Yi Y, Wang T, Xu W, Zhang SH. Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring. World J Diabetes 2024; 15(3): 378-391 [PMID: 38591094 DOI: 10.4239/wjd.v15.i3.378]
Corresponding Author of This Article
Wei Xu, MD, Professor, Department of Ultrasonography, The First Affiliated Hospital of Yangtze University, No. 55 Jianghan North Road, Shashi District, Jingzhou 434000, Hubei Province, China. jzyycsxw@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Mar 15, 2024; 15(3): 378-391 Published online Mar 15, 2024. doi: 10.4239/wjd.v15.i3.378
Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring
Yan Yi, Tao Wang, Wei Xu, San-Hong Zhang
Yan Yi, Wei Xu, Department of Ultrasonography, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China
Tao Wang, Clinical Molecular Immunology Center, Yangtze University, Jingzhou 434023, Hubei Province, China
San-Hong Zhang, Department of Pediatric, Xiantao First People’s Hospital, Xiantao 433000, Hubei Province, China
Co-first authors: Yan Yi and Tao Wang.
Co-corresponding authors: San-Hong Zhang and Wei Xu.
Author contributions: Yi Y and Wang T reviewed and summarized the literature and wrote the paper; Zhang SH and Xu W designed and revised the manuscript; Xu W is the guarantor of this work; all authors were involved in the critical review of the results and have contributed to read and approved the final manuscript; Yi Y and Wang T contributed equally to this work as co-first authors, Zhang SH and Xu W as co-corresponding authors. The reasons for designating Zhang SH and Xu W as co-correspondent authors are threefold. First, the research was performed as a collaborative effort, and the designation of co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the paper's quality and reliability. Second, the overall research team encompassed authors with a variety of expertise and skills from different fields, and the designation of co-corresponding authors best reflects this diversity. This also promotes the most comprehensive and in-depth examination of the research topic, ultimately enriching readers’ understanding by offering various expert perspectives. Third, Yi Y and Wang T contributed efforts of equal substance throughout the research process. The choice of these researchers as co-first authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Xu, MD, Professor, Department of Ultrasonography, The First Affiliated Hospital of Yangtze University, No. 55 Jianghan North Road, Shashi District, Jingzhou 434000, Hubei Province, China. jzyycsxw@163.com
Received: December 5, 2023 Peer-review started: December 5, 2023 First decision: December 17, 2023 Revised: December 30, 2023 Accepted: February 6, 2024 Article in press: February 6, 2024 Published online: March 15, 2024
Abstract
Gestational diabetes mellitus (GDM) is a pregnancy-related complication characterized by abnormal glucose metabolism in pregnant women and has an important impact on fetal development. As a bridge between the mother and the fetus, the placenta has nutrient transport functions, endocrine functions, etc., and can regulate placental nutrient transport and fetal growth and development according to maternal metabolic status. Only by means of placental transmission can changes in maternal hyperglycemia affect the fetus. There are many reports on the placental pathophysiological changes associated with GDM, the impacts of GDM on the growth and development of offspring, and the prevalence of GDM in offspring after birth. Placental epigenetic changes in GDM are involved in the programming of fetal development and are involved in the pathogenesis of later chronic diseases. This paper summarizes the effects of changes in placental nutrient transport function and hormone secretion levels due to maternal hyperglycemia and hyperinsulinemia on the development of offspring as well as the participation of changes in placental epigenetic modifications due to maternal hyperglycemia in intrauterine fetal programming to promote a comprehensive understanding of the impacts of placental epigenetic modifications on the development of offspring from patients with GDM.
Core Tip: Gestational diabetes mellitus is a pregnancy-related complication characterized by abnormal glucose metabolism in pregnant women and has an important impact on fetal development. The review aims to investigate the effect of abnormal placental function on offspring development in pregnant women with gestational diabetes from the perspective of epigenetics.
