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Domínguez R, López-León I, Moreno-Lara J, Rico E, Sánchez-Oliver AJ, Sánchez-Gómez Á, Pecci J. Sport supplementation in competitive swimmers: a systematic review with meta-analysis. J Int Soc Sports Nutr 2025; 22:2486988. [PMID: 40205676 PMCID: PMC11986859 DOI: 10.1080/15502783.2025.2486988] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2024] [Accepted: 03/09/2025] [Indexed: 04/11/2025] Open
Abstract
BACKGROUND Competitive swimmers have a high prevalence of sports supplement (SS) consumption. However, only a few SS are scientifically proven to be safe, effective, and legal. Therefore, before incorporating supplements to enhance performance and health in competitive swimming, it is crucial to conduct an analysis and review to assess their effects. The objective of this study was to analyze the demonstrated effects of SS, as reported in published studies, on the swimming performance of competitive swimmers. METHODS Following PRISMA guidelines, a systematic search was conducted across six databases for the selection of studies included in this review. Studies that analyzed the effects of sports supplementation compared to placebo were included and subjected to meta-analysis. RESULTS This revision included 23 studies, 16 of them (69.6%) qualified as excellent and 7 (30.4%) as good at the methodological level based on the punctuation in the PEDro scale. The systematic review included 422 swimmers (61.8% male, 38.2% female), with distances assessed ranging from 50 m to 800 m, including studies employing interval procedures. Creatine showed a significant effect (ES = -0.46; 95% CIs = -0.75 to -0.17, p = 0.002; I2 = 11%) on swimming performance, while the rest of the analyzed supplements did not show significant effects (all p > 0.05). CONCLUSIONS Creatine supplementation demonstrated ergogenic benefits for competitive swimmers, although the evidence supporting the use of this supplement is still limited. Sodium bicarbonate and β-alanine may enhance performance in distances with higher glycolytic demands, while caffeine is effective at dosages of 3-6 mg/kg administered 60 min before exercise. Further research is needed to confirm the potential ergogenic effects of other supplements, such as beetroot juice.
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Affiliation(s)
- Raúl Domínguez
- Universidad de Sevilla, Departamento de Motricidad Humana Rendimiento Deportivo, Sevilla, Spain
- University of Lavras, Studies Research Group in Neuromuscular Responses (GEPREN), Lavras, Brazil
| | - Inmaculada López-León
- Universidad de Sevilla, Departamento de Motricidad Humana Rendimiento Deportivo, Sevilla, Spain
| | - Javier Moreno-Lara
- Universidad de Sevilla, Departamento de Motricidad Humana Rendimiento Deportivo, Sevilla, Spain
| | - Esteban Rico
- Universidad de Sevilla, Departamento de Motricidad Humana Rendimiento Deportivo, Sevilla, Spain
| | - Antonio J. Sánchez-Oliver
- Universidad de Sevilla, Departamento de Motricidad Humana Rendimiento Deportivo, Sevilla, Spain
- University of Lavras, Studies Research Group in Neuromuscular Responses (GEPREN), Lavras, Brazil
| | - Ángela Sánchez-Gómez
- Universidad de Córdoba, Departamento de Enfermería Farmacología y Fisioterapia, Facultad de Medicina y Enfermería, Córdoba, España
| | - Javier Pecci
- University of Seville, Department of Physical Education and Sport, Seville, Spain
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Cheungpasitporn W, Wathanavasin W, Thongprayoon C, Kaewput W, Tapolyai M, Fülöp T. Critical appraisal of systematic reviews and meta-analyses: a step-by-step guide for nephrologists. Ren Fail 2025; 47:2476736. [PMID: 40143401 PMCID: PMC11951313 DOI: 10.1080/0886022x.2025.2476736] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/14/2024] [Revised: 02/20/2025] [Accepted: 02/28/2025] [Indexed: 03/28/2025] Open
Abstract
BACKGROUND Systematic reviews and meta-analyses play a pivotal role in evidence-based medicine, including nephrology, by consolidating findings from multiple studies. To maximize their utility, rigorous quality assessment during peer review is essential. Challenges such as heterogeneity, bias, and methodological flaws often undermine these studies, necessitating a structured appraisal process. METHODS This guide outlines a framework for nephrologists on appraising systematic reviews and meta-analyses. Key areas include heterogeneity assessment using the I2 statistic, interpretation of forest plots for pooled effect estimates, and the use of funnel plots with Egger's test to identify potential publication bias. Risk of bias is evaluated using RoB 2 for randomized controlled trials and ROBINS-I for non-randomized studies. Subgroup and sensitivity analyses, along with meta-regression, address heterogeneity and examine the robustness of findings. RESULTS The I2 statistic quantifies heterogeneity by estimating the proportion of variability in a meta-analysis. Funnel plots and Egger's test help detect publication bias. Major biases, such as selection, performance, detection, and publication bias, are identified using structured tools like AMSTAR 2, Cochrane RoB 2, and ROBINS-I. The GRADE framework further assesses the overall certainty of the evidence. Emphasis is placed on PRISMA compliance, protocol pre-registration, and transparent reporting of statistical analyses, subgroup, and sensitivity assessments. The inclusion of grey literature remains optional. CONCLUSION By focusing on key areas such as heterogeneity, risk of bias, and robust statistical methods, this guide enables nephrologists to critically appraise systematic reviews and meta-analyses, fostering better clinical decision-making and improved patient care in nephrology.
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Affiliation(s)
| | - Wannasit Wathanavasin
- Division of Nephrology, Department of Medicine, Mayo Clinic, Rochester, MN, USA
- Nephrology Unit, Department of Medicine, Charoenkrung Pracharak Hospital, Bangkok Metropolitan Administration, Bangkok, Thailand
| | - Charat Thongprayoon
- Division of Nephrology, Department of Medicine, Mayo Clinic, Rochester, MN, USA
| | - Wisit Kaewput
- Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand
| | - Mihály Tapolyai
- Department of Nephrology, Szent Margit Kórház, Budapest, Hungary
- Medicine Service, Ralph H. Johnson VA Medical Center, Charleston, SC, USA
| | - Tibor Fülöp
- Medicine Service, Ralph H. Johnson VA Medical Center, Charleston, SC, USA
- Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
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Nolting IKL, Morina N, Hoppen TH, Tam KP, Kip A. A meta-analysis on gender differences in prevalence estimates of mental disorders following exposure to natural hazards. Eur J Psychotraumatol 2025; 16:2476809. [PMID: 40135376 PMCID: PMC11948360 DOI: 10.1080/20008066.2025.2476809] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/25/2024] [Revised: 01/12/2025] [Accepted: 02/18/2025] [Indexed: 03/27/2025] Open
Abstract
Background: Women report higher rates of trauma-related disorders compared to men. With women being disproportionately impacted by the consequences of natural hazards, this gender disparity may increase in their aftermath.Objective: This meta-analysis aimed at quantifying gender gaps in mental disorder prevalence following natural hazards, considering both the recent and long-term aftermath of natural hazards, the developmental status of affected countries, and type of hazard.Method: A systematic search was conducted in MEDLINE, PsycINFO, and Web of Science in February 2024. Random effects models were used to calculate odds ratios (OR) based on point prevalences. OR adjusted for covariates were also descriptively reported.Results: In total, 141 reports (N = 3,726,153 independent participants) were included. The prevalence for posttraumatic stress disorder (PTSD), major depression (MD), and generalized anxiety disorder (GAD) within the first year after the hazard were 24.95%, 8.11%, and 14.24%, respectively. More than one-year post-natural hazard the prevalence for PTSD and MD were 22.89% and 13.51%, respectively. Women had significantly higher odds for PTSD (OR = 1.85) and MD (OR = 1.52) within the first year after the hazard, as well as in later assessments (OR = 1.83 for PTSD, OR = 1.41 for MD). Only four studies reported on GAD gender differences in the recent aftermath of natural hazards, resulting in a non-significant OR of 1.85. Subgroup analyses indicated no differences between developmental status of affected countries and adjusted OR showed no systematic variations upon the inclusion of covariates. Gender differences were larger in the aftermath of earthquakes.Conclusions: Significant gender differences for mental disorders following natural hazards exist, although these differences appear similar to other contexts. Gender-sensitive disaster response plans for mental health are essential.
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Affiliation(s)
| | - Nexhmedin Morina
- Institute of Psychology, University of Münster, Münster, Germany
- Department of Psychology, New School for Social Research, New York, NY, USA
| | | | - Kim-Pong Tam
- Division of Social Science, The Hong Kong University of Science and Technology, Hong Kong, China
| | - Ahlke Kip
- Institute of Psychology, University of Münster, Münster, Germany
- Medical Psychology and Medical Sociology, Faculty of Medicine, University of Freiburg, Freiburg, Germany
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Wang HF, Liu S, Cao Y, Li QS. Bidirectional association between atopic dermatitis and attention deficit hyperactivity disorder: a systematic review and meta-analysis. Ann Med 2025; 57:2483370. [PMID: 40159827 PMCID: PMC11960313 DOI: 10.1080/07853890.2025.2483370] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/13/2024] [Revised: 01/22/2025] [Accepted: 03/12/2025] [Indexed: 04/02/2025] Open
Abstract
BACKGROUND Our objective is to elucidate the reciprocal association between atopic dermatitis (AD) and attention deficit hyperactivity disorder (ADHD) by prespecified subgroups and determine potential modified factors. MATERIALS AND METHODS Adhering to PRISMA 2020, we conducted a comprehensive database search up until March 11, 2024. Observational studies reporting on AD and ADHD as either exposure or outcome variables were included. A random-effects model meta-analysis was conducted to calculate pooled estimates. Subgroup and meta-regression analyses were undertaken to explore heterogeneity. Publication bias was investigated via funnel plots and Egger's test. RESULTS Overall, 49 studies were determined to meet the inclusion criteria after rigorous screening. Patients with AD were more likely to have ADHD (ORs = 1.34, 95% CI 1.25-1.44, p < 0.01; HRs = 1.42, 95% CI 1.20-1.68, p < 0.01), while patients with ADHD also had an increased risk of developing AD (ORs = 1.45, 95% CI 1.21-1.73, p < 0.01). Subgroup analyses indicated that the associations were particularly pronounced among studies that assessed patients with severe AD (ORs = 2.62, 95% CI 1.76-3.92, p < 0.01), suffered from multiple allergic conditions (ORs = 2.89, 95% CI 1.18-7.10, p < 0.01) and sleep disturbances (ORs = 2.43, 95% CI 2.14-2.76, p < 0.01) simultaneously. CONCLUSION This review substantiates the significant bidirectional association between AD and ADHD, indicating that they serve as mutually independent risk factors and may either exacerbate each other. These findings underscore the necessity for heightened awareness and early targeted interventions, especially in individuals with severe AD manifestations, sleep problems, and multiple allergic diseases.
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Affiliation(s)
- Hong-Fei Wang
- First School of Clinical Medicine, Zhejiang Chinese Medicine University, Hangzhou, China
| | - Shan Liu
- Center of Clinical Evaluation and Analysis, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China
| | - Yi Cao
- The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China
| | - Qiu-Shuang Li
- Center of Clinical Evaluation and Analysis, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China
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Jiang S, Liu S, Xiao G, Liu K, Li J. Atherogenic index of plasma and the clinical outcome of patients with acute coronary syndrome: a meta-analysis. Ann Med 2025; 57:2442532. [PMID: 39727274 DOI: 10.1080/07853890.2024.2442532] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/13/2024] [Revised: 05/17/2024] [Accepted: 05/22/2024] [Indexed: 12/28/2024] Open
Abstract
BACKGROUND The atherogenic index of plasma (AIP) has been related to an increased risk of coronary artery disease. However, previous studies evaluating the prognostic role of AIP for acute coronary syndrome (ACS) showed inconsistent results. This meta-analysis was conducted to systematically evaluate the association between AIP and the risk of major cardiovascular adverse events (MACE) of patients with ACS. MATERIALS AND METHODS Relevant cohort studies were retrieved by searching electronic databases, including PubMed, Web of Science, and Embase. A random-effects model was used to combine the data by incorporating the influence of between-study heterogeneity. RESULTS Thirteen datasets from nine cohort studies, involving 10,861 patients with ACS were included in the meta-analysis. Of them, 1546 (14.2%) developed MACE during follow-up. Pooled results suggested that a high AIP at admission was associated with an increased risk of MACE during follow-up (risk ratio [RR]: 1.54, 95% confidence interval [CI]: 1.30-1.82, p < 0.001; I2 = 48%). Subgroup analyses suggested a stronger association between a high AIP and an increased risk of MACE in older patients (mean age ≥60 years, RR: 2.26, 95% CI: 1.78-2.87, p < 0.001; I2 = 0%) than the younger ones (mean age <60 years, RR: 1.30, 95% CI: 1.17-1.44, p < 0.001; I2 = 0%; p for subgroup difference <0.001), which fully explained the heterogeneity. CONCLUSION A high AIP is associated with an increased risk of MACE in patients with ACS, particularly for older patients.
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Affiliation(s)
- Sihai Jiang
- Department of Emergency, Shaoyang Central Hospital, Shaoyang, China
| | - Suying Liu
- Department of Cardiovascular Medicine, The Second Affiliated Hospital of Shaoyang University, Shaoyang, China
| | - Guie Xiao
- Department of Emergency, Shaoyang Central Hospital, Shaoyang, China
| | - Kexuan Liu
- Department of Emergency, Shaoyang Central Hospital, Shaoyang, China
| | - Jialin Li
- Department of Emergency, Shaoyang Central Hospital, Shaoyang, China
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Wang D, Pang X, Shen P, Mao D, Song Q. Effectiveness of various exercise types in reducing fall risk among older adults with diabetic peripheral neuropathy: A systematic review and meta-analysis. J Exerc Sci Fit 2025; 23:157-166. [PMID: 40242133 PMCID: PMC12002931 DOI: 10.1016/j.jesf.2025.03.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/29/2024] [Revised: 03/25/2025] [Accepted: 03/31/2025] [Indexed: 04/18/2025] Open
Abstract
Background Diabetic peripheral neuropathy (DPN) increases fall risk in diabetics. Due to varying variables used to assess fall risk, the impact of exercise on fall prevention remains inconsistent. This study reviews and compares the effects of different exercises on fall risk among older adults with DPN. Methods A comprehensive literature search was conducted in PubMed, EBSCO, Web of Science, and Cochrane Library up to February 17th, 2025. Inclusion criteria were: older adults with DPN; exercise intervention only, an inactive or non-exercising control group, and randomized controlled trials with outcome variables: timed up and go (TUG) time, gait speed, Berg Balance Scale (BBS) score, one-legged standing (OLS) time with eye open (EO) and closed (EC). The mean difference (MD) and 95 % confidence interval (CI) were calculated. Results A total of 21 articles included five exercise types: balance exercise (BE), multi-component exercise (ME), strength exercise (SE), whole-body vibration (WBV) and foot-ankle functional training (FT). BE reduced TUG time (MD = -1.47, 95 % CI = -1.79 to -1.15) and increased gait speed (0.11, 0.04-0.18), BBS score (0.93, 0.49-1.37), and OLS time (EO: 2.72, 1.86-3.58; EC:1.58, 1.0-2.17). ME reduced TUG time (-1.71, -2.26 to -1.17) and increased BBS score (2.0, 1.28-2.72) and OLS time (EO: 7.07, 4.35-9.79; EC: 2.61, 1.28-3.94); SE reduced TUG time (-1.45, -2.75 to -0.15) and increased gait speed (0.09, 0.06-0.12); WBV increased OLS time (EO: 1.94, 1.32-2.56; EC: 1.86, 0.16-3.56) but did not affect TUG time or gait speed. FT did not affect TUG time or gait speed. Conclusions Exercise reduced fall risks among older adults with DPN. BE and ME were effective in reducing fall risks, followed by SE. WBV improved static balance but failed in dynamic balance. FT showed limited effects on fall prevention and was not recommended.
