Xiong LY, Zhao W, Hu FQ, Zhou XM, Zheng YJ. Ubiquitination in diabetes and its complications: A perspective from bibliometrics. World J Diabetes 2025; 16(1): 100099 [DOI: 10.4239/wjd.v16.i1.100099]
Corresponding Author of This Article
Yu-Jiao Zheng, PhD, Affiliate Associate Professor, College of Traditional Chinese Medicine, Anhui University of Chinese Medicine, No. 1 Qianjiang Road, Yaohai District, Hefei 230012, Anhui Province, China. zhengyujiao@ahtcm.edu.cn
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Scientometrics
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Li-Yuan Xiong, Wei Zhao, Fa-Quan Hu, Xue-Mei Zhou, Yu-Jiao Zheng, College of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230012, Anhui Province, China
Co-first authors: Li-Yuan Xiong and Wei Zhao.
Author contributions: Xiong LY conducted the bibliometric analysis and composed the manuscript. Zheng YJ conceptualized the study and oversaw data retrieval by Xiong LY. Xiong LY and Zhao W performed the statistical analysis. Xiong LY, Zhao W, Hu FQ, and Zheng YJ critically reviewed the manuscript. Zheng YJ and Zhou XM provided overall supervision and guidance for revisions throughout the process. Li-Yuan Xiong and Wei Zhao contributed equally to the research and writing of this paper and are designated as co-first authors; All authors contributed to and approved the final version of the article.
Supported by Key Project of Anhui Provincial Education Department, No. 2022AH050486; and 2021 High-level Talent Introduction Scientific Project of Anhui University of Chinese Medicine, No. 2022rczd005.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Jiao Zheng, PhD, Affiliate Associate Professor, College of Traditional Chinese Medicine, Anhui University of Chinese Medicine, No. 1 Qianjiang Road, Yaohai District, Hefei 230012, Anhui Province, China. zhengyujiao@ahtcm.edu.cn
Received: August 8, 2024 Revised: September 27, 2024 Accepted: November 12, 2024 Published online: January 15, 2025 Processing time: 114 Days and 21.9 Hours
Abstract
BACKGROUND
Diabetes has a substantial impact on public health, highlighting the need for novel treatments. Ubiquitination, an intracellular protein modification process, is emerging as a promising strategy for regulating pathological mechanisms. We hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications, and that understanding these mechanisms can lead to new therapeutic approaches.
AIM
To uncover the research trends and advances in diabetes ubiquitination and its complications, we conducted a bibliometric analysis.
METHODS
Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core Collection. Visual mapping analysis was conducted using the CiteSpace software.
RESULTS
We gathered 791 articles published over the past 23 years, focusing on ubiquitination in diabetes and its associated complications. These articles originated from 54 countries and 386 institutions, with China as the leading contributor. Shanghai Jiao Tong University has the highest number of publications in this field. The most prominent authors contributing to this research area include Wei-Hua Zhang, with Zhang Y being the most frequently cited author. Additionally, The Journal of Biological Chemistry is noted as the most cited in this field. The predominant keywords included expression, activation, oxidative stress, phosphorylation, ubiquitination, degradation, and insulin resistance.
CONCLUSION
The role of ubiquitination in diabetes and its complications, such as diabetic nephropathy and cardiomyopathy, is a key research focus. However, these areas require further investigations.
Core Tip: Ubiquitination, as a crucial protein modification mechanism, plays a key regulatory role in the pathological processes of diabetes. To gain insights into research trends and future directions in the field of diabetes and ubiquitination, we conducted a systematic bibliometric analysis of relevant literature from 2001 to 2023. Through this analysis, we aim to break through traditional treatments and explore novel and effective therapeutic approaches.
