Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2025; 16(1): 99526
Published online Jan 15, 2025. doi: 10.4239/wjd.v16.i1.99526
Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes
Ji-Kui Wang, Di Zhang, Jin-Feng Wang, Wan-Lin Lu, Jing-Yuan Wang, Shi-Feng Liang, Ran Liu, Jing-Xin Jiang, Hong-Tao Li, Xuan Yang
Ji-Kui Wang, Jin-Feng Wang, Wan-Lin Lu, Jing-Yuan Wang, Shi-Feng Liang, Ran Liu, Jing-Xin Jiang, Hong-Tao Li, Xuan Yang, Department of General Thoracic Surgery, Liaoning Electric Power Center Hospital, Shenyang 110000, Liaoning Province, China
Di Zhang, Department of Health Management Center, Liaoning Electric Power Center Hospital, Shenyang 110000, Liaoning Province, China
Co-first authors: Ji-Kui Wang and Di Zhang.
Co-corresponding authors: Hong-Tao Li and Xuan Yang.
Author contributions: Wang JK and Zhang D searched data, organized information, and drafted the manuscript; Wang JF, Lu WL, Wang JY, Liang SF, Liu R and Jiang JX screening and sorting information; Yang X and Li HT inspiration, editing and critically revising the manuscript for intellectual content. Wang JK and Zhang D contributed equally to this work as co-first authors. At the beginning of the study, Li HT as the decision maker, and Yang X, the corresponding author, jointly formulated the research plan and carried out the experimental design. Then, in the ethics link, Li HT completed the writing of the ethics document and cooperated with the ethics committee of my unit to conduct the ethical review until the ethics was passed, laying a foundation for the smooth progress of this research. In the process of data analysis, the author Li HT participated in data statistics and data proofreading. In the process of manuscript revision, author Li HT was able to cooperate with corresponding author Yang X to respond to the valuable questions raised by reviewers, correct and proofread the manuscript, process the revision and resubmit the revised manuscript until the manuscript was accepted. Considering the contribution of the author Li HT in this manuscript, the team decided to change the author ranking of Li HT from the first author to the co-corresponding author after collective discussion.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Liaoning Electric Power Center Hospital.
Informed consent statement: All authors of this study were informed and consented to publication.
Conflict-of-interest statement: The authors have no relevant financial or non-financial interests to disclose.
Data sharing statement: This study can provide the data covered in the paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xuan Yang, MMed, Chief Doctor, Department of General Thoracic Surgery, Liaoning Electric Power Center Hospital, No. 2 Wanghu Road, Heping District, Shenyang 110000, Liaoning Province, China. yangxuandl@163.com
Received: July 24, 2024
Revised: September 4, 2024
Accepted: November 8, 2024
Published online: January 15, 2025
Processing time: 128 Days and 16.4 Hours
Abstract
BACKGROUND

At present, the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent, to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes, the report is as follows.

AIM

To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus (T2DM).

METHODS

We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral anastomosis. Metabolic indicators were collected preoperatively, as well as at 3 and 6 months postoperative. The metabolic indicators analyzed included body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG), 2-hour blood glucose (PBG), glycated hemoglobin (HbA1c), fasting C-peptide, 2-hour C-peptide (PCP), fasting insulin (Fins), 2-hour insulin (Pins), insulin resistance index (HOMA-IR), β Cellular function index (HOMA-β), alanine aminotransferase, aspartate aminotransferase, serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein, and uric acid (UA) levels.

RESULTS

SBP, DBP, PBG, HbA1c, LDL-C, and TG were all significantly lower 3 months postoperative vs preoperative values; body weight, BMI, SBP, DBP, FBG, PBG, HbA1c, TC, TG, UA, and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months; and PCP, Fins, Pins, and HOMA-β were all significantly higher 6 months postoperative vs at 3 months (all P < 0.05).

CONCLUSION

Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

Keywords: Metabolic diseases; Type 2 diabetes; Jejunoileal side-to-side anastomosis; Glycolipid metabolism; Islet function

Core Tip: This study investigates the impact of jejunal ileal side to side anastomosis on metabolic parameters in patients with type 2 diabetes. The procedure showed significant improvements in patients' metabolic indicators such as body mass index, blood pressure, blood glucose, insulin resistance index, and cholesterol levels at 3 and 6 months post-surgery. This suggests that jejunal ileal side to side anastomosis could be an effective treatment for managing type 2 diabetes and improving metabolic health.