 283 Jianghai Avenue, Guangzhou 510632, Guangdong Province, China. haoguang2015@hotmail.com
Research Domain of This Article
Public, Environmental & Occupational Health
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Feb 15, 2025; 16(2): 99200 Published online Feb 15, 2025. doi: 10.4239/wjd.v16.i2.99200
DNA methylation in the association between pesticide exposures and type 2 diabetes
Guang-Jun Zheng, Zheng-Er Fang, Bi-Ying Zhou, Lei Zuo, Xia Chen, Ming-Liang Liu, Lei Yu, Chun-Xia Jing, Guang Hao
Guang-Jun Zheng, Zheng-Er Fang, Bi-Ying Zhou, Lei Zuo, Xia Chen, Ming-Liang Liu, Chun-Xia Jing, Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China
Lei Yu, Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China
Chun-Xia Jing, Guangdong Key Laboratory of Environmental Exposure and Health, Jinan University, Guangzhou 510632, Guangdong Province, China
Guang Hao, Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510632, Guangdong Province, China
Co-first authors: Guang-Jun Zheng and Zheng-Er Fang.
Author contributions: Zheng GJ and Fang ZE should be considered as joint first authors because they contributed equally to this study; All authors contributed to the study conception and design; Hao G and Jing CX were responsible for conceptualization, methodology, supervision, and editing sections; Zheng GJ and Fang ZE tasked with the literature search, data collection, investigation, visualization, and original draft writing sections; Zhou BY, Zuo L, Chen X, Liu ML and Yu L reviewed the article and made helpful suggestions; All authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang Hao, MD, PhD, Associate Professor, Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, No. 283 Jianghai Avenue, Guangzhou 510632, Guangdong Province, China. haoguang2015@hotmail.com
Received: July 16, 2024 Revised: September 30, 2024 Accepted: November 21, 2024 Published online: February 15, 2025 Processing time: 166 Days and 22.1 Hours
Abstract
BACKGROUND
Numerous epidemiological studies have found that pesticide exposure is associated with the incidence of type 2 diabetes (T2D); however, the underlying mechanisms remain unknown. DNA methylation may play a role in this process.
AIM
To identify the genes associated with pesticide exposure and T2D by reviewing the current literature.
METHODS
We systematically searched PubMed and Embase for relevant studies that examined the association between pesticide exposure and DNA methylation, and studies on DNA methylation and T2D through January 15, 2024.
RESULTS
We identified six genes (Alu, CABLES1, CDH1, PDX1, PTEN, PTPRN2) related to pesticide exposure and T2D. We also suggested future research directions to better define the role of DNA methylation in the association between pesticide exposure and T2D.
CONCLUSION
DNA methylation of specific genes may play a vital role in the association between pesticide exposure and T2D.
Core Tip: Previous studies have reported an association between pesticide exposure and the incidence of type 2 diabetes (T2D), but the underlying mechanisms have not been fully elucidated. In this article, we speculated that DNA methylation may be associated with pesticide exposure and T2D. We systematically reviewed the current literature to identify genes that are not only associated with pesticide exposure but also with T2D. Six genes (Alu, CABLES1, CDH1, PDX1, PTEN, PTPRN2) were identified.