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Affiliation(s)
- Dongmei Wang
- College of Sports and Health, Shandong Sport University, Jinan, 250102, China
- Biomechanics Laboratory College of Human Movement Science, Beijing Sport University, Beijing, 100084, China
| | - Xiangsheng Pang
- Department of Physical Education, College of Education, Zhejiang University, Hangzhou, Zhejiang, 310058, China
| | - Peixin Shen
- College of Sports and Health, Shandong Sport University, Jinan, 250102, China
| | - Dewei Mao
- School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, 518172, China
| | - Qipeng Song
- College of Sports and Health, Shandong Sport University, Jinan, 250102, China
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Huh MD, Le SN, O'Brien KS, Keenan JD, Stewart JM. Potential Efficacy of Metformin for Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis. OPHTHALMOLOGY SCIENCE 2025; 5:100741. [PMID: 40230880 PMCID: PMC11994399 DOI: 10.1016/j.xops.2025.100741] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 01/06/2025] [Revised: 02/02/2025] [Accepted: 02/10/2025] [Indexed: 04/16/2025]
Abstract
Topic Metformin, a widely used diabetes medication, has shown potential for treating age-related macular degeneration (AMD) due to its antioxidative, anti-inflammatory, and antiangiogenic properties. This study aims to systematically review and analyze the efficacy of metformin in reducing AMD prevalence. Clinical Relevance Metformin's potential to serve as a treatment for AMD could significantly reduce the burden of vision loss, offering a cost-effective and widely accessible solution. Methods A systematic search was conducted in OVID Embase, OVID MEDLINE, Cochrane Library, and Web of Science databases on May 2, 2024. Both observational and interventional studies were included if they involved oral metformin use before AMD diagnosis. Data were extracted and analyzed using a random-effects model meta-analysis, with subgroup analyses based on study design, AMD subtype, sex, and metformin dosage. Results Eighteen observational studies were identified, which together included a total of 2 683 234 individuals. Nine studies had a case-control design, 7 were retrospective cohort studies, and 2 were cross-sectional studies. The meta-analysis revealed a significant reduction in the odds of AMD among metformin users (pooled odds ratio [OR] = 0.86, 95% confidence interval = 0.79-0.93, P = 0.0002, I2 = 90%). The association was significant in both patients with diabetes (pooled OR = 0.89) and without diabetes (pooled OR = 0.70), although only 2 studies reported nondiabetic ORs. Dose-response analysis revealed significant protective effects at low doses. Sensitivity analysis indicated that the removal of an outlier study did not alter the overall effect. Bias analysis using the Risk of Bias in Nonrandomized Studies of Interventions tool revealed significant risks of bias, particularly due to confounding. Conclusion Although the current evidence suggests a potential protective role of metformin in AMD, all studies showing an effect of metformin have been observational and thus subject to bias. Randomized clinical trials are needed to determine the effectiveness of metformin for preventing the onset of AMD. Financial Disclosures Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Affiliation(s)
- Matthew D. Huh
- Department of Ophthalmology, University of California, San Francisco, San Francisco, California
- Department of Ophthalmology, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California
| | - Simon N. Le
- Department of Ophthalmology, University of California, San Francisco, San Francisco, California
| | - Kieran S. O'Brien
- Department of Ophthalmology, University of California, San Francisco, San Francisco, California
- Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, San Francisco, California
| | - Jeremy D. Keenan
- Department of Ophthalmology, University of California, San Francisco, San Francisco, California
- Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, San Francisco, California
| | - Jay M. Stewart
- Department of Ophthalmology, University of California, San Francisco, San Francisco, California
- Department of Ophthalmology, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California
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Zhang J, Yuan M, Liu Y, Zhong X, Wu J, Chen W. Bisphenol A exposure and neurodevelopmental disorders and problems in children under 12 years of age: A systematic review and meta-analysis. JOURNAL OF HAZARDOUS MATERIALS 2025; 490:137731. [PMID: 40054188 DOI: 10.1016/j.jhazmat.2025.137731] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/24/2024] [Revised: 02/12/2025] [Accepted: 02/22/2025] [Indexed: 04/16/2025]
Abstract
BACKGROUND Bisphenol A (BPA) exposure may lead to neurodevelopmental disorders and problems (NDPs) in children under 12 years old. In recent years, the number of relevant studies has increased, but the evidence is inconsistent. Therefore, we conducted a comprehensive systematic review and meta-analysis to determine the association between BPA exposure and NDPs and potential gender differences. METHODS A literature search was conducted in eight bibliographic databases for peer-reviewed research articles published from database inception to October 11, 2024. Eligible studies were epidemiological, observational studies in children under 12 years old, which evaluated the associations between BPA of biosamples and NDPs. The converted effect sizes were synthesized using multilevel random effects meta-analysis models. Meta-regression analysis, sensitivity analysis, unmeasured confounding bias, and publication bias tests were examined to substantiate the results. RESULTS The search identified 1090 unique studies, 32 of which involving 15,669 participants were finally included in the meta-analysis. The meta-analysis showed that BPA exposure was associated with intellectual disability (Cohen's d = 0.14, 95 %CI = 0.06-0.22), autism spectrum disorder (ASD, Cohen's d = 0.10, 95 %CI = 0.02-0.17), attention deficit and hyperactivity disorder (ADHD, Cohen's d = 0.28, 95 %CI = 0.10-0.47), and communication disorders (Cohen's d = 0.12, 95 %CI = 0.01-0.23) in all children. Gender differences exist while BPA was associated with intellectual disability, ASD, ADHD, and motor disorders in boys, and with intellectual disability and ADHD in girls. CONCLUSION This study indicated that BPA exposure was associated with an increased risk of NDPs in children, particularly in boys, underscoring the importance of considering BPA exposure as a potential risk factor for children's brain health.
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Affiliation(s)
- Jianghui Zhang
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China; Center for Migrant Health Policy, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China
| | - Minglu Yuan
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China; Center for Migrant Health Policy, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China
| | - Ying Liu
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China; Department of Children's Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 511400, China
| | - Xinyuan Zhong
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China; Center for Migrant Health Policy, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China
| | - Jieling Wu
- Department of Children's Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 511400, China
| | - Wen Chen
- Department of Medical Statistics, School of Public Health, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China; Center for Migrant Health Policy, Sun Yat-sen University, #74 Zhongshan Road 2, Guangzhou 510080, China.
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Ganse-Dumrath A, Chohan A, Samuel S, Bretherton P, Haenschel C, Fett AK. Systematic review and meta-analysis of early visual processing, social cognition, and functional outcomes in schizophrenia spectrum disorders. Schizophr Res Cogn 2025; 40:100351. [PMID: 40028174 PMCID: PMC11872129 DOI: 10.1016/j.scog.2025.100351] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2024] [Revised: 02/07/2025] [Accepted: 02/07/2025] [Indexed: 03/05/2025]
Abstract
Non-affective psychotic disorders are marked by cognitive and sensory processing abnormalities, including in early visual processing and social cognition. Understanding the relationships between these deficits and their impact on daily-life functional outcomes may help to improve outcomes in affected individuals. This systematic review and meta-analysis aimed to summarise the existing evidence on the relationships between early visual processing, social cognition, and functional outcomes, and to assess the evidence regarding the mediating role of social cognition in the association between early visual processing and functional outcomes in individuals with schizophrenia spectrum disorders. A comprehensive search across five databases identified 364 potentially eligible studies, with eight articles meeting all inclusion criteria. Meta-analytic techniques were employed to synthesise effect sizes and assess a meta-mediation model. Three random-effects meta-analyses revealed significant associations between all three domains of interest. Social cognition partially mediated the relationship between early visual processing and functional outcomes. The direct effect of early visual processing on functional outcomes remained significant, albeit with a reduced effect size. The findings suggest that interventions targeting both early visual processing and social cognition concurrently may improve functional outcomes more effectively than focusing on either domain alone.
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Affiliation(s)
- Akke Ganse-Dumrath
- Department of Psychology, School of Health and Medical Sciences, City St George's, University of London, UK
| | - Anya Chohan
- Department of Psychology, School of Health and Medical Sciences, City St George's, University of London, UK
| | - Steven Samuel
- Department of Psychology, School of Health and Medical Sciences, City St George's, University of London, UK
| | - Paul Bretherton
- Department of Psychology, School of Health and Medical Sciences, City St George's, University of London, UK
| | - Corinna Haenschel
- Department of Psychology, School of Health and Medical Sciences, City St George's, University of London, UK
| | - Anne-Kathrin Fett
- Department of Psychology, School of Health and Medical Sciences, City St George's, University of London, UK
- Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK
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Fernández-Fernández R, Ibias J, Del Toro-Pérez C, Lahera G, Gasca-Salas C. Alexithymia in Parkinson's Disease: A Meta-analysis. Am J Geriatr Psychiatry 2025; 33:638-653. [PMID: 39732593 DOI: 10.1016/j.jagp.2024.11.009] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/21/2024] [Revised: 10/26/2024] [Accepted: 11/04/2024] [Indexed: 12/30/2024]
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor manifestations, including alexithymia. This condition is defined by difficulty in recognizing, articulating, and expressing one's emotional states. In this study, we conducted a systematic review and meta-analysis to compare the prevalence of alexithymia in PD patients and a healthy population, and to identify associated demographic and clinical factors. We identified 16 observational studies through Pubmed, EMBASE, PsycINFO, and SCOPUS, selecting articles published since 2002. Data were analyzed using a random-effects model. We conducted additional prevalence meta-analyses and correlation meta-analyses. We found that PD patients exhibit higher levels of alexithymia compared to the general population (combined effect size 0.65 [95% CI = 0.49-0.81; P <0.05]), and moderate but significant heterogeneity (I² = 52.42%, Q = 29.42, P <0.05), partially explained by regional differences, levodopa equivalent dosage (positive regression coefficient of 0.0006 [95% CI = 0.0001; 0.0011, P <0.05]); and cognitive scores (negative regression coefficient of -0.14 [95% CI = -0.24; -0.04, P<0.05]), after adjusting for covariates. The additional meta-analysis reported higher prevalence of alexithymia in PD and a pooled correlation coefficient of 0.496 (95% CI = 0.40-0.59, P <0.05) when we analyzed alexithymia and depression scores. To our knowledge, there are no previous meta-analysis applied to alexithymia in PD patients. Even though we could not determine whether alexithymia is a primary characteristic of PD, we found an association of higher levels of alexithymia with depression and higher levodopa equivalent daily dose. Furthermore, there are not enough studies to draw clear conclusions about the influence of cognitive status.
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Affiliation(s)
- Roberto Fernández-Fernández
- HM CINAC (Centro Integral de Neurociencias Abarca Campal) (RFF, CDTP, CGS), Hospital Universitario HM Puerta del Sur, HM Hospitales. Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales (RFF, CDTP, CGS), Madrid, Spain; Hospital Universitario Infanta Cristina (RFF), Madrid. Spain; PhD Program in Health Sciences (RFF), University of Alcalá de Henares, Madrid, Spain
| | - Javier Ibias
- Department of Behavioral Sciences and Methodology (JI), Faculty of Psychology, National Distance Education University (UNED), Madrid, Spain
| | - Cristina Del Toro-Pérez
- HM CINAC (Centro Integral de Neurociencias Abarca Campal) (RFF, CDTP, CGS), Hospital Universitario HM Puerta del Sur, HM Hospitales. Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales (RFF, CDTP, CGS), Madrid, Spain
| | - Guillermo Lahera
- Department of Medicine and Medical Specialities (GL), University of Alcala, Alcalá de Henares, Spain; Ramón y Cajal Institute of Sanitary Research (IRYCIS) (GL), Madrid, Spain; Psychiatry Service (GL, CGS), Center for Biomedical Research in the Mental Health Network, University Hospital Príncipe de Asturias, Alcalá de Henares, Spain
| | - Carmen Gasca-Salas
- HM CINAC (Centro Integral de Neurociencias Abarca Campal) (RFF, CDTP, CGS), Hospital Universitario HM Puerta del Sur, HM Hospitales. Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales (RFF, CDTP, CGS), Madrid, Spain; Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) (CGS), Instituto Carlos III, Madrid, Spain; University CEU-San Pablo (CGS), Madrid, Spain.
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Lu VYZ, Shah H, Alshaber Z, Limonard A, Domos P. Non-operative versus reverse shoulder arthroplasty for the treatment of 3- or 4-part proximal humeral fractures: A systematic review and meta-analysis. J Clin Orthop Trauma 2025; 65:102982. [PMID: 40224508 PMCID: PMC11986627 DOI: 10.1016/j.jcot.2025.102982] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/09/2024] [Revised: 02/14/2025] [Accepted: 03/20/2025] [Indexed: 04/15/2025] Open
Abstract
Background Proximal humerus fractures (PHFs) are a common injury experienced by elderly patients, however there is no consensus regarding the best treatment option. Recently, the use of reverse shoulder arthroplasty (RSA) in elderly patients with complex fractures is increasing. This systematic review and meta-analysis will compare the outcomes between RSA and non-operative treatment in 3- or 4-part PHFs in the elderly. Methods This study was conducted according to the PRISMA statement protocol and registered in PROSPERO (CRD42023439647). Searches on four databases (Medline, Embase, Web of Science, and Cochrane Library) were performed, and comparative studies which compared the outcomes of using RSA with conservative management were included. Demographic data, patient related outcome measures (PROMs), and complications rates were collected. Data were pooled using a random-effects model. Heterogeneity was determined using the I2 statistic and Cochran's Q test. Results Six studies involving 439 patients (mean age 79.0 years old; 12.1 % male) were analysed. The average Charlson co-morbidity index (CCI) was 3.74 and follow-up time was 26.0 months. Compared to the non-operative cohort, the RSA cohort had better VAS scores (1.0 versus 0.575; p = 0.047), Constant-Murley scores (66.3 versus 71; p = 0.114), active forward flexion (121.5° versus 100°; p = 0.023; I2 = 35 %), external rotation (34.8° vs 23.1°; p = 0.020), and internal rotation (Constant score 5.44 versus 4.28; p = 0.169). There is no difference in the overall risk of complications (8.2 % versus 6.0 %; RR = 1.00; p = 0.993), but those treated by RSA have a higher risk of needing subsequent revision surgery (3.7 % versus 2.8 %; p = 0.640; I2 = 25 %). Conclusion In the short-term, elderly patients with complex PHFs treated with RSA may have decreased pain, increased Constant-Murley scores, and increased ROM compared with patients treated non-operatively, at the expense of a higher risk of needing subsequent surgery. However, moderate between-study heterogeneity in effect sizes and the retrospective nature of included studies may limit the clinical applications of conclusions obtained in this review. Level of evidence III.
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Affiliation(s)
- Victor Yan Zhe Lu
- Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong
| | - Halia Shah
- St George's, University of London, SW17 0RE, United Kingdom
| | - Zainab Alshaber
- University of Glasgow Medical School, Glasgow, G12 8QQ, United Kingdom
| | - Aaron Limonard
- Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong
| | - Peter Domos
- Department of Trauma and Orthopaedics, Barnet and Chase Farm Hospital, Royal Free NHS Foundation Trust, London, NW3 2QG, United Kingdom
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12
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Kitaw TA, Getie A, Asgedom SG, Adisu MA, Tilahun BD, Zemariam AB, Alamaw AW, Faris AM, Habtie TE, Munie MA, Lake ES, Yilak G, Ayele M, Azmeraw M, Abate BB, Haile RN. Lower limb lymphoedema-related mental depression: A systematic review and meta-analysis of non-cancer-related studies. GLOBAL EPIDEMIOLOGY 2025; 9:100180. [PMID: 39834659 PMCID: PMC11743871 DOI: 10.1016/j.gloepi.2024.100180] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/27/2024] [Revised: 12/20/2024] [Accepted: 12/21/2024] [Indexed: 01/22/2025] Open
Abstract
Background Lower limb lymphoedema, characterized by persistent swelling in the legs due to lymphatic dysfunction, not only imposes a physical burden but is also associated with significant mental depression. While emerging research suggests a strong link between lower limb lymphoedema and depression, the extent of the problem remains underexplored. This study aims to investigate the relationship between lower limb lymphoedema and mental depression through a meta-analysis of existing studies. Methods A comprehensive search was conducted across databases including PubMed, MEDLINE, EMBASE, International Scientific Indexing, Web of Science, and Google Scholar. Study quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool. A weighted inverse variance random-effects model was used for pooled estimates, along with subgroup analysis, heterogeneity assessment, publication bias testing, and sensitivity analysis. The prediction interval was computed to estimate where future observations may fall. The review protocol was registered in PROSPERO (CRD42024541596). Results Thirteen studies involving 3503 patients with lower limb lymphoedema due to lymphatic filariasis, podoconiosis, or leprosy were included. The pooled estimate of depression related to lower limb lymphoedema was 38.4 % (95 % CI: 26.3 %, 50.5 %). High heterogeneity (I2 = 81.48 %) highlighted significant variability among the studies. Depression was more prevalent among leprosy patients (38.1 %) and podoconiosis patients (36.4 %), showing little difference between the two. However, the prevalence was notably lower among those with lymphatic filariasis (22.4 %). A higher prevalence of depression was found in Africa (39.4 %) compared to other regions (36.1 %). Conclusion Patients with lower limb lymphoedema experience disproportionately high rates of mental depression compared to the general population. Integrating mental health assessment and treatment into care packages for lymphoedema management is essential, with special attention needed for leprosy patients.
