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World J Diabetes. Jul 15, 2024; 15(7): 1448-1460
Published online Jul 15, 2024. doi: 10.4239/wjd.v15.i7.1448
Obstructive sleep apnea: Overlooked comorbidity in patients with diabetes
Eric D Tenda, Joshua Henrina, Jin H Cha, Muhammad R Triono, Ersananda A Putri, Dahliana J Aristy, Dicky L Tahapary
Eric D Tenda, Joshua Henrina, Jin H Cha, Muhammad R Triono, Ersananda A Putri, Dahliana J Aristy, Division of Respirology and Critical Care, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, DKI Jakarta, Jakarta Pusat 10430, Indonesia
Eric D Tenda, Head of Research Group Artificial Intelligence and Digital Health, Indonesian Medical Education and Research Institute, Faculty of Medicine University of Indonesia, DKI Jakarta, Jakarta Pusat 10430, Indonesia
Dicky L Tahapary, Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, DKI Jakarta, Jakarta Pusat 10430, Indonesia
Author contributions: Tenda ED and Henrina J conceptualized and wrote the original draft; Cha JH, Triono MR, Putri EA, Aristy DJ, Tahapary DL revised the draft; Triono MR, Cha JH, and Putri EA prepared the Tables; Putri EA prepared the Figure; Tahapary DL supervised the manuscript. All authors approved the manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors who contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Joshua Henrina, MD, Research Assistant, Division of Respirology and Critical Care, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Pangeran Diponegoro No. 71 RW.5, Kenari, Kec. Senen, Kota Jakarta Pusat, DKI Jakarta, Jakarta Pusat 10430, Indonesia. joshuahenrina@gmail.com
Received: December 31, 2023
Revised: May 8, 2024
Accepted: June 6, 2024
Published online: July 15, 2024
Processing time: 189 Days and 15.9 Hours
Abstract

In this review article, we explore the interplay between obstructive sleep apnea (OSA) and type 2 diabetes mellitus (T2DM), highlighting a significant yet often overlooked comorbidity. We delve into the pathophysiological links between OSA and diabetes, specifically how OSA exacerbates insulin resistance and disrupts glucose metabolism. The research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related complications. Emphasizing the importance of comprehensive management, including weight control and positive airway pressure therapy, the study advocates integrated approaches to improve outcomes for patients with T2DM and OSA. This review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

Keywords: Obstructive sleep apnea; Type 2 diabetes mellitus; Macrovascular; Mic-rovascular; Weight loss; Positive airway pressure

Core Tip: A comprehensive management strategy for type 2 diabetes mellitus should include the recognition and treatment of obstructive sleep apnea (OSA), one of the most prevalent comorbidities in these patients. Addressing OSA is crucial for optimizing overall diabetes care and patient outcomes.