Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2024; 15(5): 810-813
Published online May 15, 2024. doi: 10.4239/wjd.v15.i5.810
Impact of tibial transverse transport in tissue regeneration and wound healing with perspective on diabetic foot ulcers
Sulagna Mukherjee, Seung-Soon Im
Sulagna Mukherjee, Seung-Soon Im, Department of Physiology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea
Author contributions: Mukherjee S and Im SS contributed to this paper; Im SS designed the overall concept and outline of the manuscript; Mukherjee S contributed to the discussion and design of the manuscript; Mukherjee S and Im SS contributed to the writing, and editing the manuscript, illustrations, and review of literature.
Supported by Grants of the Korea Research Foundation, an NRF Grant Funded by the Korea Government, No. NRF-2023R1A2C3003717.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seung-Soon Im, PhD, Professor, Department of Physiology, Keimyung University School of Medicine, 1095 Dalgubeol-daero, Daelseo-gu, Daegu 42601, Republic of Korea. ssim73@kmu.ac.kr
Received: November 29, 2023
Peer-review started: November 29, 2023
First decision: January 25, 2024
Revised: February 1, 2024
Accepted: March 8, 2024
Article in press: March 8, 2024
Published online: May 15, 2024
Processing time: 163 Days and 8.7 Hours
Abstract

In this editorial, we comment on an article by Liao et al published in the current issue of the World Journal of Diabetes. We focus on the clinical significance of tibial transverse transport (TTT) as an effective treatment for patients with diabetic foot ulcers (DFU). TTT has been associated with tissue regeneration, improved blood circulation, reduced amputation rates, and increased expression of early angiogenic factors. Mechanistically, TTT can influence macrophage polarization and growth factor upregulation. Despite this potential, the limitations and conflicting results of existing studies justify the need for further research into its optimal application and development. These clinical implications highlight the efficacy of TTT in recalcitrant DFU and provide lasting stimuli for tissue re-generation, and blood vessel and bone marrow improvement. Immunomodulation via systemic responses contributes to its therapeutic potential. Future studies should investigate the underlying molecular mechanisms to enhance our understanding and the efficacy of TTT. This manuscript emphasizes the potential of TTT in limb preservation and diabetic wound healing and suggests avenues for preventive measures against limb amputation in diabetes and peripheral artery disease. Here, we highlight the clinical significance of the TTT and its importance in healing DFU to promote the use of this technique in tissue regeneration.

Keywords: Diabetes foot ulcer; Tibial transverse transport; Foot surgery; Wound healing; Tissue regeneration

Core Tip: Tibial transverse transport (TTT) operation is an effective modern-day technique of treating diabetic foot ulcers (DFU) with a high rate of healing and limb savage compared to conventional surgery. TTT significantly improves blood circulation, release of angiogenic factors and reduces recurrence rate of DFU.