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Affiliation(s)
- Tegene Atamenta Kitaw
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Addisu Getie
- Department of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia
| | - Solomon Gebremichael Asgedom
- Department of Surgical Nursing, School of Nursing, College of Health Sciences and Comprehensive Specialized Hospital, Aksum University, Axum, Ethiopia
| | - Molalign Aligaz Adisu
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Befkad Derese Tilahun
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Alemu Birara Zemariam
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | | | - Abebe Merchaw Faris
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Tesfaye Engdaw Habtie
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Melesse Abiye Munie
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Eyob Shitie Lake
- Department of Midwifery, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Gizachew Yilak
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Mulat Ayele
- Department of Midwifery, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Molla Azmeraw
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
| | - Biruk Beletew Abate
- School of Population Health, Curtin University, Bentley, WA, Australia
- College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia
| | - Ribka Nigatu Haile
- Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia
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Okoli GN, Grossman Moon A, Soos AE, Neilson CJ, Kimmel Supron H, Etsell K, Grewal A, Van Caeseele P, Richardson C, Harper DM. Socioeconomic/health-related factors associated with HPV vaccination initiation/completion among females of paediatric age: A systematic review with meta-analysis. PUBLIC HEALTH IN PRACTICE 2025; 9:100562. [PMID: 39802391 PMCID: PMC11721234 DOI: 10.1016/j.puhip.2024.100562] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/24/2024] [Revised: 11/07/2024] [Accepted: 11/07/2024] [Indexed: 01/16/2025] Open
Abstract
Objectives To systematically identify, appraise, and summarise published evidence on individual socioeconomic and health-related factors associated with human papillomavirus (HPV) vaccination initiation and completion among females of paediatric age. Study design A global systematic review with meta-analysis (PROSPERO: CRD42023445721). Methods We performed a literature search in December 2022 and supplemented the search on August 1, 2023. Appropriate data were pooled using an inverse variance, random-effects model and the results were expressed as odds ratios, with 95 % confidence intervals. A statistically significant point pooled increased/decreased odds of 30-69 % was regarded to be strongly associated, and ≥70 % was very strongly associated. Results We included 83 cross-sectional studies. Among several significantly associated factors, being an older girl: 1.67 (1.44-1.93), having health insurance: 1.41 (1.16-1.72), and being in a public school: 1.54 (1.05-2.26) strongly increased the odds of vaccination initiation, and nativity in the country of study: 1.82 (1.33-2.50), use of contraception: 2.00 (1.16-3.46), receipt of influenza vaccination: 1.75 (1.54-2.00) and having visited a healthcare provider: 1.85 (1.51-2.28) in the preceding year very strongly increased the odds of vaccination initiation. Likewise, being an older girl: 1.36 (1.23-1.49) and having visited a healthcare provider in the preceding year: 1.46 (1.05-2.04) strongly increased the odds of vaccination series completion, and school-based vaccination: 3.08 (1.05-9.07), having health insurance: 1.72 (1.27-2.33), and receipt of influenza vaccination in the preceding year: 1.72 (1.62-1.83) very strongly increased the odds of vaccination series completion. We made similar observations when the studies were limited to the United States. Conclusions Several individual socioeconomic/health-related factors may determine initiating and completing the HPV vaccination series among paediatric females. These factors provide insights that may be key to identifying girls at increased risk of not being vaccinated and may aid targeted public health messaging.
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Affiliation(s)
- George N. Okoli
- Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
| | | | - Alexandra E. Soos
- University of Michigan Medical School, University of Michigan, Michigan, USA
| | | | | | - Katharine Etsell
- University of Michigan Medical School, University of Michigan, Michigan, USA
| | - Avneet Grewal
- University of Michigan Medical School, University of Michigan, Michigan, USA
| | - Paul Van Caeseele
- Department of Medical Microbiology & Infectious Diseases, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
| | | | - Diane M. Harper
- Departments of Family Medicine and Obstetrics & Gynecology, University of Michigan, Michigan, USA
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Sun AP, Ho CH, Kuss DJ, Cross CL. The temporal stability of problematic gaming and gaming disorder: A systematic review and meta-analysis. Addict Behav Rep 2025; 21:100592. [PMID: 40125549 PMCID: PMC11928845 DOI: 10.1016/j.abrep.2025.100592] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/09/2024] [Revised: 02/12/2025] [Accepted: 02/18/2025] [Indexed: 03/25/2025] Open
Abstract
Classifying problematic gaming/gaming disorder as a formal psychiatric diagnosis requires data on its level of temporal stability: are the dysfunctional symptoms transient or can they persist in the absence of treatment? To evaluate this question, we conducted a literature review and meta-analysis to investigate temporal stability in problematic gaming/gaming disorder. We identified 50 relevant longitudinal studies on PubMed, PsycINFO, and SCOPUS. Our review and meta-analysis engaged on two types of temporal stability: categorical stability and dimensional stability. We used MetaXL to run the meta-analysis for categorical stability. Our meta-analysis revealed that overall, the categorical stability rate was approximately 34-38% for the 2-year follow-up studies and approximately 43-45% for the 1-year follow-up studies. This indicates that between 1/3 and 1/2 of the gamers who initially met the threshold for problematic gaming/gaming disorder continued to meet such a threshold at follow-ups. Our meta-analysis included predominantly adolescent groups, which should be noted when generalizing the obtained categorical stability rates. Our review results also showed that overall, the dimensional stability was positive and statistically significant, indicating moderate or high correlations between symptom severity at baseline and at follow-ups. Temporal stability can be a complex concept. Our results suggest that although the categorical stability of problematic gaming/gaming disorder is not as strong as some major psychiatric disorders such as schizophrenia and bipolar disorder, it is similar to personality disorder and gambling disorder. Many complex factors may affect the temporal stability of problematic gaming/gaming disorder, possibly including severity of the disorder, whether the data is from clinical or nonclinical populations, and an individual's age group or developmental stage. More methodologically rigorous longitudinal studies that address these issues are needed.
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Affiliation(s)
- An-Pyng Sun
- School of Social Work, Greenspun College of Urban Affairs, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Las Vegas, Nevada 89154, United States
| | - Chih-Hsiang Ho
- Department of Mathematical Sciences, University of Nevada Las Vegas, 4505 S. Maryland Parkway, Las Vegas, Nevada 89154, United States
| | - Daria J. Kuss
- International Gaming Research Unit and Cyberpsychology Research Group, Department of Psychology, Nottingham Trent University, Chaucer CHR4017, 50 Shakespeare Street, Nottingham NG14FQ, UK
| | - Chad L. Cross
- School of Public Health, Department of Epidemiology & Biostatistics, University of Nevada Las Vegas, 4700 S. Maryland Parkway, Las Vegas, Nevada 89119, United States
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15
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Behr S, Martinez Garcia L, Lucas J, Kohlhase E, Puetz M, Boettcher J, Schaeuffele C, Knaevelsrud C. The role of self-efficacy in internet-based interventions for mental health: A systematic review and meta-analysis. Internet Interv 2025; 40:100821. [PMID: 40242832 PMCID: PMC12002610 DOI: 10.1016/j.invent.2025.100821] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/06/2025] [Revised: 03/20/2025] [Accepted: 03/21/2025] [Indexed: 04/18/2025] Open
Abstract
Introduction Internet-based interventions (IBI) increase access to evidence-based treatments for mental disorders, but knowledge of their mechanisms of change is limited. Self-efficacy, a key factor in psychotherapy, is especially relevant in IBI due to its self-help focus. We investigated self-efficacy and related constructs as outcomes, predictors/moderators, and mediators in randomized controlled trials. Methods A systematic search was conducted across PsycINFO, PubMed, CINAHL, and Web of Science. Two reviewers selected studies, extracted data, and assessed bias. Effects were quantified using random effect models and supplemented by narrative syntheses and box score visualizations. Results 70 studies (N = 17,407 participants) were included. IBI showed moderate effects on self-efficacy in within (d = 0.47) and between (d = 0.46) comparisons, with guided interventions having the largest effect (d = 0.66). Findings on self-efficacy as a predictor/moderator were mixed, though some studies suggested individuals with lower self-efficacy benefit more. Self-efficacy emerged as a mediator through which IBI affected treatment outcomes. Conclusion Self-efficacy appears influential in IBI efficacy and may itself be a valuable treatment target. However, mixed results and methodological limitations in mediator studies highlight the need for further research, particularly on long-term effects.
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Affiliation(s)
- Solveig Behr
- Department of Education and Psychology, Freie Universitaet Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany
| | - Laura Martinez Garcia
- Department of Psychology and Sociology, Universidad de Zaragoza, C/Atarazanas, 4, 44003 Teruel, Spain
| | - Julia Lucas
- Department of Education and Psychology, Freie Universitaet Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany
| | - Esther Kohlhase
- Department of Education and Psychology, Freie Universitaet Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany
| | - Marie Puetz
- Department of Psychology and Psychotherapy, Psychologische Hochschule Berlin, Am Köllnischen Park 2, 10179 Berlin, Germany
| | - Johanna Boettcher
- Department of Psychology and Psychotherapy, Psychologische Hochschule Berlin, Am Köllnischen Park 2, 10179 Berlin, Germany
| | - Carmen Schaeuffele
- Department of Education and Psychology, Freie Universitaet Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany
| | - Christine Knaevelsrud
- Department of Education and Psychology, Freie Universitaet Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany
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16
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Wang N, Zhao TY, Ma X. Increased colorectal cancer risk in prediabetes: A meta-analysis. World J Diabetes 2025; 16:103403. [DOI: 10.4239/wjd.v16.i5.103403] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/18/2024] [Revised: 01/21/2025] [Accepted: 02/21/2025] [Indexed: 04/25/2025] Open
Abstract
BACKGROUND Previous research yielded conflicting results regarding the association between prediabetes and colorectal cancer (CRC).
AIM To systematically assess the incidence of CRC in individuals with prediabetes compared with individuals with normoglycemia via a meta-analysis.
METHODS Relevant cohort studies were acquired by searching MEDLINE, Web of Science, and EMBASE. A random-effects model was applied to combine the findings after accounting for heterogeneity. Several subgroup analyses were conducted to assess the impact of study characteristics on the results.
RESULTS Eleven cohort studies involving 4996352 participants, including 383917 (7.7%) with prediabetes at baseline, were analyzed in this meta-analysis. Over a mean follow-up period of 6.5 years, the combined findings revealed that individuals with prediabetes at baseline had a higher likelihood of developing CRC than those with normoglycemia [risk ratio (RR) = 1.18, 95% confidence interval = 1.11 to 1.25, P < 0.001] with low statistical heterogeneity (I2 = 27%). Subgroup analyses indicated that the association between prediabetes and an increased risk of CRC was mainly observed in studies defining prediabetes using impaired fasting glucose (RR = 1.24) and slightly elevated hemoglobin A1c levels (RR = 1.18) but not in those that defined prediabetes using impaired glucose tolerance (RR = 1.06). Other study characteristics such as design, country, participant age and sex, the duration of follow-up, or adjustment for body mass index did not significantly impact the results (all P > 0.05).
CONCLUSION People with prediabetes might have a higher likelihood of developing CRC than individuals with normoglycemia.
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Affiliation(s)
- Na Wang
- Physical Examination Center, China-Japan Friendship Hospital, Beijing 100029, China
| | - Tian-Yi Zhao
- Physical Examination Center, China-Japan Friendship Hospital, Beijing 100029, China
| | - Xiao Ma
- Physical Examination Center, China-Japan Friendship Hospital, Beijing 100029, China
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Niu L, Gao Q, Xie M, Yip T, Gunnar MR, Wang W, Xu Q, Zhang Y, Lin D. Association of childhood adversity with HPA axis activity in children and adolescents: A systematic review and meta-analysis. Neurosci Biobehav Rev 2025; 172:106124. [PMID: 40157436 DOI: 10.1016/j.neubiorev.2025.106124] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/27/2025] [Revised: 03/19/2025] [Accepted: 03/22/2025] [Indexed: 04/01/2025]
Abstract
Childhood adversity (CA) is associated with alteration of the hypothalamus-pituitary-adrenal (HPA) axis. We conducted a meta-analysis to synthesize existing evidence on the association between CA and HPA axis activity among children and adolescents and investigate four research questions: (1) Is CA associated with different aspects of the HPA axis (i.e., diurnal cortisol, acute stress response, chronic cortisol levels)?, (2) Does this association vary by the child's age?, (3) Are threat and deprivation dimensions of CA differentially associated with HPA axis activity?, and (4) Does this association depend on both the dimension and timing of CA? Meta-analyses were conducted with 129 studies reporting 506 effect sizes. Results showed significant associations between CA with higher afternoon cortisol levels (r = 0.053), a flatter diurnal slope (r = 0.048), more blunted reactivity (r = -0.043), and higher hair cortisol concentration (r = 0.098), but not other cortisol indicators (morning cortisol, cortisol awakening response, daily output, and cortisol recovery). Older children and adolescents had more pronounced blunted reactivity and steeper recovery with CA than younger children. Threat and deprivation did not differ in overall impact for any cortisol indicator; however, there are timing-dependent associations specific to threat or deprivation for some cortisol indicators. For instance, threat was associated with heightened reactivity when occurred before middle childhood, and with blunted reactivity when occurred after age 15 years; in contrast, deprivation was associated with blunted reactivity regardless of its timing. Findings could inform targeted interventions to reduce negative impacts of CA on development.
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Affiliation(s)
- Li Niu
- Faculty of Psychology, Beijing Normal University, Beijing, China
| | - Qianqian Gao
- Faculty of Psychology, Beijing Normal University, Beijing, China
| | - Mingjun Xie
- Faculty of Psychology, Beijing Normal University, Beijing, China
| | - Tiffany Yip
- Department of Psychology, Fordham University, NY, USA
| | - Megan R Gunnar
- Institute of Child Development, University of Minnesota, MN, USA
| | - Wei Wang
- Faculty of Psychology, Beijing Normal University, Beijing, China
| | - Qinglin Xu
- Faculty of Psychology, Beijing Normal University, Beijing, China; Mental Health Education and Counseling Center, Beijing Wuzi University, Beijing, China
| | - Yanjia Zhang
- Faculty of Psychology, Beijing Normal University, Beijing, China
| | - Danhua Lin
- Institute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China.
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Ge X, Li Y, Zhao F, Ma X, Li J, Jiang Y, Cui W, Wang X, Tang L. Global prevalence of Porcine Astrovirus: A systematic review and meta-analysis. Prev Vet Med 2025; 238:106465. [PMID: 39954603 DOI: 10.1016/j.prevetmed.2025.106465] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2024] [Revised: 01/17/2025] [Accepted: 02/11/2025] [Indexed: 02/17/2025]
Abstract
Porcine astrovirus (PAstV) is a widespread enteric virus in pigs, often co-infecting with other enteric viruses and contributing to diarrhea, leading to significant economic losses in the global swine industry. This study aims to identify the factors influencing PAstV prevalence by conducting a statistical meta-analysis of global data and evaluating heterogeneity across various subgroups. A systematic literature search was performed across PubMed, Web of Science, CNKI, Wanfang, and VIP databases, covering studies from the inception of the databases up to December 2023. A random-effects model was employed to estimate the global pooled prevalence of PAstV infection, and subgroup analyses were performed to evaluate the impact of different continents, years, detection methods, and sample types on the prevalence. Publication bias was assessed using a funnel plot and Egger's test. A total of 45 studies from 10 countries across three continents, involving 376 articles, were included in the meta-analysis. The global pooled prevalence of PAstV infection was found to be 28.19 % (95 % CI, 21.94 %-34.89 %). Subgroup analysis indicated significant differences in PAstV prevalence across continents, with Asia at 26.25 % (95 % CI, 25.41 %-27.09 %), Europe at 36.19 % (95 % CI, 34.09 %-38.33 %), and North America at 63.24 %. The prevalence of PAstV was highest between 2012 and 2014 (49.86 %, 95 % CI, 47.21 %-52.51 %), followed by a decreasing trend that stabilized below 30 % from 2015 to 2023. The analysis showed no significant influence of detection methods on PAstV prevalence. However, the prevalence in non-fecal samples (43.09 %, 95 % CI: 41.05 %-45.15 %) was significantly higher than in fecal samples (22.92 %, 95 % CI: 21.87 %-23.99 %). Additionally, the prevalence of PAstV in asymptomatic pigs (36.71 %, 95 % CI, 34.97 %-38.48 %) exceeded that in diarrheic pigs (28.18 %, 95 % CI, 26.94 %-29.44 %). Among different age groups, nursery pigs(6-10 weeks) exhibited the highest infection rate (63.19 %, 95 % CI, 58.45 %-67.75 %), followed by weaning pigs(3-6 weeks) (60.00 %, 95 % CI, 56.48 %-63.45 %), finisher pigs(>10 weeks) (49.89 %, 95 % CI, 46.59 %-53.19 %), sows (35.33 %, 95 % CI, 31.45 %-39.37 %), with suckling pigs(0-3 weeks) showing the lowest rate (31.93 %, 95 % CI, 30.23 %-33.68 %). This study highlights the widespread nature of PAstV infection in pig populations globally, with notable variations in prevalence across regions, years, and sample types. The high prevalence of asymptomatic infections underscores the need for enhanced PAstV surveillance and control measures.
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Affiliation(s)
- Xiaoyu Ge
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
| | - Yize Li
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
| | - Feipeng Zhao
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
| | - Xin'ao Ma
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China
| | - Jiaxuan Li
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Northeast Science Observation Station for Animal Pathogen Biology, Ministry of Agriculture and Rural Affairs, Harbin 150030, China
| | - Yanping Jiang
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Northeast Science Observation Station for Animal Pathogen Biology, Ministry of Agriculture and Rural Affairs, Harbin 150030, China
| | - Wen Cui
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Northeast Science Observation Station for Animal Pathogen Biology, Ministry of Agriculture and Rural Affairs, Harbin 150030, China
| | - Xiaona Wang
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Northeast Science Observation Station for Animal Pathogen Biology, Ministry of Agriculture and Rural Affairs, Harbin 150030, China.
| | - Lijie Tang
- College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Northeast Science Observation Station for Animal Pathogen Biology, Ministry of Agriculture and Rural Affairs, Harbin 150030, China.
