Velikova T, Vasilev G. Insights into glymphatic system dysfunction and glucose continuum. World J Diabetes 2024; 15(12): 2404-2408 [PMID: 39676799 DOI: 10.4239/wjd.v15.i12.2404]
Corresponding Author of This Article
Georgi Vasilev, MD, Clinic of Neurology and Department of Emergency Medicine, UMHAT "Sv. Georgi", Blvd. Peshtersko Shose 66, Plovdiv 4000, Bulgaria. vvasilev.georgi@gmail.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Dec 15, 2024; 15(12): 2404-2408 Published online Dec 15, 2024. doi: 10.4239/wjd.v15.i12.2404
Insights into glymphatic system dysfunction and glucose continuum
Tsvetelina Velikova, Georgi Vasilev
Tsvetelina Velikova, Georgi Vasilev, Medical Faculty, Sofia University St. Kliment Ohridski, Sofia 1407, Bulgaria
Georgi Vasilev, Clinic of Neurology and Department of Emergency Medicine, UMHAT "Sv. Georgi", Plovdiv 4000, Bulgaria
Author contributions: Velikova T and Vasilev G wrote the paper; Velikova T revised the paper. Both authors approved the final version of the manuscript before submission.
Supported by European Union-Next Generation EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria, No. BG-RRP-2.004-0008.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Georgi Vasilev, MD, Clinic of Neurology and Department of Emergency Medicine, UMHAT "Sv. Georgi", Blvd. Peshtersko Shose 66, Plovdiv 4000, Bulgaria. vvasilev.georgi@gmail.com
Received: August 19, 2024 Revised: September 21, 2024 Accepted: October 15, 2024 Published online: December 15, 2024 Processing time: 92 Days and 6.5 Hours
Abstract
In this article, we comment on an original article published in a recent issue of the World Journal of Diabetes. That observational cross-sectional study focused on investigating the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states by using diffusion tensor imaging along the perivascular space (DTI-ALPS) index. It was shown that the cerebral glymphatic system may be dysfunctional in patients with type 2 diabetes. Various clinical variables affected the DTI-ALPS index in different glucose metabolism states. In conclusion, the study by Tian et al improves the understanding of the pathophysiology of diabetes-associated brain damage and provides insights for early diagnosis.
Core Tip: The study underscores the potential dysfunction of the glymphatic system in type 2 diabetes, highlighting its role in diabetic brain damage. Utilizing diffusion tensor imaging along the perivascular space can provide valuable insights into early diagnostic approaches.
