Metabolic syndrome’s new therapy: Supplement the gut microbiome

Abstract

This letter to the editor discusses the publication on gut microbiome supplementation as therapy for metabolic syndrome. Gut microbiome dysbiosis disrupts intestinal bacterial homeostasis and is related to chronic inflammation, insulin resistance, cardiovascular diseases, type 2 diabetes mellitus, and obesity. Previous research has found that increasing the abundance of beneficial microbiota in the gut modulates metabolic syndrome by reducing chronic inflammation and insulin resistance. Prebiotics, probiotics, synbiotics, and postbiotics are often used as supplements to increase the number of beneficial microbes and thus the production of short-chain fatty acids, which have positive effects on the gut microbiome and metabolic syndrome. In this review article, the author summarizes the available supplements to increase the abundance of beneficial gut microbiota and reduce the abundance of harmful microbiota in patients with metabolic disorders. Our group is also researching the role of the gut microbiota in chronic liver disease. This article will be of great help to our research. At the end of the letter, the mechanism of the gut microbiota in chronic liver disease is discussed.

Keywords: Gut microbiome, Metabolic syndrome, Diabetes mellitus, Short-chain fatty acids, Chronic liver disease

Core Tip: I am writing to express my appreciation for the enlightening study titled “Gut microbiome supplementation as therapy for metabolic syndrome” recently published in your esteemed journal. The findings presented in this research shed light on the pivotal role of the gut microbiome in modulating metabolic syndrome, emphasizing the potential therapeutic impact of supplementation. The paper delves into the diverse array of supplements, including probiotics, synbiotics and postbiotics, and their distinct effects on the gut microbiome and its association with metabolic syndrome. I believe that this study will further investigations, inspire clinical trials, and foster the development of targeted interventions to enhance metabolic health through the modulation of the gut microbiome. Our research group is also researching the role of the gut microbiota in chronic liver disease. This article will be of great help to our research.