Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1212
Revised: February 27, 2024
Accepted: April 30, 2024
Published online: June 15, 2024
Processing time: 154 Days and 5.4 Hours
The intricate relationship between type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) presents a challenge in understanding the significance of va
To elucidate the roles and diagnostic values of α2-macroglobulin (α2-MG), podo
From December 2018 to December 2020, 203 T2DM patients were enrolled in the study. Of these, 115 were diagnosed with DN (115 patients), while the remaining 88 patients were classified as non-DN. The urinary levels of α2-MG, PCX, and AFU and the serum concentrations RBP-4 and CysC were measured in conjunc
After adjustments for age and gender, significant positive correlations were ob
This study underscores the diagnostic significance of α2-MG, PCX, and AFU in the development of DN. The bio
Core Tip: This study elucidates the diagnostic value of α2-macroglobulin (α2-MG), podocalyxin (PCX), α-L-fucosidase (AFU), retinol-binding protein-4 (RBP-4), and cystatin C (CysC) in type 2 diabetes mellitus and diabetic nephropathy (DN). It reveals that these biomarkers, especially urinary albumin to creatinine ratio (UACR), are strongly correlated with renal damage indicators. The research demonstrates the superior diagnostic capability of UACR for DN, while highlighting the importance of α2-MG, PCX, AFU, RBP-4, and CysC as complementary diagnostic tools. These findings provide valuable insights into the mechanisms of DN and enhance diagnostic accuracy in clinical practice.