Zhou X, Guo YL, Xu C, Wang J. Macrophages: Key players in diabetic wound healing. World J Diabetes 2024; 15(11): 2177-2181 [DOI: 10.4239/wjd.v15.i11.2177]
Corresponding Author of This Article
Jun Wang, MD, Chief Doctor, Professor, Department of Ulcers and Peripheral Vascular Surgery, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. tjzywangjun@126.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Nov 15, 2024; 15(11): 2177-2181 Published online Nov 15, 2024. doi: 10.4239/wjd.v15.i11.2177
Macrophages: Key players in diabetic wound healing
Xin Zhou, Yan-Ling Guo, Chuan Xu, Jun Wang
Xin Zhou, Department of Science and Education, Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Huzhou 313000, Zhejiang Province, China
Yan-Ling Guo, Jun Wang, Department of Ulcers and Peripheral Vascular Surgery, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion, Tianjin 300381, China
Chuan Xu, Department of Pharmacy, Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Huzhou 313000, Zhejiang Province, China
Co-corresponding authors: Xin Zhou and Jun Wang.
Author contributions: Zhou X and Wang J conceptualized and designed the editorial, they contributed equally to this editorial and as co-corresponding authors; Guo YL and Xu C contributed to data collection and manuscript editing; Zhou X drafted the manuscript. All authors have reviewed and approved the final version of the manuscript.
Supported byKey Project of the Huzhou City Science and Technology Plan, No. 2023GZ83.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Wang, MD, Chief Doctor, Professor, Department of Ulcers and Peripheral Vascular Surgery, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. tjzywangjun@126.com
Received: July 21, 2024 Revised: September 3, 2024 Accepted: September 18, 2024 Published online: November 15, 2024 Processing time: 86 Days and 22 Hours
Abstract
In this editorial, we discuss the article by Wen et al published. Diabetic foot ulcers are prevalent and serious complications of diabetes, significantly impacting patients’ quality of life and often leading to disability or death, thereby placing a heavy burden on society. Effective diabetic wound healing is hindered by an imbalance in macrophage polarization; many macrophages fail to transition from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, which is crucial for tissue remodelling and repair. The wound healing process is both dynamic and complex. Healthy M1 macrophages, which have strong phagocytic abilities, are vital during the inflammatory phase of diabetic wound healing. However, the failure to transition to M2 macrophages during the proliferative phase hinders wound healing. We anticipate the development of new therapies that can repair damaged M1 macrophages during the inflammatory phase and promote M2 macrophage polarization during the proliferative phase, thereby enhancing the overall healing process.
Core Tip: In this editorial, we discuss the recently published article by Wen et al. Despite significant scientific efforts worldwide, diabetic foot ulcers remain a challenging issue. The authors highlighted the importance of macrophage polarization in diabetic wound healing, and we strongly endorse this perspective. However, we emphasize that future research should also recognize the essential role of healthy M1 macrophages in the diabetic wound healing process.
