Published online Apr 15, 2020. doi: 10.4239/wjd.v11.i4.95
Peer-review started: December 23, 2019
First decision: January 29, 2020
Revised: February 19, 2020
Accepted: February 23, 2020
Article in press: February 23, 2020
Published online: April 15, 2020
Processing time: 105 Days and 1.5 Hours
Diabetes mellitus continues to present a large social, financial and health system burden across the world. The relationship between age of onset of the different types of diabetes and all-cause mortality is uncertain. In this review paper, the relationship between age of onset of the different types of diabetes and all-cause mortality will be reviewed and an update of the current evidence will be presented. There is strong evidence of the relationship between age of onset of type 2 diabetes mellitus (T2DM) and all-cause mortality, good evidence of the relationship between age of onset of T1DM and all-cause mortality and no evidence of the relationship between age of onset of gestational diabetes or prediabetes and all-cause mortality. Further research is needed to look at whether aggressive management of earlier onset of T2DM can help to reduce premature mortality.
Core tip: In this review paper we will look at the relationship between age of onset of the different types of diabetes (type 1 diabetes mellitus, type 2 diabetes mellitus, gestational and prediabetes) and all-cause mortality and provides an update of the current evidence.