Zhou T, Fang YL, Tian TT, Wang GX. Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies. World J Diabetes 2024; 15(6): 1111-1121 [DOI: 10.4239/wjd.v15.i6.1111]
Corresponding Author of This Article
Gui-Xia Wang, PhD, Chief Physician, Professor, Department of Endocrinology and Metabolism, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun 130021, Jilin Province, China. gwang168@jlu.edu.cn
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jun 15, 2024; 15(6): 1111-1121 Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1111
Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies
Tong Zhou, Yi-Lin Fang, Tian-Tian Tian, Gui-Xia Wang
Tong Zhou, Gui-Xia Wang, Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Tong Zhou, Yi-Lin Fang, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Tong Zhou, Yi-Lin Fang, National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, Jilin University, Changchun 130021, Jilin Province, China
Tian-Tian Tian, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Wang GX designed the review; Zhou T performed the literature revision, collected the data, and wrote the manuscript; Fang YL and Tian TT reviewed, and edited the manuscript; All authors have read and approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 82100883; and the Research Project of Educational Commission of Jilin Province of China, No. JJKH20231214KJ.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Gui-Xia Wang, PhD, Chief Physician, Professor, Department of Endocrinology and Metabolism, The First Hospital of Jilin University, No. 1 Xinmin Street, Chaoyang District, Changchun 130021, Jilin Province, China. gwang168@jlu.edu.cn
Received: January 25, 2024 Revised: February 29, 2024 Accepted: April 15, 2024 Published online: June 15, 2024
Abstract
Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease. Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes. With the development of immunological technology, many studies have shown that diabetic nephropathy is an immune complex disease, and that most patients have immune dysfunction. However, the immune response associated with diabetic nephropathy and autoimmune kidney disease, or caused by ischemia or infection with acute renal injury, is different, and has a com-plicated pathological mechanism. In this review, we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism, to provide guidance and advice for early intervention and treatment of diabetic nephropathy.
Core Tip: Diabetic kidney disease (DKD) is a complex immune disease, whose occurrence and development are related to immune inflammatory factors. Currently, the immune process of DKD is mainly regulated by immune cells, inflammatory bodies, immunoglobulins, and complements; thus, interrupting its related regulatory pathways is of great clinical significance.
