Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2023; 14(9): 1412-1421
Published online Sep 15, 2023. doi: 10.4239/wjd.v14.i9.1412
Effect of sitagliptin combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in early diabetic nephropathy
Jun Ling, Yan-Hua Yang
Jun Ling, Yan-Hua Yang, Department of Pharmacy, Changzhou Geriatric Hospital Affiliated to Soochow University, Changzhou NO. 7 People’s Hospital, Changzhou 213000, Jiangsu Province, China
Author contributions: This article was written by Ling J, who independently completed the research design and data analysis; and Yang YH provided important guidance for solving difficult and complex problems.
Institutional review board statement: The study was reviewed and approved by the Biomedical Research Ethics Committee, Changzhou NO. 7 People's Hospital.
Informed consent statement: This is a retrospective study and has applied for exemption from informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data used in this study were obtained from the corresponding author at yyh0728@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Hua Yang, MM, Associate Chief Physician, Department of Pharmacy, Changzhou Geriatric Hospital Affiliated to Soochow University, Changzhou NO. 7 People’s Hospital, No. 288 Yanling East Road, Economic Development Zone, Changzhou 213000, Jiangsu Province, China. yyh0728@163.com
Received: July 4, 2023
Peer-review started: July 4, 2023
First decision: July 19, 2023
Revised: July 27, 2023
Accepted: August 7, 2023
Article in press: August 7, 2023
Published online: September 15, 2023
Processing time: 71 Days and 2.5 Hours
Abstract
BACKGROUND

Early diabetic nephropathy (DN) is a complication of diabetes mellitus. It mainly affects kidney microvessels and glomerular function, and its timely and effective treatment is critical for early DN. However, the effects of treatments comprising simple Western medicine are not optimal. With the promotion and implementation of integrated Chinese and western medicine treatments, remarkable results have been achieved for many diseases. To this end, we explored the clinical efficacy of integrated traditional Chinese and western medicines for the treatment of early DN.

AIM

To investigate the effect of sitagliptin tablets combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in patients with early DN.

METHODS

Through a retrospective analysis, 123 patients with early DN were admitted to the endocrinology clinic of the Changzhou NO. 7 People’s Hospital from January 2021 to October 2022 and were selected as study subjects. After rigorous screening, 100 patients with early DN were enrolled. The control group (CG, n = 50) and the observation group (OG, n = 50) were divided according to the treatment method. The CG were treated with sitagliptin, and the OG were treated with sitagliptin plus the Yiqi yangyin huoxue decoction. Both groups were treated for 3 mo. For both groups, the baseline data and clinical efficacy were compared, and changes in blood glucose levels, lipid levels, renal function, and hematological indicators before (T0) and after (T1) treatment were assessed.

RESULTS

The total effective rate for the OG was 94.00% and that of the CG was 80.00% (P < 0.05). After treatment (T1), the levels of fasting blood glucose, 2 h postprandial glucose, total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol in OG patients were obviously lower than those in the CG (P < 0.05), and cystatin C, homocysteine, urinary microalbumin, and blood creatinine values in OG patients were also obviously lower than those in the CG (P < 0.05); erythrocyte deposition, plasma viscosity, whole blood high shear viscosity, and whole blood low shear viscosity were markedly lower in OG patients than in the CG (P < 0.05).

CONCLUSION

Sitagliptin combined with Yiqi yangyin huoxue decoction has a remarkable effect when used to treat patients with early DN. Further, it is helpful in improving hemorheological indices and controlling disease progression.

Keywords: Sitagliptin; Yiqi yangyin huoxue decoction; Early diabetic nephropathy; Renal function; Clinical effects; Hemorheology

Core Tip: Early diabetic nephropathy (DN) mainly involves kidney microvessels and glomerular functions, and its timely and effective treatment is critical. In clinical practice, the overall treatment effect of medication alone is not ideal. The development of traditional Chinese medicine has demonstrated its superiority for the treatment of many diseases. In the present study, sitagliptin tablets combined with a blood decoction were used to treat patients with early DN. The results showed that sitagliptin combined with Yiqi yangyin huoxue decoction had a significant effect on the treatment of early DN, which was helpful in improving hemorheological indices.