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Berry R, Harmouch KM, Roto A, Kumar N, Khan Z, Khanal R, Hamza M, Bahar Y, Sattar Y, Aljaroudi W, Paul TK, Alraies MC. Morphine and P2Y12 Inhibitors in ST-Elevation Myocardial Infarction: An Updated Meta-Analysis. Am J Cardiovasc Drugs 2025; 25:389-398. [PMID: 39702685 DOI: 10.1007/s40256-024-00708-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 11/23/2024] [Indexed: 12/21/2024]
Abstract
BACKGROUND Morphine is used to control pain in ST-elevation myocardial infarction but reduces P2Y12 inhibition. It is not known if this modulation of platelet inhibition appreciably affects clinical outcomes. METHODS We screened 979 articles and identified seven studies that met the eligibility criteria for meta-analysis. Outcomes included 11 metrics across angiographic and clinical domains. A random effects model assessed heterogeneity between studies. RESULTS The opiate group showed decreased achievement of postprocedural thrombolysis in myocardial infarction (TIMI) 2 flow relative to placebo [risk ratio (RR) 0.71, 95% confidence interval (CI) 0.52-0.97, p = 0.03, I2 = 0.0%]. All other metrics listed below showed no statistically significant difference between groups: infarct size, microvascular obstruction, microvascular/salvage index, absence of pre- percutaneous coronary intervention (PCI) TIMI 3 flow, postprocedural TIMI 2 flow, postprocedural TIMI 3 flow, all-cause mortality, stroke, repeat MI, unstable angina, and left ventricular ejection fraction. However, there were no statistically significant differences in infarct size [odds ratio (OR) - 0.12, 95% CI - 0.37 to 0.17, p = 0.42], microvascular obstruction [standard mean difference (SMD) = 0.02, 95% CI - 0.12 to 0.16, p = 0.82], microvascular obstruction/salvage index (SMD = - 0.05, 95% CI - 0.24 to 0.13, p = 0.57), absence of pre-PCI TIMI 3 flow (OR 0.98, 95% CI 0.79-1.22, p = 0.87), and postprocedural TIMI 3 flow (OR 1.23, 95% CI 0.84-1.79, p = 0.28) between the two groups. CONCLUSIONS In STEMI, opiates correlate with worse angiographic outcomes, specifically postprocedural TIMI 2 flow. However, this observation does not appear to be clinically consequential.
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Affiliation(s)
- Ryan Berry
- Authority Health, Detroit Medical Center-Sinai Grace, Michigan State University, Detroit, MI, USA
| | - Khaled M Harmouch
- Department of Internal Medicine, DMC Sinai Grace, Wayne State School of Medicine, Detroit, MI, USA
| | - Alaa Roto
- Department of Internal Medicine, DMC Sinai Grace, Wayne State School of Medicine, Detroit, MI, USA
| | - Nomesh Kumar
- Department of Internal Medicine, DMC Sinai Grace, Wayne State School of Medicine, Detroit, MI, USA
| | - Zohaib Khan
- Department of Internal Medicine, DMC Sinai Grace, Wayne State School of Medicine, Detroit, MI, USA
| | - Resha Khanal
- Department of Internal Medicine, DMC, Wayne State University, Detroit, MI, USA
| | | | | | - Yasar Sattar
- Division of Cardiology, West Virginia University, Morgantown, WV, USA
| | - Wael Aljaroudi
- Division of Cardiovascular Medicine, WellStar-Medical College of Georgia, Augusta, GA, USA
| | - Timir K Paul
- Department of Cardiovascular Sciences, Ascension St. Thomas Hospital-Nashville, University of Tennessee, Nashville, TN, USA
| | - M Chadi Alraies
- Cardiovascular Institute, Detroit Medical Center, Heart Hospital, Wayne State University, 311 Mack Ave, Detroit, MI, 48201, USA.
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20
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Brunyé TT, Goring SA, Navarro E, Hart-Pomerantz H, Grekin S, McKinlay AM, Plessow F. Identifying the most effective acute stress induction methods for producing SAM- and HPA-related physiological responses: a meta-analysis. ANXIETY, STRESS, AND COPING 2025; 38:263-285. [PMID: 39788724 DOI: 10.1080/10615806.2025.2450620] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 06/07/2024] [Revised: 01/02/2025] [Accepted: 01/03/2025] [Indexed: 01/12/2025]
Abstract
BACKGROUND AND OBJECTIVES Laboratory-based stress inductions are commonly used to elicit acute stress but vary widely in their procedures and effectiveness. We compared the effects of stress induction techniques on measures of two major biological stress systems: the early sympathetic-adrenal-medullary (SAM) and the delayed hypothalamic-pituitary-adrenal (HPA) axis response. DESIGN A review and meta-analysis to examine the relationship between stress induction techniques on cardiorespiratory and salivary measures of SAM and HPA system activity. METHODS A systematic literature search identified 245 reports and 700 effects. RESULTS The overall effect of stress induction techniques on the stress response was moderate (Fisher's zr = 0.44), inducing stronger SAM-related (zr = 0.48) versus HPA-related (zr = 0.37) responses. Three factors moderated these associations: the stress system examined (SAM vs HPA), the specific stress induction technique employed (e.g., Cold Pressor), the physiological sampling time relative to the stress induction, and participant sex. Loud music elicited the most robust SAM-related effects, whereas combined stress inductions elicited the most robust HPA-related effects. Men showed stronger stress responses than women. CONCLUSIONS Stress induction techniques variably elicit SAM - and HPA-related responses. Results recommend specific induction techniques for targeting stress systems, highlighting the importance of carefully selecting methodologies in laboratory contexts.
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Affiliation(s)
- Tad T Brunyé
- Cognitive Science and Applications Branch, U.S. Army DEVCOM Soldier Center, Natick, MA, USA
- Center for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, USA
| | - Sara Anne Goring
- Center for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, USA
| | - Ester Navarro
- Center for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, USA
- Department of Psychology, St. John's University, New York, NY, USA
| | | | - Sophia Grekin
- Center for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, USA
| | - Alexandra M McKinlay
- Center for Applied Brain and Cognitive Sciences, Tufts University, Medford, MA, USA
- Department of Psychology, McGill University, Montreal, Canada
| | - Franziska Plessow
- Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
- Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA
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21
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Fawzy M, Elsuity MA, Magdi Y, Rashwan MM, Gad MA, Adel N, Emad M, Ibrahem D, El-Gezeiry S, Etman A, Ahmed NS, Abdelhamed T, El-Damen A, Mahran A, Serour GI, Soliman MY. Evaluating the Effectiveness of Assisted Oocyte Activation in ICSI: Pairwise Meta-Analyses and Systematic Evidence Evaluation. BJOG 2025; 132:724-741. [PMID: 39888192 DOI: 10.1111/1471-0528.18085] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/25/2024] [Revised: 01/15/2025] [Accepted: 01/18/2025] [Indexed: 02/01/2025]
Abstract
BACKGROUND Artificial oocyte activation (AOA) is used to improve fertilisation rates in intracytoplasmic sperm injection (ICSI) cycles. OBJECTIVES To assess the effectiveness of AOA on fertilisation, embryo development, and clinical outcomes, including live birth. SEARCH STRATEGY We searched PubMed, Cochrane, and Scopus from January 1990 to March 2024 using terms related to 'artificial oocyte activation' and 'ICSI.' SELECTION CRITERIA Study designs included randomised trials (RCTs), quasi-experimental, cohort, and case-control studies that evaluated AOA's effects on ICSI outcomes, provided quantitative data and were published in English. DATA COLLECTION AND ANALYSIS Reviewers independently performed data extraction using a standardised form. Study quality was appraised using Joanna Briggs Institute (JBI) Checklists. Meta-analyses employed a random-effects model, and evidence was classified using a comprehensive numerical framework. MAIN RESULTS We included 45 studies covering 56 787 mature oocytes, 7463 women for clinical pregnancies, and 7063 women for live births. AOA showed potential in increasing fertilisation rates in patients with a history of low or absent fertilisation but did not enhance embryo development or clinical outcomes. This effect diminished when excluding low-quality studies or focusing solely on RCTs. In other patient groups, AOA showed limited or nonsignificant benefits. CONCLUSIONS Applying comprehensive evidence assessment, AOA showed potential in improving fertilisation rates in patients with fertilisation problems but no benefits for embryo development or live birth rates. This underscores the critical importance of rigorous evidence credibility in informing clinical practice in assisted conception.
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Affiliation(s)
- Mohamed Fawzy
- IbnSina (Sohag), Banon (Assiut), Amshag (Sohag) IVF Facilities, Egypt
| | - Mohamad AlaaEldein Elsuity
- IbnSina (Sohag), Banon (Assiut), Amshag (Sohag) IVF Facilities, Egypt
- Department of Dermatology, Venereology and Andrology, Sohag University, Sohag, Egypt
| | - Yasmin Magdi
- Al-Yasmeen Fertility and Gynecology Center, Benha, Egypt
| | - Mosab Mahmod Rashwan
- IbnSina (Sohag), Banon (Assiut), Amshag (Sohag) IVF Facilities, Egypt
- Department of Forensic Medicine and Clinical Toxicology, Sohag University, Sohag, Egypt
| | - Mostafa Ali Gad
- IbnSina (Sohag), Banon (Assiut), Amshag (Sohag) IVF Facilities, Egypt
| | - Nehal Adel
- Madina Fertility Center, Madina Women Hospital, Alexandria, Egypt
| | - Mai Emad
- IbnSina (Sohag), Banon (Assiut), Amshag (Sohag) IVF Facilities, Egypt
| | | | | | | | | | | | | | - Ali Mahran
- Department of Andrology, Assiut University, Asyut, Egypt
| | - Gamal I Serour
- Department of Obstetrics and Gynaecology, International Islamic Center, Al Azhar University, Egyptian IVF-ET Center, Cairo, Egypt
| | - Mohamed Y Soliman
- Obstetrics and Gynaecology Department, Ain Shams University, Cairo, Egypt
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Bifftu BB, Thomas SJ, Win KT. Users' positive attitudes, perceived usefulness, and intentions to use digital mental health interventions: A systematic literature review and meta-analysis. Comput Biol Med 2025; 190:110080. [PMID: 40158460 DOI: 10.1016/j.compbiomed.2025.110080] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/06/2024] [Revised: 02/28/2025] [Accepted: 03/24/2025] [Indexed: 04/02/2025]
Abstract
BACKGROUND Digital Mental Health Interventions (DMHIs) hold significant potential in addressing gaps in mental health treatment, enhancing mental health literacy, and mitigating associated stigma. However, DMHIs have not been systematically evaluated in terms of potential users' attitudes, perceived usefulness, and intentions to use. Thus, this study aims to consolidate evidence to ascertain users' attitudes, perceived usefulness, and intentions to utilize DMHIs. METHODS The meta-analysis reports adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. A comprehensive search of databases: Medline, CINHAL, PsycINFO, SCOPUS, and Web of Science, was conducted. As part of the screening process, Covidence database management software was used. Metaprop command was used to calculate the outcome using a random-effects model. Heterogeneity was assessed using Cochrane chi-square (χ2) and the index of heterogeneity (I2 statistics) test. Sensitivity test and subgroup analysis were performed. Publication bias was examined by funnel plots and Egger's test. RESULTS In total, 26 studies were analyzed, including data from 13,923 participants. The overall percentage of users' positive attitudes, perceived usefulness, and intentions to use DHMIs was 0.66 (95 % CI; 0.52, 0.79), 0.73 (95 % CI; 0.64, 0.81), and 0.67 (95 % CI; 0.6, 0.74), respectively. Significant heterogeneity was observed; nonetheless, sensitivity analyses indicated that none of the included individual studies exerted undue influence on the overall pooled prevalence. Assessment of funnel plots and Egger's test (p ≤ 0.895) showed no evidence of publication bias. CONCLUSION The results of this meta-analysis indicate that, overall, two-thirds of participants have a positive attitude toward DMHIs, around three-quarters find DMHIs useful, and around two-thirds intend to use them. The findings suggest the need to target users' positive attitudes, perceived utility, and willingness for the improved adoption and sustained use of DMHIs.
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Affiliation(s)
- Berhanu Boru Bifftu
- University of Gondar College of Medicine and Health Science, School of Nursing, Gondar, Ethiopia; University of Wollongong Faculty of Engineering and Information Sciences, Wollongong, Australia.
| | - Susan J Thomas
- University of Wollongong Faculty of Science Medicine and Health, Wollongong, Australia.
| | - Khin Than Win
- University of Wollongong Faculty of Engineering and Information Sciences, Wollongong, Australia.
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Seyyedsalehi MS, Bonetti M, Shah D, DeStefano V, Boffetta P. Occupational benzene exposure and risk of kidney and bladder cancers: a systematic review and meta-analysis. Eur J Cancer Prev 2025; 34:205-213. [PMID: 39229942 PMCID: PMC11949222 DOI: 10.1097/cej.0000000000000911] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/28/2024] [Accepted: 07/10/2024] [Indexed: 09/05/2024]
Abstract
INTRODUCTION Benzene is recognized as leukemogenic. However, the association between it and solid cancers has been the subject of less investigation. We aim to conduct a systematic review and meta-analysis to evaluate the association between occupational exposure to benzene and the risk of urinary tract cancer, including kidney and bladder. METHODS We included 41 cohort and case-control studies listed in the most recent International Agency for Research on Cancer (IARC) Monograph on benzene exposure and the result of a literature review to identify more recent studies. Forest plots of relative risk (RR) were constructed for kidney, bladder, and urinary tract cancer overall. A random-effects model was used to address heterogeneity between studies. Stratified analyses were conducted to explore effect modification. RESULTS Our findings revealed an association between exposure to occupational benzene and kidney and unspecified urinary tract cancers (RR = 1.20, 95% confidence interval = 1.03-1.39), and an association of borderline statistical significance with bladder cancer (RR = 1.07, 95% confidence interval = 0.97-1.18). Publication bias was excluded for both kidney ( P = 0.809) and bladder cancer ( P = 0.748). Stratification analysis according to the selected study characteristics showed no difference except regarding the industry for kidney cancer ( P < 0.000), with a stronger association in the chemical industry. An analysis by exposure level did not reveal any trend for kidney cancer, whereas there was a trend ( P = 0.01) for bladder cancer. CONCLUSION Our study found an association between occupational benzene exposure and kidney cancer and a dose-effect association between benzene exposure and bladder cancer.
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Affiliation(s)
| | - Mattia Bonetti
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
| | - Darshi Shah
- Department of Family, Population and Preventive Medicine, Renaissance School of Medicine
| | - Vincent DeStefano
- Department of Family, Population and Preventive Medicine, Renaissance School of Medicine
| | - Paolo Boffetta
- Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
- Department of Family, Population and Preventive Medicine, Renaissance School of Medicine
- Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA
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24
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Hüntermann R, Fischer-Bacca CO, Alves MF, Livramento Junior VA, Alexandrino FB, Sato MY, Gomes RF, Rocha FR, Gambetta MV, Melo ES. Sacubitril-valsartan in Cancer therapy-induced heart failure: A systematic review and meta-analysis of functional and hemodynamic parameters. Curr Probl Cardiol 2025; 50:102987. [PMID: 39828108 DOI: 10.1016/j.cpcardiol.2025.102987] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/09/2025] [Accepted: 01/16/2025] [Indexed: 01/22/2025]
Abstract
BACKGROUND Cancer therapy-induced cardiotoxicity (CTRCD), in the form of heart failure with reduced ejection fraction (HFrEF), is being increasingly recognized. However, the potential benefits of sacubitril/valsartan (S/V) in managing HFrEF secondary to CTRCD remain unclear. OBJECTIVE We performed a systematic review and meta-analysis to assess the effectiveness of S/V in preventing cardiotoxicity. METHODS We searched PubMed, Embase, and Cochrane databases for studies evaluating S/V in patients with HFrEF due to CTRCD and reporting the following outcomes: (1) NYHA class; (2) NT-ProBNP and (3) echocardiographic measurements, specifically left ventricular ejection fraction (LVEF), global longitudinal strain (GLS) and E/e' ratio. Statistical analyses were performed using RStudio software. Heterogeneity was assessed using I² statistics. RESULTS We included 257 patients from six studies. All patients received S/V. The mean patient age was 63 ± 8 years, and 85 % of patients had breast cancer. The mean LVEF was 34±7 % at baseline. S/V significantly improved NYHA class compared to baseline (MD -0.7; 95 % CI -1.2 to -0.3; p < 0.01), NT-proBNP (MD -985.1 pg/mL; 95 % CI -1231.3 to -739.1; p < 0.01), GLS (MD -2.5 %; 95 % CI -3.6 to -1.4; p < 0.01;), and E/e' (MD -1.99; 95 % CI 3.7 to -0.1; p = 0.03). LVEF (MD 7.3 %; 95 % CI 5.4 to 9.2; p < 0.01) with S/V treatment relative to baseline. CONCLUSION In patients with HFrEF due to CTRCD, S/V significantly improved the clinical and echocardiographic parameters of left ventricular systolic and diastolic functions.
