Lei XT, Pu DL, Shan G, Wu QN. Atorvastatin ameliorated myocardial fibrosis by inhibiting oxidative stress and modulating macrophage polarization in diabetic cardiomyopathy. World J Diabetes 2024; 15(6): 1070-1073 [DOI: 10.4239/wjd.v15.i6.1070]
Corresponding Author of This Article
Qi-Nan Wu, MD, Chief Physician, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People's Hospital of Dazu, No. 1073 Second Ring South Road, Tangxiang Street, Dazu District, Chongqing 402360, China. wqn11@126.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Jun 15, 2024; 15(6): 1070-1073 Published online Jun 15, 2024. doi: 10.4239/wjd.v15.i6.1070
Atorvastatin ameliorated myocardial fibrosis by inhibiting oxidative stress and modulating macrophage polarization in diabetic cardiomyopathy
Xiao-Tian Lei, Dan-Lan Pu, Geng Shan, Qi-Nan Wu
Xiao-Tian Lei, Department of Endocrinology, The First Affiliated Hospital of the Third Military Medical University (Army Medical University), Chongqing 400038, China
Dan-Lan Pu, Department of Endocrinology, Chongqing Yubei District People's Hospital, Chongqing 400030, China
Geng Shan, Qi-Nan Wu, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People's Hospital of Dazu, Chongqing 402360, China
Author contributions: Lei XT, Dan-Lan Pu, Geng Shan, and Wu QN contributed to this manuscript; Lei XT and Dan-Lan Pu designed the overall concept and outline of themanuscript; Wu QN and Geng Shan contributed to the discussion and design of the manuscript; Lei XT, Dan-Lan Pu, Geng Shan, and Wu QN contributed to the manuscriptwriting and editing, illustrations, and review of literature. All authors reviewed and approved the final draft of the paper.
Supported byNational Natural Science Foundation of China, No. 82000792; and General project of Chongqing Natural Science Foundation, No. cstc2020jcyj-msxm0409.
Conflict-of-interest statement: The authors have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Nan Wu, MD, Chief Physician, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People's Hospital of Dazu, No. 1073 Second Ring South Road, Tangxiang Street, Dazu District, Chongqing 402360, China. wqn11@126.com
Received: December 13, 2023 Revised: March 7, 2024 Accepted: April 7, 2024 Published online: June 15, 2024 Processing time: 181 Days and 8.4 Hours
Abstract
In this editorial, we commented on the article published in the recent issue of the World Journal of Diabetes. Diabetic cardiomyopathy (DCM) is characterized by myocardial fibrosis, ventricular hypertrophy and diastolic dysfunction in diabetic patients, which can cause heart failure and threaten the life of patients. The pathogenesis of DCM has not been fully clarified, and it may involve oxidative stress, inflammatory stimulation, apoptosis, and autophagy. There is lack of effective therapies for DCM in the clinical practice. Statins have been widely used in the clinical practice for years mainly to reduce cholesterol and stabilize arterial plaques, and exhibit definite cardiovascular protective effects. Studies have shown that statins also have anti-inflammatory and antioxidant effects. We were particularly concerned about the recent findings that atorvastatin alleviated myocardial fibrosis in db/db mice by regulating the antioxidant stress and anti-inflammatory effects of macrophage polarization on diabetic myocardium, and thereby improving DCM.
Core Tip: Satins are widely used in cardiovascular disease because of their effective effects to reduce cholesterol and stabilize arterial plaques. Reasonable statins contribute to reducing the morbidity rate of cardiovascular events. Studies have shown that statins also have anti-inflammatory and antioxidant effects. Moreover, the researchers have found anti-inflammatory and anti-oxidative stress effects of atorvastatin by regulating macrophage polarization to alleviated myocardial fibrosis and ameliorated diabetic cardiomyopathy in db/db mice.
