Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2024; 15(11): 2242-2244
Published online Nov 15, 2024. doi: 10.4239/wjd.v15.i11.2242
Atrial fibrillation and prediabetes: Interplay between left atrium and systemic diseases
Ming-Jui Hung
Ming-Jui Hung, Department of Internal Medicine, Section of Cardiovascular Imaging, Division of Cardiology, Chang Gung Memorial Hospital at Keelung, Chang Gung University College of Medicine, Keelung 204201, Taiwan
Author contributions: Hung MJ contributed solely to design, data collection, drafting article and final approval of article.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Jui Hung, MD, PhD, Doctor, Professor, Department of Internal Medicine, Section of Cardiovascular Imaging, Division of Cardiology, Chang Gung Memorial Hospital at Keelung, Chang Gung University College of Medicine, No. 222 Maijin Road, Keelung 204201, Taiwan. miran888@ms61.hinet.net
Received: July 18, 2024
Revised: September 10, 2024
Accepted: September 18, 2024
Published online: November 15, 2024
Processing time: 89 Days and 21.1 Hours
Abstract

Atrial fibrillation (AF) is associated with multiple other comorbidities, i.e. multimorbidity. Prediabetes is one of the multiple comorbidities observed in patients with AF, whereby these two disease entities share the same pathophysiological mechanisms, namely oxidative stress and inflammation. Although prediabetes is reported to have a negative impact on major adverse cardiac or cerebrovascular events in hospitalized AF patients, information about the interactions between prediabetes and AF remains inconsistent. A more in-depth exploration of pathophysiology and more comprehensive prospective clinical studies of AF and diabetes would provide a thorough understanding of the timing of events and further treatment strategies. Deeper investigations are needed to clarify the interactions and causal relationships between AF and prediabetes.

Keywords: Atrial fibrillation; Endothelial dysfunction; Inflammation; Prediabetes; Stroke

Core Tip: Atrial fibrillation (AF) and prediabetes share the same pathophysiological mechanisms, namely oxidative stress and inflammation. Batta et al commented on an article published recently regarding their negative impact on major adverse cardiac or cerebrovascular events in hospitalized AF patients. Further investigations are needed to clarify the interactions and causal relationships between AF and prediabetes.