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Affiliation(s)
- Ramon Hüntermann
- Medical Sciences Research Center, University Center for the Development of Alto Vale - Rio do Sul - Brazil.
| | - Caroline O Fischer-Bacca
- Medical Sciences Research Center, University Center for the Development of Alto Vale - Rio do Sul - Brazil
| | - Marcel F Alves
- Medical Sciences Research Center, University Center for the Development of Alto Vale - Rio do Sul - Brazil
| | | | | | | | | | - Franciani R Rocha
- Medical Sciences Research Center, University Center for the Development of Alto Vale - Rio do Sul - Brazil
| | - Marcelo V Gambetta
- Medical Sciences Research Center, University Center for the Development of Alto Vale - Rio do Sul - Brazil
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Ezzatvar Y, Caballero Ó, Duclos-Bastias D, Yáñez-Sepúlveda R, García-Hermoso A. Loneliness and social isolation as risk factors for type 2 diabetes onset: A systematic review and meta-analysis. Diabetes Res Clin Pract 2025; 223:112124. [PMID: 40122178 DOI: 10.1016/j.diabres.2025.112124] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/25/2024] [Revised: 03/14/2025] [Accepted: 03/20/2025] [Indexed: 03/25/2025]
Abstract
AIMS This study sought to analyze the association of social isolation and loneliness with the risk of type 2 diabetes onset. METHODS Two authors systematically searched PubMed, EMBASE, and Web of Science databases for studies published until February 2025, assessing the risk of incidence of type 2 diabetes in individuals who are socially isolated or lonely. To quantify the risk of incident diabetes, hazard ratios (HR) for loneliness and social isolation were pooled using a random-effects inverse-variance model with empirical Bayes estimation. RESULTS Nine prospective cohort studies were included, comprising 1,112,887 individuals (60.5 % female, mean age = 57.1 years), with 50,961 new cases of type 2 diabetes over a mean follow-up of 10.7 years. Loneliness was associated with a 32% increased risk of type 2 diabetes (HR = 1.32 [95 % confidence interval [CI]:1.11-1.57]). Social isolation was linked to a 20% higher risk (HR = 1.20 [95 %CI:1.01-1.43]). The included studies showed fair-to-good methodological quality (mean score: 10.11/14) based on the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. CONCLUSIONS Social isolation and loneliness are significant risk factors for type 2 diabetes. Addressing social connectedness could be a valuable strategy for diabetes prevention, emphasizing the need to incorporate psychosocial factors into public health initiatives.
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Affiliation(s)
- Yasmin Ezzatvar
- Lifestyle factors with impact on Ageing and overall Health (LAH) Research Group. Department of Nursing. University of València, Valencia, Spain
| | - Óscar Caballero
- Department of Nursing. University of València, Valencia, Spain
| | - Daniel Duclos-Bastias
- iGEO Group, School of Physical Education, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile; IGOID Research Group, Faculty of Sport Science, University of Castilla-La Mancha, Toledo, Spain
| | | | - Antonio García-Hermoso
- Navarrabiomed, Hospital Universitario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain.
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Li S, Jia J, Xu B, Wang X. Effects of chronic exercise on different central features of depression in adults with depression: A systematic review and meta-analysis of random controlled trials. PSYCHOLOGY OF SPORT AND EXERCISE 2025; 78:102824. [PMID: 39923828 DOI: 10.1016/j.psychsport.2025.102824] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/08/2024] [Revised: 12/19/2024] [Accepted: 01/14/2025] [Indexed: 02/11/2025]
Abstract
BACKGROUND Exercise is considered an effective treatment for improving central symptoms of depression. However, the antidepressant effects of exercise on specific central features in adults with depression and the optimal exercise prescription remain unclear. The present review aimed to explore the impact of exercise on emotion regulation (ER) and executive function (EF) among adults living with depression as well as the moderating effects of exercise prescription characteristics. METHODS Two Chinese databases and two English databases were systematically searched from January 1, 2000 to October 30, 2023 to identify relevant randomized controlled trials (RCTs). Based on the results of heterogeneity analyses, the random effects model was used for the meta-analysis of rumination (260 participants in 5 studies), inhibition (578 participants in 7 studies) and updating (832 participants in 9 studies), whereas the fixed effects model was used for the meta-analysis for shifting (802 participants in 8 studies). RESULTS Exercise improved rumination (standardized mean difference [SMD] = -0.59, p = 0.02); however, these benefits were observed only for moderate-intensity aerobic exercise in one or two 31-60 min sessions per week for 5-8 weeks. The results indicated significant post-exercise improvement in shifting (SMD = -0.22, p = 0.002) but not inhibition (SMD = -0.21, p = 0.18) or updating (SMD = 0.15, p = 0.14). Moreover, substantial improvements in shifting were observed only from high-intensity aerobic exercise in three or four 31-60 min sessions per week for more than 8 weeks. CONCLUSIONS Exercise improved ER (i.e., rumination) and EF (i.e., shifting) in adults with depression. It is important to consider symptoms when prescribing exercise to adults with depression. However, given the limited number of included RCTs, these findings are preliminary and tentative.
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Affiliation(s)
- Shuhua Li
- School of Psychology, Shanghai University of Sport, Shanghai, 200438, China
| | - Jiafeng Jia
- School of Psychology, Shanghai University of Sport, Shanghai, 200438, China
| | - Bingrui Xu
- School of Psychology, Shanghai University of Sport, Shanghai, 200438, China
| | - Xiaochun Wang
- School of Psychology, Shanghai University of Sport, Shanghai, 200438, China.
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Zhang J, Li Z, Wang N, Zhang P, Li Y, Chen Y. Efficacy and safety of stereotactic radiosurgery for idiopathic glossopharyngeal neuralgia: A systematic review and meta-analysis. Clin Neurol Neurosurg 2025; 252:108878. [PMID: 40184818 DOI: 10.1016/j.clineuro.2025.108878] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/15/2025] [Revised: 03/18/2025] [Accepted: 03/27/2025] [Indexed: 04/07/2025]
Abstract
BACKGROUND We performed this study to comprehensively assess the efficacy and safety of stereotactic radiosurgery (SRS) in patients with glossopharyngeal neuralgia (GPN). METHODS Searches of PubMed, Embase, Cochrane Library, and Web of Science were performed from inception to date. The protocol for this study was registered with the PROSPERO international prospective register of systematic reviews. RESULTS A total of seven studies involving 79 patients were included. At the last follow-up, the pooled proportion of patients achieving Barrow Neurological Institute (BNI) grade I was 37.5 % (95 % CI: 26.2 %-49.3 %). The proportion of patients attaining BNI grades I-IIIa was 58.5 % (95 % CI: 46.6 %-70.1 %). In terms of treatment failure, the pooled rate was 11.9 % (95 % CI: 4.6 %-21.3 %). Regarding recurrence, the pooled rate was 23.1 % (95 % CI: 13.4 %-34.0 %). The pooled complication rate was 0.2 % (95 % CI: 0.0 %-4.4 %). Among those who experienced treatment failure after microvascular decompression (MVD), 41.67 % (5/12) reached BNI grades I-IIIb, while 66.67 % (4/6) of those who failed rhizotomy achieved BNI grades I-IIIa. A total of 18 patients underwent repeat SRS; Of these, 44.4 % (8/18) achieved BNI grade I, and 66.7 % (12/18) attained BNI grades I-IIIa. CONCLUSION This study demonstrated that SRS is an acceptable treatment for idiopathic GPN, offering effective pain relief with an extremely low complication rate. It could serve as a valuable salvage therapy for those who have not achieved success with MVD or rhizotomy. Repeat SRS remains effective for patients experiencing recurrence.
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Affiliation(s)
- Jie Zhang
- Department of Neurophysiology, Cangzhou Central Hospital, No.16 Xinhua Road, Yunhe District, Cangzhou, Hebei Province 061000, China
| | - Zonghao Li
- Department of Neurosurgery, Cangzhou Central Hospital, No.16 Xinhua Road, Yunhe District, Cangzhou, Hebei Province 061000, China.
| | - Ning Wang
- Department of Neurophysiology, Cangzhou Central Hospital, No.16 Xinhua Road, Yunhe District, Cangzhou, Hebei Province 061000, China
| | - Peihua Zhang
- Department of Neurosurgery, Cangzhou Central Hospital, No.16 Xinhua Road, Yunhe District, Cangzhou, Hebei Province 061000, China
| | - Yongzhen Li
- Department of Neurosurgery, Cangzhou Central Hospital, No.16 Xinhua Road, Yunhe District, Cangzhou, Hebei Province 061000, China
| | - Yonghan Chen
- Department of Neurosurgery, Cangzhou Central Hospital, No.16 Xinhua Road, Yunhe District, Cangzhou, Hebei Province 061000, China
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Souza M, Al-Sharif L, Diaz I, Mantovani A, Villela-Nogueira CA. Global Epidemiology and Implications of PNPLA3 I148M Variant in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-analysis. J Clin Exp Hepatol 2025; 15:102495. [PMID: 39882540 PMCID: PMC11773032 DOI: 10.1016/j.jceh.2024.102495] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/03/2024] [Accepted: 12/18/2024] [Indexed: 01/31/2025] Open
Abstract
Background & Aims PNPLA3 rs738409 variant is a risk factor for onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to assess its global prevalence, clinical and histological characteristics, and long-term outcomes in patients with MASLD. Methods PubMed and Embase databases were searched until December 30, 2023, for observational studies on PNPLA3 genotyped adults with MASLD. Proportions were pooled using a generalized linear mixed model with Clopper-Pearson intervals. Continuous and dichotomous variables were analyzed using the DerSimonian-Laird method. International Prospective Register of Systematic Reviews registration number: CRD42023449838. Results A total of 109 studies involving 118,302 individuals with MASLD were identified. The overall minor allele frequency of the G allele [MAF(G)] at PNPLA3 was 0.45 (95% confidence interval [CI]: 0.43; 0.48) with high heterogeneity (I2 = 98%). The highest MAF(G) was found in Latin America (0.63) and the lowest in Europe (0.38). No African countries were identified. Carriers of the PNPLA3 variant had reduced adiposity, altered fat metabolism, and worse liver damage/histology than noncarriers. There was significant heterogeneity in the clinical/histological analyses (I2 > 50%). Only the PNPLA3 GG genotype was associated with higher mortality and liver-related events with no heterogeneity (I2 = 0%). Metaregressions showed the influence of adiposity, age, diabetes mellitus, and glucose on some PNPLA3 expression parameters. Overall, there was a moderate risk of bias in the included studies. Conclusions This study reveals the global pattern of PNPLA3 and its clinical, histological, and outcome implications in MASLD. Patients with MASLD and PNPLA3 variant have different clinical features and worse liver severity, and only PNPLA3 GG has a higher risk of mortality and liver outcomes. Our findings highlight the importance of PNPLA3 genotyping in clinical trials and advocate for personalized medicine approaches.
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Affiliation(s)
- Matheus Souza
- Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
| | | | - Ivanna Diaz
- Department of Internal Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, United States
| | - Alessandro Mantovani
- Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
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Errazuriz A, Avello-Vega D, Passi-Solar A, Torres R, Bacigalupo F, Crossley NA, Undurraga EA, Jones PB. Prevalence of anxiety disorders in Latin America: a systematic review and meta-analysis. LANCET REGIONAL HEALTH. AMERICAS 2025; 45:101057. [PMID: 40225404 PMCID: PMC11986631 DOI: 10.1016/j.lana.2025.101057] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 08/26/2024] [Revised: 03/01/2025] [Accepted: 03/04/2025] [Indexed: 04/15/2025]
Abstract
Background The prevalence of anxiety disorders among the adult population in Latin America (LATAM) and its association with development indicators is insufficiently characterised. We estimated pooled regional, country, and sex-specific prevalence rates of anxiety disorders in LATAM based on International Classification of Diseases (ICD) or Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria. Additionally, we examined the association between its prevalence and four country-level development indicators: Human Development Index (HDI), income inequality (Gini coefficient), Gender Inequality Index (GII), and Intentional Homicide Rate (IHR). Methods We conducted a systematic review and meta-analysis of population-based studies on the prevalence of ICD/DSM anxiety disorders in LATAM from 1990 to 2024, irrespective of language. We searched PubMed, PsycINFO, Cochrane Library, SciELO, LILACS, and grey literature. Study quality was assessed using JBI's critical appraisal tools. Pooled estimates were generated using random-effects meta-analysis, and heterogeneity was evaluated using the I-squared (I 2) statistic. Meta-regression analyses were performed to examine the ecological association between anxiety disorders prevalence and four development indicators. The study was registered with PROSPERO (CRD42020190238). Findings Using data from 36 studies in LATAM, we calculated the lifetime, 12-month, and current prevalence of ICD/DSM anxiety disorders at 14.55% (95% Confidence Interval 12.32%-17.11%; I 2 = 97.9%); 6.61% (5.20-8.37; I 2 = 98.1%), and 3.27% (2.34-4.56; I 2 = 97.5%), respectively. Heterogeneity was high across prevalence periods, sexes, and countries (all I 2 ≥ 91.4%), warranting caution in interpreting pooled estimates. Elevated 12-month and current prevalence rates of anxiety disorders were associated with higher Gini coefficients (p ≤ 0.0013). Additionally, higher current prevalence was associated with lower HDI (p = 0.0103) and higher GII (p = 0.0023), while elevated 12-month prevalence was associated with higher IHR (p = 0.011). Interpretation This study shows that approximately one in seven people in LATAM experience anxiety disorders at some point in their lives. These findings highlight the need to strengthen mental health systems in the region, and evidence the association between prevalence of anxiety disorders and development indicators. Our results can serve as a baseline for tracking anxiety disorders and for informed decision-making at the national and regional levels. The substantial heterogeneity between studies and the underrepresentation of some countries underscore the imperative for enhancing regional mental health capacities. Funding Pfizer Independent Medical Education Grant (69879319).
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Affiliation(s)
- Antonia Errazuriz
- Department of Psychiatry, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
| | - Dalia Avello-Vega
- School of Social and Political Science, University of Edinburgh, United Kingdom
| | - Alvaro Passi-Solar
- School of Public Health, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
| | - Rafael Torres
- Department of Psychiatry, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
| | - Felix Bacigalupo
- Department of Psychiatry, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
- School of Psychology, Faculty of Social Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
| | - Nicolas A. Crossley
- Department of Psychiatry, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
| | - Eduardo A. Undurraga
- School of Government, Pontificia Universidad Católica de Chile, Santiago, Chile
- Research Center for Integrated Disaster Risk Management (CIGIDEN), Santiago, Chile
| | - Peter B. Jones
- Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
- NIHR Applied Research Collaboration East of England, CPFT, Cambridge, United Kingdom
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Vizán-Chaguaceda R, Leirós-Rodríguez R, Hernandez-Lucas P. Efficacy of Fractionated Carbon Dioxide Laser for the Treatment of Genitourinary Syndrome of Menopause: A Systematic Review and Meta-analysis. Obstet Gynecol 2025; 145:475-485. [PMID: 40112298 DOI: 10.1097/aog.0000000000005885] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/12/2024] [Accepted: 01/09/2025] [Indexed: 03/22/2025]
Abstract
OBJECTIVE To evaluate the short-term effectiveness of fractional CO 2 laser for the treatment of genitourinary syndrome of menopause. DATA SOURCES Systematic review was performed of PubMed, Scopus, Web of Science, Cinhal, MEDLINE, and ClinicalTrials.gov . METHODS OF STUDY SELECTION The included studies had to meet the following criteria: 1) The sample consisted exclusively of women diagnosed with genitourinary syndrome of menopause; 2) at least one group in the sample underwent treatment with fractional CO 2 laser; 3) the control group received simulated fractional CO 2 laser therapy, topical hormonal treatment, or a topical gel lubricant; 4) the studies evaluated outcomes related to sexual function, urinary symptoms, or the quality of the vaginal epithelium; and 5) the study design was a randomized controlled trial. The exclusion criterion specified that participants should not have a history of any type of cancer or prior treatment with a different type of laser. TABULATION, INTEGRATION, AND RESULTS Two reviewers independently screened articles for eligibility and extracted data. Difference in mean differences and their 95% CIs were calculated as the between-group difference in means divided by the pooled SD. The I2 statistic was used to determine the degree of heterogeneity. The 11 articles included in the review had a group receiving fractional CO 2 laser therapy and a control group receiving simulated fractional CO 2 laser, topical hormonal treatment, or topical gel lubricant. The meta-analyses indicated that fractional CO 2 laser is effective for improving sexual function through increased sexual desire, arousal, lubrication, orgasms, and sexual satisfaction; reducing pain during sexual activity (standardized mean difference 0.51, P =.021); and improving urinary function by reducing the frequency and magnitude of urinary leakage and frequency of urination (standardized mean difference 0.51, P <.001). CONCLUSION Fractional CO 2 laser is associated with statistically significant improvements in the short-term treatment of sexual and urinary symptoms but not vaginal epithelium quality. The clinical significance of these changes is unclear. SYSTEMATIC REVIEW REGISTRATION PROSPERO, CRD42023435636.
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Affiliation(s)
- Raquel Vizán-Chaguaceda
- Nursing and Physical Therapy Department and the SALBIS Research Group, University of León, Ponferrada, and the Faculty of Physiotherapy, University of Vigo, Pontevedra, Spain
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Tsai TC, Song J, Chi KY, Lin HM, Chang Y. Comparative survival outcome of synchronous and metachronous brain metastasis from colorectal cancer: A meta‑analysis. Oncol Lett 2025; 29:233. [PMID: 40144803 PMCID: PMC11938025 DOI: 10.3892/ol.2025.14979] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/17/2025] [Accepted: 02/21/2025] [Indexed: 03/28/2025] Open
Abstract
Synchronous and metachronous brain metastases (BM) are increasingly recognized in patients with colorectal cancer (CRC). This study aimed to assess whether the timing of BM development affects survival outcomes by conducting a systematic review and meta-analysis. A comprehensive search of the Cochrane Library, Embase and MEDLINE databases was performed, covering studies from January 1900 to December 2023. To compare survival outcomes between synchronous and metachronous BM, hazard ratios (HRs) for overall survival (OS) were extracted from the included studies and pooled using a random-effects model. The systematic review included nine retrospective cohort studies comprising 910 patients with BM from CRC. Meta-analysis results showed no significant difference in OS between patients with synchronous and metachronous BM (HR, 0.90; 95% confidence interval, 0.59-1.38; P=0.63). In conclusion, this meta-analysis suggests that the timing of BM development does not impact OS in patients with BM from CRC.
