Al-Suhaimi EA, Al-Rubaish AA. Interplay of serum biomarkers bilirubin and γ-glutamyltranspeptidase in predicting cardiovascular complications in type-2 diabetes mellitus. World J Diabetes 2024; 15(6): 1074-1078 [DOI: 10.4239/wjd.v15.i6.1074]
Corresponding Author of This Article
Ebtesam Abdullah Al-Suhaimi, PhD, Full Professor, Scientific Research and Innovation, Imam Abdulrahman Bin Faisal University, King Faisal Street, Coastal Road, Dammam 31441, Saudi Arabia. ealsuhaimi@iau.edu.sa
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jun 15, 2024; 15(6): 1074-1078 Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1074
Interplay of serum biomarkers bilirubin and γ-glutamyltranspeptidase in predicting cardiovascular complications in type-2 diabetes mellitus
Ebtesam Abdullah Al-Suhaimi, Abdullah Ahmed Al-Rubaish
Ebtesam Abdullah Al-Suhaimi, Scientific Research and Innovation, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia
Ebtesam Abdullah Al-Suhaimi, King Abdulaziz and his Companions Foundation for Giftedness and Creativity “Mawhiba”, Riyadh 11372, Saudi Arabia
Abdullah Ahmed Al-Rubaish, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia
Author contributions: Al-Suhaimi EA designed and drafted the first version; Al-Rubaish AA drafted and edited the second draft. All authors read and approved the final draft of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ebtesam Abdullah Al-Suhaimi, PhD, Full Professor, Scientific Research and Innovation, Imam Abdulrahman Bin Faisal University, King Faisal Street, Coastal Road, Dammam 31441, Saudi Arabia. ealsuhaimi@iau.edu.sa
Received: December 22, 2023 Revised: April 7, 2024 Accepted: April 11, 2024 Published online: June 15, 2024
Abstract
This editorial synthesizes insights from a series of studies examining the interplay between metabolic and oxidative stress biomarkers in cardiovascular disease (CVD), focusing particularly on type-2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS). The central piece of this synthesis is a study that investigates the balance between oxidative stress and antioxidant systems in the body through the analysis of serum bilirubin and γ-glutamyltranspeptidase (γ-GGT) levels in T2DM patients with ACS. This study highlights serum bilirubin as a protective antioxidant factor, while elevated γ-GGT levels indicate increased oxidative stress and correlate with major adverse cardiovascular events. Complementary to this, other research contributions reveal γ-GGT’s role as a risk factor in ACS, its association with cardiovascular mortality in broader populations, and its link to metabolic syndrome, further elucidating the metabolic dysregulation in CVDs. The collective findings from these studies underscore the critical roles of γ-GGT and serum bilirubin in cardiovascular health, especially in the context of T2DM and ACS. By providing a balanced view of the body’s oxidative and antioxidative mechanisms, these insights suggest potential pathways for targeted interventions and improved prognostic assessments in patients with T2DM and ACS. This synthesis not only corroborates the pivotal role of γ-GGT in cardiovascular pathology but also introduces the protective potential of antioxidants like bilirubin, illuminating the complex interplay between T2DM and heart disease. These studies collectively underscore the critical roles of serum bilirubin and γ-GGT as biomarkers in cardiovascular health, particularly in T2DM and ACS contexts, offering insights into the body’s oxidative and antioxidative mechanisms. This synthesis of research supports the potential of these biomarkers in guiding therapeutic strategies and improving prognostic assessments for patients with T2DM and some CVD.
Core Tip: This editorial delves into the predictive value of serum biomarkers such as bilirubin and γ-glutamyltranspeptidase in the context of type-2 diabetes mellitus with concurrent acute coronary syndrome. Highlighted findings from current research underscore the inverse correlation between these biomarkers and the incidence of major adverse cardiovascular events, advocating their utility in risk stratification and clinical management of such patients.
