Systematic Reviews
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2024; 15(3): 552-564
Published online Mar 15, 2024. doi: 10.4239/wjd.v15.i3.552
KCNQ1 rs2237895 gene polymorphism increases susceptibility to type 2 diabetes mellitus in Asian populations
Dong-Xu Li, Li-Ping Yin, Yu-Qi Song, Nan-Nan Shao, Huan Zhu, Chen-Sen He, Jiang-Jie Sun
Dong-Xu Li, Yu-Qi Song, Huan Zhu, First Clinical Medical College, Anhui Medical University, Hefei 230032, Anhui Province, China
Li-Ping Yin, Chen-Sen He, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China
Nan-Nan Shao, School of Clinical Medicine, Anhui Medical University, Hefei 230031, Anhui Province, China
Jiang-Jie Sun, School of Health Care Management, Anhui Medical University, Hefei 230032, Anhui Province, China
Co-first authors: Dong-Xu Li and Li-Ping Yin.
Co-corresponding authors: Chen-Sen He and Jiang-Jie Sun.
Author contributions: Li DX, Yin LP, Sun JJ, and He CS designed this study (substantial contributions to the conception); Li DX, Yin LP, Song YQ, Shao NN, and Zhu H collected data; Li DX and Yin LP extracted and analyzed data, interpretation of data for the work; Sun JJ and He CS provided guidance for statistical analysis and provided financial support. They agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy; Li DX and Yin LP wrote the manuscript; Li DX, Yin LP, Song YQ, Shao NN, Zhu H, Sun JJ and He CS reviewed the manuscript; Li DX and Yin LP contributed equally to this work as co-first authors; Sun JJ and He CS contributed equally to this work as co-corresponding authors. The reasons for designating Li DX and Yin LP as co-first authors are as follows. First, Li DX and Yin LP contributed equal effort throughout the study. The selection of these researchers as co-first authors respects their equal contributions. Second, the research was conducted as a collaborative effort, and the designation of co-first authors accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the research and final paper. The reasons for designating Sun JJ and He CS as co-corresponding authors are as follows. First, Sun JJ and He CS put equal effort into the entire study. Second, the designation of co-corresponding authors best reflects the need for this study to have authors from different fields, which promotes the most in-depth examination of the research topic. In summary, we believe that the designation of Li DX and Yin LP as co-first authors and Sun JJ and He CS as co-corresponding authors meets the requirements of our manuscript, which reflects the spirit of equality and cooperation in our team.
Supported by the Natural Science Foundation for the Higher Education Institutions of Anhui Province of China, No. 2023AH050561, No. 2022AH051143, No. KJ2021A0266, and No. KJ2021A1228; and School-level offline courses, No. 2021xjkc13.
Conflict-of-interest statement: The authors declare no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Jie Sun, PhD, Professor, School of Health Care Management, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui Province, China. sunjiangjie@ahmu.edu.cn
Received: September 25, 2023
Peer-review started: September 25, 2023
First decision: December 6, 2023
Revised: December 13, 2023
Accepted: February 2, 2024
Article in press: February 2, 2024
Published online: March 15, 2024
Abstract
BACKGROUND

The association of single nucleotide polymorphism of KCNQ1 gene rs2237895 with type 2 diabetes mellitus (T2DM) is currently controversial. It is unknown whether this association can be gene realized across different populations.

AIM

To determine the association of KCNQ1 rs2237895 with T2DM and provide reliable evidence for genetic susceptibility to T2DM.

METHODS

We searched PubMed, Embase, Web of Science, Cochrane Library, Medline, Baidu Academic, China National Knowledge Infrastructure, China Biomedical Liter-ature Database, and Wanfang to investigate the association between KCNQ1 gene rs2237895 and the risk of T2DM up to January 12, 2022. Review Manager 5.4 was used to analyze the association of the KCNQ1 gene rs2237895 polymorphism with T2DM and to evaluate the publication bias of the selected literature.

RESULTS

Twelve case–control studies (including 11273 cases and 11654 controls) met our inclusion criteria. In the full population, allelic model [odds ratio (OR): 1.19; 95% confidence interval (95%CI): 1.09–1.29; P < 0.0001], recessive model (OR: 1.20; 95%CI: 1.11–1.29; P < 0.0001), dominant model (OR: 1.27. 95%CI: 1.14–1.42; P < 0.0001), and codominant model (OR: 1.36; 95%CI: 1.15–1.60; P = 0.0003) (OR: 1.22; 95%CI: 1.10–1.36; P = 0.0002) indicated that the KCNQ1 gene rs2237895 polymorphism was significantly correlated with susceptibility to T2DM. In stratified analysis, this association was confirmed in Asian populations: allelic model (OR: 1.25; 95%CI: 1.13–1.37; P < 0.0001), recessive model (OR: 1.29; 95%CI: 1.11–1.49; P = 0.0007), dominant model (OR: 1.35; 95%CI: 1.20–1.52; P < 0.0001), codominant model (OR: 1.49; 95%CI: 1.22–1.81; P < 0.0001) (OR: 1.26; 95%CI: 1.16–1.36; P < 0.0001). In non-Asian populations, this association was not significant: Allelic model (OR: 1.06, 95%CI: 0.98–1.14; P = 0.12), recessive model (OR: 1.04; 95%CI: 0.75–1.42; P = 0.83), dominant model (OR: 1.06; 95%CI: 0.98–1.15; P = 0.15), codominant model (OR: 1.08; 95%CI: 0.82–1.42; P = 0.60. OR: 1.15; 95%CI: 0.95–1.39; P = 0.14).

CONCLUSION

KCNQ1 gene rs2237895 was significantly associated with susceptibility to T2DM in an Asian population. Carriers of the C allele had a higher risk of T2DM. This association was not significant in non-Asian populations.

Keywords: Type 2 diabetes mellitus, KCNQ1, rs2237895, Single nucleotide polymorphism, Asian populations

Core Tip: In Asian populations, the rs2237895 polymorphism in the KCNQ1 gene was significantly associated with susceptibility to type 2 diabetes mellitus (T2DM), and C allele carriers had an increased risk of developing T2DM. The CC and AC genotypes of KCNQ1 rs2237895 significantly increased the susceptibility to T2DM. In non-Asian populations, this association was not significant.