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Affiliation(s)
- Tsung-Chiao Tsai
- Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C
| | - Junmin Song
- Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York City, NY 10461, USA
| | - Kuan-Yu Chi
- Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York City, NY 10461, USA
| | - Hong-Min Lin
- Department of Family Medicine, Chi-Mei Medical Center, Tainan 710, Taiwan, R.O.C
| | - Yu Chang
- Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan, R.O.C
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Esteves-Oliveira M, Schaffrath K, Wierichs RJ. Efficacy of laser-assisted caries removal and hard tissue preparation: A meta-analysis. J Dent 2025; 156:105697. [PMID: 40120794 DOI: 10.1016/j.jdent.2025.105697] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/15/2025] [Revised: 03/14/2025] [Accepted: 03/15/2025] [Indexed: 03/25/2025] Open
Abstract
INTRODUCTION/OBJECTIVES The meta-analysis systematically explored clinical studies investigating caries excavation with a laser. DATA Prospective controlled (non-)randomized clinical trials comparing caries excavation using a laser to using conventional burs. SOURCES Four electronic databases (Central Cochrane, PubMed-Medline, Ovid-EMBASE, Web of science) were screened. Outcomes were e.g. restoration survival, excavation speed, pulp sensitivity/vitality, need of anesthesia, pain sensation. No time restrictions were applied. Risk of Bias and level of evidence was graded using Risk of Bias 2.0 tool and Grade Profiler. STUDY SELECTION/RESULTS Twenty in vivo studies with at least 2263 teeth being assessed in more than 1090 patients were included. Meta-analysis for comparing laser vs. bur revealed that restoration survival (risk ratio (RR)[95%CI]=1.51 [0.87;2.64, low level of evidence) and pulp vitality (RR[95%CI]=1.46 [0.33;6.46], low level of evidence) was not significantly influenced by the use of a laser. Furthermore, significantly fewer patients required anesthesia (RR[95%CI]=0.29 [0.11;0.75, very low level of evidence) and patients' pain sensation was significantly decreased (RR[95%CI]=0.35 [0.22;0.54], very low level of evidence) when a laser was used for excavation and preparation. In contrast, when using a laser for excavation/preparation significantly more time has to be planed compared to the use of a conventional bur (mean difference [95%CI]=2.23 [1.89;2.57], low level of evidence). CONCLUSION Using a laser for excavation/preparation treatment does not affect restoration survival and pulp vitality compared to the use of conventional burs, while the need of anesthesia and patients' pain sensation can be reduced. However, significantly more time must be spent to achieve these benefits. CLINICAL SIGNIFICANCE Laser-assisted caries removal reduces the need for anesthesia and minimizes patient discomfort compared to conventional rotary instruments, while restoration survival and pulp vitality are not affected. However, excavation speed remains significantly slower. Furthermore, results should be interpreted with caution considering the low level of the evidence.
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Affiliation(s)
- Marcella Esteves-Oliveira
- Department of Conservative Dentistry, Periodontology and Endodontology, Oral Medicine and Maxillofacial Surgery, University Centre of Dentistry, Oral Medicine and Maxillofacial Surgery (UK-ZMK), Faculty of Medicine of the University of Tübingen, Germany
| | - Katharina Schaffrath
- Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Aachen, Germany
| | - Richard Johannes Wierichs
- Department of Restorative, Preventive and Pediatric Dentistry, School of Dental Medicine, University of Bern, Switzerland; Unit for Practice-based Research, School of Dental Medicine, University of Bern, Switzerland.
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Prentice F, Chehabeddine L, Eriksson MH, Murphy J, Sepeta LN, Gaillard WD, Berl MM, Liégeois F, Baldeweg T. Is an earlier onset of focal epilepsy associated with atypical language lateralization? A systematic review, meta-analysis and new data. Neurosci Biobehav Rev 2025; 172:106110. [PMID: 40132755 DOI: 10.1016/j.neubiorev.2025.106110] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/13/2024] [Revised: 01/18/2025] [Accepted: 03/14/2025] [Indexed: 03/27/2025]
Abstract
Right and bilateral language representation is common in focal epilepsy, possibly reflecting the influence of epileptogenic lesions and/or seizure activity in the left hemisphere. Atypical language lateralization is assumed to be more likely in cases of early seizure onset, due to greater language plasticity in childhood. However, evidence for this association is mixed, with most research based on small samples and heterogenous cohorts. In this preregistered meta-analysis we examined the association between age at seizure onset and fMRI-derived language lateralization in individuals with focal epilepsy. The pooled effect size demonstrated a correlation between an earlier onset and rightward language lateralization in the total sample (r = 0.1, p = .005, k = 58, n = 1240), with no difference in the correlation between age at seizure onset and language lateralization between left and right hemisphere epilepsy samples (Q=62.03, p = .302). In exploratory analyses of the individual participant data (n = 1157), we demonstrated strong evidence that a logarithmic model fits the data better than a linear (BF=350) or categorical model with 6 years of age as a cut-off (BF=36). These findings indicate that there is a small but significant relationship between age at seizure onset and language lateralization. The relationship was consistent with theories of language plasticity proposing an exponential decline in plasticity over early childhood. However, given that this effect was subtle and only found in larger sample sizes, an early age at seizure onset would not serve as a good indicator of atypical language lateralization on the individual patient level.
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Affiliation(s)
- Freya Prentice
- Developmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Neuropsychology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA.
| | - Lara Chehabeddine
- Developmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Clinical Research Institute, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
| | - Maria Helena Eriksson
- Developmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Neuropsychology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK; Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, Canada; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
| | - Jennifer Murphy
- School of Psychology, University of Surrey, Guildford, UK; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
| | - Leigh N Sepeta
- Center for Neuroscience Research, Children's National Hospital, George Washington University, Washington, DC, USA; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
| | - William D Gaillard
- Center for Neuroscience Research, Children's National Hospital, George Washington University, Washington, DC, USA; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
| | - Madison M Berl
- Center for Neuroscience Research, Children's National Hospital, George Washington University, Washington, DC, USA; Division of Neuropsychology, Children's National Hospital, Washington, DC, USA; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
| | - Frédérique Liégeois
- Developmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
| | - Torsten Baldeweg
- Developmental Neurosciences Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Neuropsychology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK; Departments of Psychiatry and Behavioral Sciences, George Washington University, Washington, DC, USA
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Meier M, Jansen K, Vertgewall H, Claes L. The Lifetime Prevalence of Non-Suicidal Self-Injury in Children and Adolescents With Eating Disorders-A Systematic Review and Meta-Analysis. EUROPEAN EATING DISORDERS REVIEW 2025; 33:511-524. [PMID: 39614701 PMCID: PMC11965553 DOI: 10.1002/erv.3158] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/27/2024] [Revised: 10/09/2024] [Accepted: 11/09/2024] [Indexed: 12/01/2024]
Abstract
OBJECTIVE Eating disorders (EDs) and non-suicidal self-injury (NSSI) are both phenomena with onset in adolescence. Their co-occurrence is associated with higher symptom severity and an elevated risk of suicide. In this meta-analysis, we examine the lifetime prevalence of NSSI in youth with EDs. METHODS We searched PsycInfo, PubMed and previously published systematic reviews for studies reporting on lifetime NSSI prevalence among children and adolescents (19 years or younger) with an ED (anorexia nervosa, bulimia nervosa, binge eating or other specified feeding and EDs) published until June 2024. A generalized linear mixed model meta-analysis was performed to estimate the pooled prevalence. Meta-regressions and multivariate meta-analyses were conducted to estimate separate prevalence rates based on ED diagnosis and care frame (e.g., inpatient vs. outpatient), respectively. RESULTS Fifteen studies comprising 3311 children and adolescents were included. Pooled lifetime NSSI prevalence across all ED diagnoses was 34.2% [CI: 27.5%-41.7%]. Heterogeneity was large (I2 = 93.8%). Lifetime NSSI prevalence rates were significantly higher for participants with bulimia nervosa (53.6%) and those with anorexia nervosa binge-eating/purging type (51.9%) than for participants with anorexia nervosa restrictive type (15.8%). DISCUSSION The small number of studies and the large heterogeneity limit the conclusiveness of this meta-analysis. Results suggest an even higher prevalence of lifetime NSSI in adolescents with an ED than in adults with an ED. The results support previous findings indicating higher prevalence rates of NSSI for EDs associated with binge eating and purging behaviours than for restrictive EDs.
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Affiliation(s)
- Marieke Meier
- Institute of PsychologyUniversity of MuensterMuensterGermany
| | - Katrin Jansen
- Institute of PsychologyUniversity of MuensterMuensterGermany
| | | | - Laurence Claes
- Faculty of Psychology and Educational SciencesKU LeuvenLeuvenBelgium
- Faculty of Medicine and Health Sciences (CAPRI)University of AntwerpAntwerpBelgium
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Kim R, Kang N, Lee JH, Lee H, Lee TL, Ko DK, Lee H, Byun K, Park K, Lee JY, Jeon B. Moderators of aerobic exercise effects on motor symptoms in patients with Parkinson's disease: A systematic review and meta-analysis. Parkinsonism Relat Disord 2025; 134:107779. [PMID: 40107946 DOI: 10.1016/j.parkreldis.2025.107779] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/12/2024] [Revised: 03/08/2025] [Accepted: 03/09/2025] [Indexed: 03/22/2025]
Abstract
INTRODUCTION Although growing evidence suggests that aerobic exercise has beneficial effects on motor symptoms in patients with Parkinson's disease (PD), it remains unclear which specific aerobic exercise regimen optimizes improvement in these symptoms. This study aimed to investigate the difference in the effects of aerobic exercise on motor function in patients with PD according to exercise intervention protocols. METHODS Through 28 qualified studies with randomized controlled trials, we assessed motor function using either the Unified PD Rating Scale (UPDRS) III or Movement Disorder Society-UPDRS III as an outcome measure. We employed random effects meta-analysis models to obtain standardized mean differences and 95 % confidence intervals (CIs). Moderator variable analyses were conducted based on exercise type (aerobic exercise vs. aerobic-based combined exercise), duration (<60 min vs. ≥60 min per session), frequency ( RESULTS Aerobic exercise interventions demonstrated significant improvements in overall motor function. Although all categories were significantly effective in improving motor function, aerobic-based combined exercise had a greater effect size on motor symptoms compared to aerobic exercise alone. Additionally, ≥60 min per session showed a significantly increased effect size compared to <60 min per session. The impact of aerobic exercise did not differ based on exercise frequency, period, or intensity. CONCLUSIONS Our observations suggest that aerobic-based combined exercise and exercise sessions lasting 60 min or longer may be associated with greater improvements in motor symptoms in patients with PD.
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Affiliation(s)
- Ryul Kim
- Department of Neurology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.
| | - Nyeonju Kang
- Division of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Incheon, South Korea; Department of Human Movement Science, Incheon National University, Incheon, South Korea; Neuromechanical Rehabilitation Research Laboratory, Incheon National University, Incheon, South Korea.
| | - Joon Ho Lee
- Division of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Incheon, South Korea; Department of Human Movement Science, Incheon National University, Incheon, South Korea
| | - Hanall Lee
- Division of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Incheon, South Korea; Department of Human Movement Science, Incheon National University, Incheon, South Korea
| | - Tae Lee Lee
- Division of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Incheon, South Korea; Department of Human Movement Science, Incheon National University, Incheon, South Korea
| | - Do Kyung Ko
- Division of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Incheon, South Korea; Department of Human Movement Science, Incheon National University, Incheon, South Korea
| | - Hajun Lee
- Division of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Incheon, South Korea; Department of Human Movement Science, Incheon National University, Incheon, South Korea
| | - Kyeongho Byun
- Division of Sport Science, Sport Science Institute & Health Promotion Center, Incheon National University, Incheon, South Korea
| | - Kiwon Park
- Department of Mechatronics Engineering, Incheon National University, Incheon, South Korea
| | - Jee-Young Lee
- Department of Neurology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea
| | - Beomseok Jeon
- Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea
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Jin L, Li P, Xu Q, Wang F, Zhang L. Association of net ultrafiltration intensity and clinical outcomes among critically ill patients receiving continuous renal replacement therapy: A systematic review, meta-analysis, and trial sequential analysis. Aust Crit Care 2025; 38:101170. [PMID: 39889501 DOI: 10.1016/j.aucc.2024.101170] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/09/2024] [Revised: 12/30/2024] [Accepted: 12/30/2024] [Indexed: 02/03/2025] Open
Abstract
BACKGROUND Net ultrafiltration (UFnet) has been used in the fluid management of critically ill patients undergoing continuous renal replacement therapy for an extended duration. Despite its widespread application, the correlation between UFnet intensity and clinical outcomes remains controversial. METHODS Electronic databases (PubMed, Embase, Web of Science, and the Cochrane database) were searched from inception to November 30, 2023. All possible studies that examined the following outcomes were included: all-cause mortality, recovery of kidney function, and length of hospital stay. RESULTS A total of 6209 patients from six cohort studies were included. There was no significant association observed between UFnet intensity and either mortality (odds ratio [OR] = 0.90, 95% confidence interval [CI] = 0.68-1.21, p = 0.49, I2 = 84%) or renal recovery (OR = 0.96, 95% CI = 0.57-1.61, p = 0.87, I2 = 75%) among critically ill patients. However, a high intensity of UFnet was associated with lower mortality in patients with acute kidney injury (AKI) (OR = 0.73, 95% CI = 0.59-0.90, p = 0.004, I2 = 67%). Furthermore, the study revealed a noteworthy correlation between a high UFnet intensity and a longer length of hospital stay (weighted mean difference = 3.34 d, 95% CI = 2.64-4.03, p2 = 0%). CONCLUSIONS The association between UFnet intensity and mortality or renal recovery in critically ill patients is insufficient. However, a high UFnet intensity is associated with an increasing length of hospital stay among critically ill patients.
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Affiliation(s)
- Lu Jin
- Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China
| | - Peiyun Li
- Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China
| | - Qing Xu
- Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China
| | - Fang Wang
- Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China
| | - Ling Zhang
- Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.
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Zhao X, Sun J, Huang D. Meta-analysis application to hERG safety evaluation in clinical trials. J Biopharm Stat 2025; 35:343-355. [PMID: 38875133 DOI: 10.1080/10543406.2024.2365972] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/21/2023] [Accepted: 06/05/2024] [Indexed: 06/16/2024]
Abstract
One objective of meta-analysis, which synthesizes evidence across multiple studies, is to assess the consistency and investigate the heterogeneity across studies. In this project, we performed a meta-analysis on moxifloxacin (positive control in QT assessment studies) data to characterize the exposure-response relationship and determine the safety margin associated with 10-msec QTc effects for moxifloxacin based on 26 thorough QT studies submitted to the FDA. Multiple meta-analysis methods were used (including two novel methods) to evaluate the exposure-response relationship and estimate the critical concentration and the corresponding confidence interval of moxifloxacin associated with a 10-msec QTc effect based on the concentration-QTc models. These meta-analysis methods (aggregate data vs. individual participant data; fixed effect vs. random effect) were compared in terms of their precision and robustness. With the selected meta-analysis method, we demonstrated the homogeneity and heterogeneity of the moxifloxacin concentration-QTc relationship in studies. We also estimated the critical concentration of moxifloxacin that can be used to calculate the hERG safety margin of this drug.
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Affiliation(s)
- Xutong Zhao
- Division of Biometrics VI, Office of Biostatistics, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA
| | - Jing Sun
- Division of Biometrics VI, Office of Biostatistics, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA
| | - Dalong Huang
- Division of Biometrics VI, Office of Biostatistics, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA
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Rosen EM, Crawford L, Hoffmann S, Skidmore B, Porter AK, Halperin SA, Longnecker MP. Systematic review and meta-analysis of epidemiologic data on infectious disease in relation to exposure to twelve perfluoroalkyl substances (PFAS). Int J Hyg Environ Health 2025; 266:114571. [PMID: 40184785 DOI: 10.1016/j.ijheh.2025.114571] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2024] [Revised: 02/24/2025] [Accepted: 03/23/2025] [Indexed: 04/07/2025]
Abstract
BACKGROUND While some per- and polyfluoroalkyl substances (PFAS) are immunosuppressants, whether they have an adverse effect on infectious disease morbidity is unclear. We conducted a systematic review and meta-analysis of epidemiologic data on the association between an incremental increase in serum concentration of any of 12 PFAS and the risk or rate of infectious disease (ID). METHODS From 25 reports representing 18 unique study populations, we conducted meta-analyses stratified on exposure type (log-transformed or absolute scale) and outcome type (risk or rate). To synthesize data that could not be combined with meta-analysis due to different exposure or outcome types, we additionally conducted vote counting and calculated combined p-values. RESULTS A small positive association between PFAS exposure and ID risk or rate was more frequently reported than not, though in the synthesized data statistical significance was present only in a few instances. The meta-analyses and combined p-value analyses had many similar findings. In the combined p-value analyses, statistically significant positive associations were noted between Perfluorononanoic acid and lower respiratory tract infection (LRTI) event rates, Perfluorooctanesulfonamide and LRTI event rates and LRTI risk and rates combined, Perfluorooctanoic acid and Perfluorodecanoic acid with all ID risk and rates combined, and Perfluoroundecanoic acid with all ID risk. CONCLUSION We identified moderate evidence of positive associations that were of variable size but usually small; the certainty of evidence was, however, generally low or very low and diminished by the possible influences of multiple testing and covariance among results not accounted for in the analyses. PROSPERO REGISTRATION CRD42024551990.
