Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 15, 2024; 15(8): 1824-1828
Published online Aug 15, 2024. doi: 10.4239/wjd.v15.i8.1824
Vitamin D and selenium for type 2 diabetes mellitus with Hashimoto’s thyroiditis: Dosage and duration insights
Yun-Feng Yu, Xue-Li Shangguan, Dan-Ni Tan, Li-Na Qin, Rong Yu
Yun-Feng Yu, Xue-Li Shangguan, Dan-Ni Tan, Li-Na Qin, Rong Yu, School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China
Co-first authors: Yun-Feng Yu and Xue-Li Shangguan.
Author contributions: Yu YF, Shangguan XL, Tan DN, Qin LN, Yu R Yu YF and Shangguan XL analyzed the literature and wrote the letter; Tan DN and Qin LN performed the research mentioned in the letter; Yu R proposed the idea and revised the letter; All authors have read and approved the final manuscript. Yu YF and Shangguan XL have made equal contributions to this work as co-first authors for two reasons. Firstly, Yu YF and Shangguan XL made contributions of equal significance throughout the research process. The choice of these researchers as co-first authors acknowledges and respects this equal contribution. Secondly, the research was a collaborative effort, and co-first authorship accurately reflects the distribution of responsibilities and the substantial time and effort invested in completing the study and the resulting paper. In summary, designating Yu YF and Shangguan XL as co-first authors are appropriate for our manuscript as it faithfully reflects our team's collaborative ethos, equal contributions, and diversity.
Supported by the Discipline Construction Project of Hunan University of Chinese Medicine, No. 22JBZ002.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Rong Yu, MD, PhD, Full Professor, School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Hanpu Science and Education Park, Yuelu District, Changsha 410208, Hunan Province, China. yurong196905@163.com
Received: May 2, 2024
Revised: June 5, 2024
Accepted: June 28, 2024
Published online: August 15, 2024
Processing time: 85 Days and 0.8 Hours
Abstract

This letter discusses the publication by Feng et al. Iodine, selenium, and vitamin D are closely associated with thyroid hormone production in humans; however, the efficacy of selenium and vitamin D supplementation for type 2 diabetes mellitus (T2DM) patients with Hashimoto’s thyroiditis (HT) remains controversial. In the retrospective study we discuss herein, the authors highlighted significant improvements in thyroid function, thyroid antibodies, blood glucose, and blood lipid in T2DM patients with HT following addition of vitamin D and selenium to their antidiabetic regimens, underscoring the value of these supplements. Our team is currently engaged in research exploring the relationship between micronutrients and HT, and we have obtained invaluable insights from the aforementioned study. Based on this research and current literature, we recommend a regimen of 4000 IU/day of vitamin D and 100-200 μg/day of selenium for over three months to six months for patients with HT, particularly for those with concurrent T2DM.

Keywords: Vitamin D, Selenium, Type 2 diabetes mellitus, Hashimoto’s thyroiditis, Dosage, Duration

Core Tip: Supplementation with vitamin D and selenium shows promise in improving the prognosis of type 2 diabetes mellitus (T2DM) and Hashimoto's thyroiditis (HT). Despite controversies surrounding their efficacy, a retrospective study discussed in this letter reveals significant benefits from adding these supplements to antidiabetic regimens. Based on this research and current literature, we recommend a regimen of 4000 IU/day of vitamin D and 100-200 μg/day of selenium for over three to six months for patients with HT, particularly for those with concurrent T2DM.