Shrivastav D, Dabla PK, Sharma J, Viswas A, Mir R. Insights on antioxidant therapeutic strategies in type 2 diabetes mellitus: A narrative review of randomized control trials. World J Diabetes 2023; 14(6): 919-929 [PMID: 37383600 DOI: 10.4239/wjd.v14.i6.919]
Corresponding Author of This Article
Pradeep Kumar Dabla, MD, Professor, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, Geeta Colony Road, Delhi 110002, India. pradeep_dabla@yahoo.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dharmsheel Shrivastav, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India
Pradeep Kumar Dabla, Jitender Sharma, Aroop Viswas, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, Delhi 110002, India
Rashid Mir, Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia
Author contributions: Shrivastav D conceptualized the study, retrieved the articles, analyzed the data, tabulated the findings, and drafted and proofread the manuscript; Dabla PK and Sharma J reviewed the data, analyzed the information, guided the inclusion of information, and drafted and proofread the manuscript; Viswas A helped in information retrieval and inclusion of findings; Mir R provided intellectual inputs and proofread the manuscript; Dabla PK conceived & guided the study, provided intellectual inputs, guided the inclusion of information, proofread at all steps, and approved the final version of the manuscript; and all authors contributed to and approved the submitted version.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pradeep Kumar Dabla, MD, Professor, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, Geeta Colony Road, Delhi 110002, India. pradeep_dabla@yahoo.com
Received: December 19, 2022 Peer-review started: December 19, 2022 First decision: January 5, 2023 Revised: January 11, 2023 Accepted: May 11, 2023 Article in press: May 11, 2023 Published online: June 15, 2023
Abstract
BACKGROUND
Type 2 diabetes mellitus (T2DM) is a metabolic disease of impaired glucose utilization. Imbalance in generation and elimination of free radicals generate oxidative stress which modulates glucose metabolism and insulin regulation, resulting in the occurrence and progression of diabetes and associated complications. Antioxidant supplements in T2DM can be seen as a potential preventive and effective therapeutic strategy.
AIM
To compare randomized controlled trials (RCTs) in which antioxidants have been shown to have a therapeutic effect in T2DM patients.
METHODS
We systematically searched the electronic database PubMed by keywords. RCTs evaluating the effect of antioxidant therapy on glycaemic control as well as oxidant and antioxidant status as primary outcomes were included. The outcomes considered were: A reduction in blood glucose; changes in oxidative stress and antioxidant markers. Full-length papers of the shortlisted articles were assessed for the eligibility criteria and 17 RCTs were included.
RESULTS
The administration of fixed-dose antioxidants significantly reduces fasting blood sugar and glycated hemoglobin and is associated with decreased malondialdehyde, advanced oxidation protein products, and increased total antioxidant capacity.
CONCLUSION
Antioxidant supplements can be a beneficial approach for the treatment of T2DM.
Core Tip: Antioxidant supplementation reduces oxidative stress in diabetes. Antioxidant supplementation is a potential therapeutic approach for type 2 diabetes mellitus.