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Affiliation(s)
- Emma M Rosen
- Ramboll Americas Engineering Solutions, Inc., 101 Carnegie Center Dr #200, Princeton, NJ, 08540, USA.
| | - Lori Crawford
- Ramboll Americas Engineering Solutions, Inc., 28 Amity St., Suite 2A, Amherst, MA, 01002, USA.
| | | | - Becky Skidmore
- Skidmore Research & Information Consulting, Inc., Ottawa, Ontario, Canada.
| | - Anna K Porter
- Yale School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA.
| | - Scott A Halperin
- Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre and Nova Scotia Health Authority, Halifax, Canada; Department of Pediatrics, Dalhousie University and the IWK Health Centre and Nova Scotia Health Authority, Halifax, Canada; Department of Microbiology and Immunology, Dalhousie University and the IWK Health Centre and Nova Scotia Health Authority, Halifax, Canada.
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Lam KKL, Zhou M. A Meta-analysis of the relationship between growth mindset and grit. Acta Psychol (Amst) 2025; 255:104872. [PMID: 40086228 DOI: 10.1016/j.actpsy.2025.104872] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/24/2024] [Revised: 03/01/2025] [Accepted: 03/04/2025] [Indexed: 03/16/2025] Open
Abstract
Growth mindset is one of the popular educational constructs with strong empirical ties to students' motivation and persistence in the academic context, which has been empirically linked to students' grit. Although a growing body of research suggests that growth mindset and grit are related in nuanced ways, a comprehensive and detailed portrait of this connection is needed to better understand how growth mindset is linked to grit. In this study, we systematically reviewed empirical research on growth mindset and grit among student population. Sixty-six eligible studies involving a total of 42,112 participants were examined. Using the robust variance estimation, we found that the correlations of growth mindset with grit/its facets were generally medium to strong (ρoverall grit = 0.19; ρinterest = 0.20; and ρeffort = 0.24, respectively). The p-curve analysis results suggested that cumulative studies contained evidential value (p < .001). We also investigated 11 potential moderators using meta-regression (covering study, participant, and measurement characteristics), and no significant moderators were observed in the associations between growth mindset and either facet of effort. A stronger growth mindset-overall grit association was observed in a collectivistic context. We concluded with a discussion of heterogeneity, limitations, and implications of meta-analyses.
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Affiliation(s)
- Kelly Ka Lai Lam
- Department of Psychology, University of Macau, Macao Special Administrative Region of China; Centre for Cognitive and Brain Sciences, University of Macau, Macao Special Administrative Region of China.
| | - Mingming Zhou
- Faculty of Education, University of Macau, Macao Special Administrative Region of China
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Namsrai T, Northey JM, Ambikairajah A, Ahmed O, Alateeq K, Espinoza Oyarce DA, Burns R, Rattray B, Cherbuin N. Sleep characteristics and brain structure: A systematic review with meta-analysis. Sleep Med 2025; 129:316-329. [PMID: 40086297 DOI: 10.1016/j.sleep.2025.02.028] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/16/2024] [Revised: 02/09/2025] [Accepted: 02/19/2025] [Indexed: 03/16/2025]
Abstract
BACKGROUND As the global population ages, the prevalence of associated conditions, including neurodegeneration and dementia, will increase. Thus, reducing risk factors is crucial to prevention. Sleep contributes to brain homeostasis and repair, which, if impaired, could lead to neurodegeneration. However, the relationship between sleep characteristics, disorders, and brain morphology is poorly understood in healthy adults. Therefore, we aimed to systematically analyse the literature and clarify how sleep characteristics are associated with brain structures. METHODS We systematically searched PUBMED, MEDLINE, ProQuest, Web of Science, and Scopus for empirical studies of healthy adults examining the associations between sleep characteristics or disorders and brain structure, adjusting for age, gender, and head size. We conducted a meta-analysis with random effects models for volumetric studies and a seed-based spatial analysis for voxel-based morphometry (VBM) studies. RESULTS One hundred and five articles (60 volumetric, 45 VBM) with 106 studies reporting 108,364 participants were included. Most studies (73.1%) found sleep characteristics and disorders to be associated with predominantly lower brain volumes (cross-sectional: 51.9% of all cross-sectional; longitudinal: 45.5% of longitudinal). In VBM studies, REM sleep behaviour disorder was linked to lower grey matter volume in the right frontal gyrus (z-score = -3.617, 68 voxels, p-value = <0 0.001). CONCLUSION Sleep characteristics - poor quality, short or long sleep - and sleep disorders are predominantly associated with lower brain volumes, suggesting that inadequate sleep (short, long or poor quality) might contribute to neurodegeneration. This insight highlights the importance of monitoring, managing, and enforcing sleep health to prevent or mitigate potential neurodegenerative processes.
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Affiliation(s)
- Tergel Namsrai
- National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia.
| | - Joseph M Northey
- National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia; Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Canberra, Australia
| | - Ananthan Ambikairajah
- National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia; Discipline of Psychology, Faculty of Health, University of Canberra, Canberra, Australia; Centre for Ageing Research and Translation, Faculty of Health, University of Canberra, Canberra, Australia; The University of Sydney, School of Psychology, Sydney, Australia; The University of Sydney, Brain and Mind Centre, Sydney, Australia
| | - Oli Ahmed
- National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia
| | - Khawlah Alateeq
- National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia; Radiological Science, College of Applied Medical Sciences, King Saud University, Riyadh, 11451, Saudi Arabia
| | | | - Richard Burns
- National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia
| | - Ben Rattray
- Centre for Ageing Research and Translation, Faculty of Health, University of Canberra, Canberra, Australia
| | - Nicolas Cherbuin
- National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia
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Wang XS, Wang Y, Xu Y, Zhang SR, Zhang Y, Peng LL, Wu N, Ye JS. Effectiveness of mesenchymal stem cell-derived extracellular vesicles therapy for Parkinson’s disease: A systematic review of preclinical studies. World J Stem Cells 2025; 17:102421. [DOI: 10.4252/wjsc.v17.i4.102421] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/17/2024] [Revised: 01/23/2025] [Accepted: 03/03/2025] [Indexed: 04/23/2025] Open
Abstract
BACKGROUND Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can traverse the blood-brain barrier due to their small size. This characteristic makes them a research hotspot for the treatment of Parkinson’s disease (PD) and is expected to be a potentially revolutionary strategy for treating PD. Despite this, no summary of clinical trial results has been reported.
AIM To assess the efficacy and durability of MSC-EVs in treating PD.
METHODS Systematic searches were conducted in four electronic databases until June 2024 to collect studies on the use of MSC-EVs for this purpose. Thirteen relevant randomized controlled trials, encompassing 16 experiments, were selected for inclusion.
RESULTS Behavioral assessments, including the rotarod and apomorphine turning behavior tests, indicated improvements in motor coordination (P < 0.00001); the Pole test and the Wire-hang test showed enhanced limb motor agility and synchronization (P = 0.003 and P < 0.00001, respectively). Histopathologically, there was a reduction in inflammatory markers such as tumor necrosis factor-α and interleukin-6 (P = 0.03 and P = 0.01, respectively) and an increase in tyrosine hydroxylase-positive cells in the lesion areas (P < 0.00001).
CONCLUSION MSC-EV therapy for PD is a gradual process, with significant improvements observable more than 2 weeks after administration and lasting at least 8 weeks. This study is the first to demonstrate the efficacy and durability of MSC-EV treatment in PD.
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Affiliation(s)
- Xue-Song Wang
- Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
| | - Yue Wang
- Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- College of Nursing, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
| | - Yan Xu
- Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
| | - Shan-Rong Zhang
- Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- First Clinical Medical College of Gannan Medical University, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
| | - Yang Zhang
- School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
| | - Lu-Lu Peng
- Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- First Clinical Medical College of Gannan Medical University, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
| | - Nan Wu
- First Clinical Medical College of Gannan Medical University, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
| | - Jun-Song Ye
- Subcenter for Stem Cell Clinical Translation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- Jiangxi Provincial Key Laboratory of Tissue Engineering, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
- Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
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Yang HC, Fu CF, Qiao LJ, Long GH, Yang LF, Yao B. Relationship between Helicobacter pylori infection and programmed death-ligand 1 in gastric cancer: A meta-analysis. World J Clin Oncol 2025; 16:102397. [DOI: 10.5306/wjco.v16.i4.102397] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/16/2024] [Revised: 12/04/2024] [Accepted: 02/06/2025] [Indexed: 03/26/2025] Open
Abstract
BACKGROUND Gastric cancer (GC) is one of the most common malignancies worldwide, and Helicobacter pylori (HP) infection is a well-established risk factor for its development. Programmed death-ligand 1 (PD-L1) expression is a crucial biomarker for predicting the efficacy of immune checkpoint inhibitors in cancer treatment. While HP infection and PD-L1 expression in GC may be linked, the relationship between them remains unclear, in part because there have been conflicting results reported from various studies.
AIM To perform a meta-analysis to assess the relationship between HP and PD-L1 expression in patients with GC.
METHODS A systematic literature review was conducted using PubMed, Embase, Cochrane Library, and Web of Science databases. Observational studies that examined the association between HP infection and PD-L1 expression in patients with GC were included. Odds ratios and 95% confidence intervals were calculated to estimate the association. Heterogeneity was assessed using Cochrane’s Q test and I² statistic. A random-effects model was used due to significant heterogeneity across studies.
RESULTS Fourteen studies involving a total of 3069 patients with GC were included. The pooled analysis showed a significant association between HP infection and increased PD-L1 expression in GC tissues (odd ratio = 1.69, 95% confidence interval: 1.24-2.29, P < 0.001, I2 = 59%). Sensitivity analyses confirmed the robustness of these findings. Subgroup analyses did not show significant variation based on geographic region, sample size, or method of PD-L1 assessment. Publication bias was minimal, as shown by funnel plots and Egger’s regression test.
CONCLUSION HP infection is associated with increased PD-L1 expression in GC, suggesting that HP status may influence the response to programmed cell death protein 1/PD-L1 blockade therapy.
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Affiliation(s)
- Hong-Chang Yang
- Department of Gastroenterology, Longgang Central Hospital of Shenzhen, Shenzhen 518100, Guangdong Province, China
| | - Cheng-Feng Fu
- Department of Oncology, Tongren People’s Hospital, Tongren 554300, Guizhou Province, China
| | - Li-Jun Qiao
- Department of Basic Medical Sciences, Guizhou Health Vocational College, Tongren 554300, Guizhou Province, China
| | - Gen-He Long
- Department of School of Medicine, Guizhou Vocational and Technical College, Tongren 554300, Guizhou Province, China
| | - Li-Fen Yang
- Department of Oncology, Tongren People’s Hospital, Tongren 554300, Guizhou Province, China
| | - Biao Yao
- Department of Oncology, Tongren People’s Hospital, Tongren 554300, Guizhou Province, China
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Guo L, Zhang J, An R, Wang W, Fen J, Wu Y, Wang Y. The role of estimated glucose disposal rate in predicting cardiovascular risk among general and diabetes mellitus population: a systematic review and meta-analysis. BMC Med 2025; 23:234. [PMID: 40264086 DOI: 10.1186/s12916-025-04064-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/05/2024] [Accepted: 04/10/2025] [Indexed: 04/24/2025] Open
Abstract
BACKGROUND Estimated glucose disposal rate (eGDR) is a measure of insulin sensitivity. While recent evidence suggests its role in cardiovascular risk assessment in Type 1 diabetes, its associations with cardiovascular disease (CVD), diabetic microvascular complications (DMC), and mortality across different populations remain unclear. METHODS We systematically searched Medline, EMBASE, Web of Science, and the Cochrane Library up to September 1st, 2024, following PRISMA guidelines. We examined associations between eGDR and CVD, DMC (including diabetic retinopathy, nephropathy, and peripheral neuropathy), and all-cause mortality using random-effects models. Secondary analysis assessed mean eGDR levels in diabetes populations. RESULTS Nineteen observational studies (185,810 participants) examined clinical outcomes, while 50 studies reported mean eGDR values. In patients with Type 1 diabetes (T1DM), each 1-unit (mg/kg/min) increase in eGDR was associated with lower risks of CVD (HR 0.78; 95% CI 0.69-0.87; I2 = 68%) and all-cause mortality (HR 0.83; 95% CI 0.79-0.88; I2 = 0%). The association between eGDR and DMC in T1DM was not statistically significant (HR 0.86; 95% CI 0.72-1.03; I2 = 25%). In patients with Type 2 diabetes (T2DM), each 1-unit (mg/kg/min) increase in eGDR was associated with reduced all-cause mortality (HR 0.90; 95% CI 0.84-0.97; I2 = 62%). Similarly, in the general population, each 1-unit (mg/kg/min) increase in eGDR was associated with decreased mortality risk (HR 0.88; 95% CI 0.82-0.94; I2 = 48%). The pooled mean eGDR was higher in patients with T1DM (8.19 mg/kg/min; 95% CI 7.81-8.57; I2 = 99%) compared to those with T2DM (7.03 mg/kg/min; 95% CI 4.89-9.17; I2 = 100%). CONCLUSIONS Higher eGDR levels were consistently associated with lower risks of CVD and mortality in T1DM, with similar associations observed for mortality in T2DM. In the general population, higher eGDR levels were associated with reduced mortality risk. The relationship between eGDR and DMC requires further investigation, particularly in T2DM. These findings suggest eGDR's potential utility as a risk assessment tool, though its clinical application may vary across different populations.
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Affiliation(s)
- Lei Guo
- Department of Neurology, Xindu District People's Hospital of Chengdu, Chengdu, Sichuan, 610500, China
| | - Jun Zhang
- Department of Neurology, Xindu District People's Hospital of Chengdu, Chengdu, Sichuan, 610500, China
| | - Ran An
- School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
| | - Wenrui Wang
- School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
| | - Jie Fen
- Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China
| | - Yanshuang Wu
- Chengdu Xiaojiahe Community Health Center, Chengdu, 610072, China
| | - Yanqing Wang
- School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
- The Second Hospital, Shandong University, Jinan, Shandong, China.
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Wanigasekera LC, Maybery MT, Palermo R, Whitehouse AJO, Tan DW. First Impressions Towards Autistic People: A Systematic Review and Meta-Analysis. Autism Res 2025. [PMID: 40265250 DOI: 10.1002/aur.70019] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/09/2024] [Revised: 02/05/2025] [Accepted: 02/27/2025] [Indexed: 04/24/2025]
Abstract
Emerging evidence suggests that observers tend to form less favorable first impressions toward autistic people than toward non-autistic people. These negative impressions may be associated with immediate behavioral responses, as well as long-lasting attitudes toward those being observed that may negatively impact their psychosocial wellbeing. This systematic review and meta-analysis synthesized the existing literature that has compared first impressions toward autistic and non-autistic people to investigate whether first impressions are influenced by: (1) type of first impression measure, (2) modality of stimulus presentation, and (3) characteristics of the observers and/or stimulus participants. Key inclusion criteria were: (1) one or more groups of observers provided first impression ratings, (2) the stimuli were presented in either audio-only, video-only, audio-video, still image, or speech transcript format, and (3) first impressions toward autistic and non-autistic individuals were compared. A systematic search identified a final sample of 21 articles, which included 221 effects for analyses. Findings showed that first impressions were generally less favorable for autistic compared to non-autistic people across all presentation modalities other than speech transcript, with effect sizes typically moderate to large. Differences in first impressions toward autistic and non-autistic people were generally more pronounced for ratings of interpersonal attraction and social and communication presentation, rather than for ratings of psychological and personality traits. There was also some evidence that characteristics of non-autistic observers, such as autism knowledge and quality of contact with autistic people, impact first impressions. These findings provide insight into the critical role first impressions play in influencing social interaction between autistic and non-autistic individuals.
