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World J Diabetes. Dec 15, 2022; 13(12): 1001-1013
Published online Dec 15, 2022. doi: 10.4239/wjd.v13.i12.1001
Non-coding RNAs: Role in diabetic foot and wound healing
Yi-Bo Tang, Muhuza Marie Parfaite Uwimana, Shu-Qi Zhu, Li-Xia Zhang, Qi Wu, Zhao-Xia Liang
Yi-Bo Tang, Muhuza Marie Parfaite Uwimana, Shu-Qi Zhu, Li-Xia Zhang, Qi Wu, Zhao-Xia Liang, Department of Obstetrics, Women’s Hospital School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Tang YB and Uwimana MMP contributed to the design and drafting of the work; Zhu SQ contributed to the acquisition and analysis of data; Zhang LX and Wu Q contributed to the revision of the paper; Liang ZX contributed to the study conception; and all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81974234.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhao-Xia Liang, MD, Professor, Department of Obstetrics, Women’s Hospital School of Medicine, Zhejiang University, No. 1 Xueshi Road, Hangzhou 310006, Zhejiang Province, China. xiaozaizai@zju.edu.cn
Received: August 21, 2022
Peer-review started: August 21, 2022
First decision: October 21, 2022
Revised: October 26, 2022
Accepted: November 18, 2022
Article in press: November 18, 2022
Published online: December 15, 2022
Processing time: 111 Days and 2.1 Hours
Abstract

Diabetic foot ulcer (DFU) and poor wound healing are chronic complications in patients with diabetes. The increasing incidence of DFU has resulted in huge pressure worldwide. Diagnosing and treating this condition are therefore of great importance to control morbidity and improve prognosis. Finding new markers with potential diagnostic and therapeutic utility in DFU has gathered increasing interest. Wound healing is a process divided into three stages: Inflammation, proliferation, and regeneration. Non-coding RNAs (ncRNAs), which are small protected molecules transcribed from the genome without protein translation function, have emerged as important regulators of diabetes complications. The deregulation of ncRNAs may be linked to accelerated DFU development and delayed wound healing. Moreover, ncRNAs can be used for therapeutic purposes in diabetic wound healing. Herein, we summarize the role of microRNAs, long ncRNAs, and circular RNAs in diverse stages of DFU wound healing and their potential use as novel therapeutic targets.

Keywords: Diabetic foot ulcer; Wound healing; MicroRNA; Long non-coding RNAs; Circular RNAs; Inflammation; Proliferation; Regeneration

Core Tip: Non-coding RNAs (ncRNAs) have emerged as important regulators of diabetic foot and wound healing. NcRNAs can be used for therapeutic purposes in diabetic wound healing. In this study, we summarize the roles of microRNAs, long ncRNAs, and circular RNAs in diverse stages of diabetic foot ulcer wound healing and their potential use as novel therapeutic targets.