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World J Diabetes. Dec 15, 2020; 11(12): 567-571
Published online Dec 15, 2020. doi: 10.4239/wjd.v11.i12.567
Identification of miR-802-5p and its involvement in type 2 diabetes mellitus
Kaushik Vishnu Rajkumar, Ganesh Lakshmanan, Durairaj Sekar
Kaushik Vishnu Rajkumar, Ganesh Lakshmanan, Department of Anatomy, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai 600077, India
Durairaj Sekar, Dental Research Cell and Biomedical Research Unit (DRC-BRULAC), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai 600077, India
Author contributions: Rajkumar KV completed the experimental work and execution; Lakshmanan G finished manuscript corrections and results analysis; and Sekar D completed manuscript writing, experimental work and data analysis.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Durairaj Sekar, PhD, Professor, Dental Research Cell and Biomedical Research Unit (DRC-BRULAC), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, 162, Poonamallee High Rd, Velappanchavadi, Chennai 600077, India. duraimku@gmail.com
Received: June 26, 2020
Peer-review started: June 26, 2020
First decision: September 24, 2020
Revised: October 3, 2020
Accepted: October 29, 2020
Article in press: October 29, 2020
Published online: December 15, 2020
Processing time: 169 Days and 20.4 Hours
Abstract

MicroRNAs (miRNA) are recently discovered endogenous, small noncoding RNAs (of 22 nucleotides) that play pivotal roles in gene regulation. They are involved in post-transcriptional control of gene expression. miRNAs are emerging as important regulators of cell proliferation, development, cancer formation, stress responses, cell death and physiological conditions. Increasing evidence has demonstrated the human miRNAs bind to their target mRNA sequences with perfect or near-perfect sequence complementarily. This provides a powerful strategy for discovering potential type 2 diabetes mellitus (T2DM) targets and gives the probability to exploit them for diagnostic and therapeutic causes. About 6% of the world population is affected by T2DM, and it is recognized as a global epidemic by the World Health Organization. At present there is no valid biomarker to control or manage T2DM. Therefore, the present study applied a mature sequence of miRNAs from publicly accessible databases to identify the miRNA from T2DM expressed sequence tags, and the results are detailed and discussed below.

Keywords: MicroRNAs; Type 2 diabetes mellitus; miR-802-5p; Biomarker; Expressed sequence tags; Disease

Core Tip: MicroRNAs (miRNA) are endogenous, small noncoding RNAs that play pivotal roles in gene regulation. They are involved in post-transcriptional control of gene expression and are important regulators of cell proliferation, development, cancer formation, stress responses, cell death and physiological conditions. About 6% of the world population is affected by type 2 diabetes mellitus. It is recognized as a global epidemic. At present there is no valid biomarker to control or manage type 2 diabetes mellitus. The present study applied a mature sequence of miRNAs from publicly accessible databases to identify miRNAs from type 2 diabetes mellitus expressed sequence tags.