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Affiliation(s)
| | - Murray T Maybery
- School of Psychological Science, the University of Western Australia, Perth, Australia
| | - Romina Palermo
- School of Psychological Science, the University of Western Australia, Perth, Australia
| | | | - Diana Weiting Tan
- School of Psychological Science, the University of Western Australia, Perth, Australia
- Macquarie School of Education, Macquarie University, Sydney, Australia
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Luo X, Huang Z, Ali K, Hayat K. Evaluating safety and efficacy of plastic versus metal stenting in malignant hilar biliary obstruction: a systematic review and meta-analysis of randomized controlled trials. Postgrad Med J 2025; 101:447-457. [PMID: 39571584 DOI: 10.1093/postmj/qgae165] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/09/2024] [Accepted: 11/07/2024] [Indexed: 04/23/2025]
Abstract
BACKGROUND Stenting malignant hilar biliary obstruction (MHBO) is challenging due to its complex structure, and it is less effective than blockages in the distal bile duct area. Plastic stents (PSs) and metal stents (MSs) are commonly used for stenting MHBO. This study aims to compare the outcomes of PSs and MSs in MHBO patients. METHODS We conducted a search of medical databases up to March 2024. Using a fixed-effect model, we analyzed the risk ratios (RRs) of the outcomes between the PS and MS groups. We calculated the RR for clinical and technical success, reinterventions, and adverse events, as well as the hazard ratio (HR) for survival and stent patency. RESULTS This analysis includes five randomized controlled trials (RCTs) that met the inclusion criteria, comprising a total of 322 patients (156 in the PS group and 166 in the MS group). Significant differences (P < .05) in favor of the MS group were found in the reinterventions (RR 1.80, 95% CI 1.07-3.04), and stent patency (HR 0.54, 95% CI 0.32-0.90). There were no significant differences (P > 0.05) between the PS and MS groups regarding technical success (RR 1.01, 95% CI 0.94-1.09), clinical success (RR 0.86, 95% CI 0.69-1.07), overall survival (HR 0.71, 95% CI 0.47-1.05), stent migration (RR 0.69, 95% CI 0.08-6.02), stent occlusion (RR1.32, 95% CI 0.97-1.81), and adverse events (RR 0.80, 95% CI 0.53-1.20). CONCLUSION Both PS and MS are effective for managing MHBO, while MS offers greater efficacy in increased stent patency and lower reintervention rates. Key message What is already known on this topic Metal stents (MSs) and plastic stents (PSs) are used for palliative treatment of malignant hilar biliary obstruction (MHBO). MSs significantly reduced the need for reinterventions compared to PSs in patients with MHBO. What this study adds There were no significant differences between MSs and PSs in terms of technical success, clinical success, overall survival, stent migration, stent occlusion, or adverse events. How this study might affect research, practice, or policy The study's findings may prompt researchers to design more targeted studies to further investigate these specific outcomes in MHBO patients. The results encourage endoscopists to consider patient-specific factors, such as life expectancy and preference for minimizing recurrent procedures, when choosing between MSs and PSs for MHBO.
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Affiliation(s)
- Xinjie Luo
- Department of surgery, Hangzhou First People's Hospital Tonglu Campus, 311500, Hangzhou, China
| | - Zhicheng Huang
- Department of Intensive Care Unit, Hangzhou Geriatric Hospital, 50 Jingshen Road, 310022, Hangzhou, China
| | - Kamran Ali
- Department of Surgery, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China
| | - Khizar Hayat
- Department of Surgery, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China
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Amlashi MA, Payahoo A, Maskouni SJ, Dehghani E, Talandashti MK, Ghelichi Y, Nikoumanesh M, Rezvani S, Shahinfar H, Shidfar F. Dose-dependent effects of omega-3 polyunsaturated fatty acids on C-reactive protein concentrations in cardiometabolic disorders: a dose-response meta-analysis of randomized clinical trials. Inflammopharmacology 2025:10.1007/s10787-025-01744-8. [PMID: 40263171 DOI: 10.1007/s10787-025-01744-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/28/2025] [Accepted: 03/30/2025] [Indexed: 04/24/2025]
Abstract
BACKGROUND Based on current knowledge, omega-3 fatty acids help to reduce the concentration of C-reactive protein (CRP). However, the dose-response effect and the strength of this effect are not entirely clear. METHODS We systematically searched and screened databases to include eligible studies. This study incorporates a random effect, as well as dose-response meta-analyses using a restricted cubic spline model. RESULTS Forty randomized clinical trials were analyzed. Results demonstrated significant non-linear dose-response efficacy in the reduction of CRP concentration in patients with cardiovascular disease, metabolic syndrome, and hypertension up to 1200 mg/day of EPA and DHA. In addition, there was a linear decrease in CRP concentration in the dyslipidemia population. The meta-analysis results did not show any significant reduction of CRP in overweight and obese participants, and the dose-response analysis failed to show any apparent reduction. In type 2 diabetes, pooling the results revealed a significant reduction in CRP; however, the combination of EPA and DHA failed to show significant dose-response efficacy in changing CRP concentration. CONCLUSION 1200 mg/day of EPA and DHA may help to reduce CRP concentration in patients with cardiometabolic disorders. This reduction is clinically significant, and thus intervention with omega-3 fatty acids should be considered for this population.
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Affiliation(s)
- Manoochehr Amin Amlashi
- Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
- Nutritional Sciences Research Center, Iran University of Medical Sciences, Tehran, Iran
| | - Atefeh Payahoo
- Faculty of Medicine, Marand Branch, Islamic Azad University, Marand, Iran
| | - Saber Jafari Maskouni
- Department of Nutrition, School of Public Health, Jiroft University of Medical Sciences, Jiroft, Iran
| | - Elaheh Dehghani
- Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
- Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
- Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
| | | | - Yeganeh Ghelichi
- Student Research Committee, Varastegan Institute for Medical Sciences, Mashhad, Iran
| | - Mahya Nikoumanesh
- Student Research Committee, Varastegan Institute for Medical Sciences, Mashhad, Iran
| | - Soroush Rezvani
- Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
| | - Hossein Shahinfar
- Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
| | - Farzad Shidfar
- Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
- Nutritional Sciences Research Center, Iran University of Medical Sciences, Tehran, Iran.
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Luo J, Guo L, Fan J, Chen L, Zhou J. A review and meta-analysis: comparing the efficacy of robot-assisted and open radical cystectomy in elderly bladder cancer patients. J Robot Surg 2025; 19:168. [PMID: 40259111 DOI: 10.1007/s11701-025-02323-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/23/2024] [Accepted: 04/03/2025] [Indexed: 04/23/2025]
Abstract
The focus of this comprehensive review and meta-analysis is to evaluate both the efficacy and safety of robot-assisted radical cystectomy (RARC) versus open radical cystectomy (ORC) in treating bladder cancer among elderly patients. A rigorous review of literature utilized several key databases-Google Scholar, the Cochrane Library, EMBASE, PubMed, and the Web of Science, complete with updates through July 2024. The data were analyzed using Stata 18, employing a random-effects model for the analysis. In this analysis, five studies were analyzed. Initial comparisons revealed that age, body mass index (BMI), and pT3 staging were consistent across both groups, with gender being the only exception showing variation. The results demonstrated that patients undergoing robot-assisted cystectomy had reduced estimated blood loss, decreased duration of hospitalization, and fewer instances of positive surgical margins. The analysis found no notable statistical discrepancies in operative durations between the two groups, transfusion rate, overall complications, minor complications, major complications, or lymph node positivity rates. In terms of urinary diversion, ileal conduit was more common in the RARC group, while ureterocutaneostomy was more frequently observed in the ORC group. However, no significant differences were found between the two groups regarding the use of orthotopic neobladder. RARC offers a viable and secure approach for surgical treatment in elderly patients with bladder cancer, showing potential enhancements in crucial areas such as reduced estimated blood loss and shorter durations of hospitalization.
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Affiliation(s)
- Jin Luo
- Department of Urology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China
- Hubei University of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China
| | - Lang Guo
- Department of Urology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China
- Hubei University of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China
| | - Jie Fan
- Department of Urology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China
- Hubei University of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China
| | - Li Chen
- Department of Urology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China
- Hubei University of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China
| | - Jie Zhou
- Department of Urology, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China.
- Hubei University of Traditional Chinese Medicine, Wuhan, 430061, Hubei, People's Republic of China.
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48
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Alcan E, Gessner J, Stangier G, Benke C, Busin J, Christiansen H, Melzig CA. The Association Between Parent-to-Child Fear Learning Pathways and Anxiety Sensitivity: A Systematic Review and Meta-analysis. Clin Child Fam Psychol Rev 2025:10.1007/s10567-025-00517-7. [PMID: 40254673 DOI: 10.1007/s10567-025-00517-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 03/23/2025] [Indexed: 04/22/2025]
Abstract
Although anxiety sensitivity (AS), or the fear of anxiety-related symptoms, has been identified as a risk factor for the development of anxiety psychopathology, the pathways through which this fear is learned have not been fully elucidated. In the current review and meta-analysis, we aimed to systematically examine the association between parent-to-child fear learning pathways (vicarious learning, negative information, reinforcement, and punishment) and AS. A comprehensive search of literature was conducted in PsychINFO, PubMed, Embase, and Web of Science databases, using search terms combining categories related to fear learning pathways, anxiety-related symptoms, parents, children, and adolescents. Based on this search strategy, 28 studies were identified as relevant, of which 11 were included in the systematic review and 10 in the meta-analysis. The overall findings indicated that parent-to-child fear learning pathways are significantly associated with AS. The meta-analysis demonstrated a small but significant association between fear learning pathways and AS, although the type of fear learning pathway did not significantly moderate this relationship. However, age emerged as a significant moderator, suggesting a stronger association in children and adolescents compared to adults. Given that these findings are primarily based on cross-sectional studies, this review underscores the need for longitudinal and experimental research to further clarify the role of parent-to-child fear learning pathways in anxiety sensitivity. Additionally, a better understanding of these pathways may help inform existing interventions and fear prevention strategies, such as those aimed at reducing parental modeling of fearful behaviors or promoting positive verbal messages about anxiety symptoms.
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Affiliation(s)
- Ena Alcan
- Department of Clinical Psychology, Experimental Psychopathology, and Psychotherapy, Institute of Psychology, Philipps-University Marburg, Gutenbergstr. 29a, 35037, Marburg, Germany.
- Department of Biological and Clinical Psychology, Trier University, Trier, Germany.
| | - Jana Gessner
- Department of Clinical Psychology, Experimental Psychopathology, and Psychotherapy, Institute of Psychology, Philipps-University Marburg, Gutenbergstr. 29a, 35037, Marburg, Germany
| | - Giulia Stangier
- Department of Clinical Psychology, Experimental Psychopathology, and Psychotherapy, Institute of Psychology, Philipps-University Marburg, Gutenbergstr. 29a, 35037, Marburg, Germany
| | - Christoph Benke
- Department of Clinical Psychology, Experimental Psychopathology, and Psychotherapy, Institute of Psychology, Philipps-University Marburg, Gutenbergstr. 29a, 35037, Marburg, Germany
| | - Jonas Busin
- Department of Clinical Psychology, Experimental Psychopathology, and Psychotherapy, Institute of Psychology, Philipps-University Marburg, Gutenbergstr. 29a, 35037, Marburg, Germany
| | - Hanna Christiansen
- Department of Clinical Child and Adolescent Psychology, Institute of Psychology, Philipps-University Marburg, Marburg, Germany
| | - Christiane A Melzig
- Department of Clinical Psychology, Experimental Psychopathology, and Psychotherapy, Institute of Psychology, Philipps-University Marburg, Gutenbergstr. 29a, 35037, Marburg, Germany
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Affolter J, Mühlhäusser J, Marengo M, Garofalo F, Gass JM, Mongelli F. Costs of robotic and laparoscopic bariatric surgery: a systematic review and meta-analysis. Surg Endosc 2025:10.1007/s00464-025-11744-y. [PMID: 40259090 DOI: 10.1007/s00464-025-11744-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/03/2025] [Accepted: 04/12/2025] [Indexed: 04/23/2025]
Abstract
BACKGROUND Bariatric surgery is currently the most effective approach to addressing severe obesity and reducing related health issues. Laparoscopy remains the standard technique, whereas robotic-assisted surgery is increasingly adopted, although its role in bariatric surgery remains debated. The main criticism concerns its higher costs and the lack of evidence demonstrating improved clinical outcomes compared to other treatment methods. We aimed to compare the costs of robotic-assisted and laparoscopic bariatric surgery through a systematic review and meta-analysis. METHODS Following PRISMA reporting guidelines, a literature search was conducted in PubMed, Cochrane Library, Web of Science, and Google Scholar for studies comparing robotic-assisted and laparoscopic bariatric surgery. The primary outcome was total hospital costs, with bias assessed using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool. Effect sizes were calculated with 95% confidence intervals, and an overall effect was estimated using a random-effects model. RESULTS A total of 14 retrospective studies (293 articles screened) were included, with 1,414,357 patients (112,363 robotic; 1,301,994 laparoscopic). Total hospital costs favored laparoscopic surgery (SMD 0.721, 95%CI: 0.555-0.887, p < 0.001, absolute difference USD 3819). Operating room costs also favored laparoscopy (SMD 1.339, 95%CI 0.202-2.476, p = 0.021, absolute difference: USD 9746). Laparoscopy was associated with shorter operative time, while robotic surgery showed a slight advantage in hospital stay and complication rates. Subgroup and sensitivity analyses were consistent with the main findings. The quality of evidence was rated as low due to potential biases. CONCLUSIONS Our systematic review and meta-analysis provides the most current and robust evidence indicating that the robotic-assisted approach incurs significantly higher costs than the laparoscopic approach in bariatric surgery. This finding remained consistent across the overall analysis as well as in nearly all subgroup and sensitivity analyses. Randomized controlled trials are warranted to accurately evaluate the cost-effectiveness of the robotic approach in both primary and revisional bariatric procedures.
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Affiliation(s)
- Jan Affolter
- Department of Surgery, Luzerner Kantonsspital, 6000, Lucerne, Switzerland
| | - Julia Mühlhäusser
- Department of Surgery, Luzerner Kantonsspital, 6000, Lucerne, Switzerland
| | - Michele Marengo
- Department of Surgery, Ospedale Regionale di Locarno, EOC, 6600, Locarno, Switzerland
| | - Fabio Garofalo
- Department of Surgery, Ospedale Regionale di Lugano, EOC, 6900, Lugano, Switzerland
- Faculty of Medicine, Università della Svizzera Italiana, 6900, Lugano, Switzerland
| | - Jörn-Markus Gass
- Department of Surgery, Luzerner Kantonsspital, 6000, Lucerne, Switzerland
- Department of Health Sciences and Medicine, University of Lucerne, 6000 Lucerne, Switzerland
| | - Francesco Mongelli
- Faculty of Medicine, Università della Svizzera Italiana, 6900, Lugano, Switzerland.
- Department of Surgery, Ospedale Regionale di Bellinzona e Valli, EOC, via Gallino 12, 6500, Bellinzona, Switzerland.
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50
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Pan Z, Zhang S, Cen S, Hou C, Li M, Ye J, Hu J. The association between allergy and risk of brain tumors: Evidence from 40 observational studies. Acta Neurochir (Wien) 2025; 167:111. [PMID: 40259050 PMCID: PMC12011909 DOI: 10.1007/s00701-025-06499-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/12/2024] [Accepted: 03/18/2025] [Indexed: 04/23/2025]
Abstract
PURPOSE The potential association between the medical history of allergic conditions and brain tumors have been investigated. However, the agreement has not been reached. The aim of this meta-analysis was to explore the possible association between allergic disease and brain tumor risk. METHODS A comprehensive search was conducted and eligible studies were identified. Random-effects model was applied to meta-analyze the data. RESULTS In accordance with the retrieval strategy, 40 articles with 31 case-control studies and 9 cohort studies were enrolled in the present meta-analysis. The results suggested that history of allergy was associated with a decreased risk of brain tumor (OR 0.78, 95% CI 0.71-0.86). Compared to individuals with 1 allergic condition (OR 0.78, 95% CI 0.71-0.85), those with at least 2 allergic conditions (OR 0.65, 95% CI 0.58-0.73) may have a potentially lower brain tumor risk. Moreover, decreased brain tumor risk was found in both adults (OR 0.75, 95% CI 0.69-0.81) and children/adolescents (OR 0.78, 95% CI 0.62-0.97). Allergy history is associated with a decreased risk of glioma (OR 0.71. 95% CI 0.61-0.81). Besides, glioma risk is negatively associated with asthma (OR 0.82, 95% CI 0.74-0.91) and eczema (OR 0.84, 95% CI 0.72-0.98). There is a tendency that allergy is associated with decreased risk of meningioma (OR 0.89, 95% CI 0.74-1.07). CONCLUSIONS Allergy should be considered as a protective factor for brain tumors, especially glioma. Further prospective cohort studies are needed to provide a higher level of evidence.
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Affiliation(s)
- Zhihua Pan
- Department of Medical Oncology, The First People's Hospital of Foshan, Foshan, 518100, People's Republic of China
| | - Senxin Zhang
- Department of Neurosurgery, Shenzhen People's Hospital (The First Affiliated Hospital of Southern University of Science and Technology; The Second Clinical Medical College of Jinan University; Guangdong Engineering Technological Research Center for nervous anatomy and Related Clinical Applications), 518020, Shenzhen, People's Republic of China
| | - Siyi Cen
- School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, People's Republic of China
| | - Chongxian Hou
- Department of Neurosurgery, Shenzhen People's Hospital (The First Affiliated Hospital of Southern University of Science and Technology; The Second Clinical Medical College of Jinan University; Guangdong Engineering Technological Research Center for nervous anatomy and Related Clinical Applications), 518020, Shenzhen, People's Republic of China
| | - Maoxiang Li
- Department of Neurosurgery, Shenzhen People's Hospital (The First Affiliated Hospital of Southern University of Science and Technology; The Second Clinical Medical College of Jinan University; Guangdong Engineering Technological Research Center for nervous anatomy and Related Clinical Applications), 518020, Shenzhen, People's Republic of China.
| | - Jing'an Ye
- Department of Neurosurgery, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, 523059, Guangdong Province, People's Republic of China.
| | - Jiliang Hu
- Department of Neurosurgery, Shenzhen People's Hospital (The First Affiliated Hospital of Southern University of Science and Technology; The Second Clinical Medical College of Jinan University; Guangdong Engineering Technological Research Center for nervous anatomy and Related Clinical Applications), 518020, Shenzhen, People's Republic of China.
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