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Copyright ©The Author(s) 2017.
World J Gastrointest Oncol. Jul 15, 2017; 9(7): 293-299
Published online Jul 15, 2017. doi: 10.4251/wjgo.v9.i7.293
Table 1 Tumor-infiltrating lymphocytes associated with the prognosis of gastric cancer
Ref.Sample sizePatient groupLocationCriteria (cut-off)Prognostic role
Kang et al[15]120EBVaGCStromalHigh infiltrationDecreased DFS and RFS
Grogg et al[16]110GIntratumoralHigh infiltrationIncreased CSS
Lee et al[17]220GIntratumoralHigh densityIncreased OS
Table 2 Lymphocyte subtypes associated with the prognosis of gastric cancer
Ref.Lymphocyte subtypesSample sizePatient groupCriteria (cut-off)Prognostic role
Lee et al[17]CD3+, CD8+, CD45RO+220GHigh densityIncreased OS
Thompson et al[18]CD8+43G/GEJHigh densityDecreased PFS and OS
Kawazoe et al[33]CD8+487GHigh densityIncreased OS
Wakatsuki et al[30]CD45RO+101GHigh numbersIncreased PFS and OS
Chiaravalli et al[34]CD3+, CD8+96MSI-H GHigh numbersIncreased OS
Kim et al[22]CD8+, FOXP3+99MSI-H GHigh densityIncreased OS
Liu et al[23]CD8+/FOXP3+ ratio166GHigh ratioIncreased OS
Shen et al[26]FOXP3+/CD8+ ratio133GHigh ratioDecreased OS
Wang et al[5]FOXP3+107GHigh expressionIncreased OS
Haas et al[20]FOXP3+52GHigh numbersIncreased OS
Mizukami et al[24]FOXP3+120GDiffuse patternDecreased OS
Perrone et al[25]FOXP3+110GHigh numbersDecreased RFS and OS
Zhou et al[27]FOXP3+133GHigh numbersDecreased OS
Choi et al[19]FOXP3+/CD4+ ratio28GHigh ratioIncreased OS
Kim et al[21]FOXP3+/CD4+ ratio180GHigh ratioDecreased OS
Dong et al[35]CD20+100GHigh densityIncreased OS
Ishigami et al[31]NK cells146GHigh numbersIncreased OS
Rosso et al[36]NK cells72GHigh concentrationIncreased DFS and OS
Ishigami et al[37]NK cells169GHigh numbersIncreased OS
Ubukata et al[28]Th1/Th2 ratio157GHigh ratio1Increased OS
Liu et al[29]Th22, Th1732GHigh numbers1Decreased OS