Basic Study
Copyright ©The Author(s) 2017.
World J Gastrointest Oncol. May 15, 2017; 9(5): 209-217
Published online May 15, 2017. doi: 10.4251/wjgo.v9.i5.209
Table 1 Comparison of pathological features by CpG island methylator phenotype status
CIMP-HCIMP-ICIMP-LP value
Mean age6669.263.9
Sex
Female51428
Male162671
ypT stage
0 or pCR2216
1317
221020
3112448
4338
ypN stage
0112765
16821
24513
Systemic recurrence
Absent143066
Present5222
Local recurrence
Absent203787
Present026
EMVI
Negative133384
Positive8715CIMP-L vs CIMP-H P = 0.028
KRAS status
Wildtype152073
Mutant62026KRAS Mut + CIMP-I P = 0.01
CRM
Not involved213995
Involved004
RC path score
1 (pCR)0212
26914
3152973
Total214099
Table 2 Tumour regression scores (Royal College Pathologists data set) by extramural vascular invasion status
EMVI+EMVI-P value
RC Path 1 (pCR)0140.039
RC Path 2128
RC Path 32988
Table 3 Multivariable analysis of pathological and molecular variables against overall survival
Wald statisticOR95%CI (lower)95%CI (upper)P value
T stage1.7351.3920.8512.2790.188
N stage0.2680.8570.4791.5350.605
EMVI9.4224.0411.6579.8570.002
CIMP status0.9820.7910.4981.2570.322
KRAS status2.1621.7400.8323.6400.141
Sex0.4390.7640.3441.6950.508
Local recurrence0.8611.7630.5325.8390.353
Systemic recurrence2.1651.7290.8343.5840.141
Tumour regression (pCR)0.0520.7930.1095.7850.819
Involved CRM0.1461.3390.2996.0020.703
Table 4 Binary logistic regression analysis; extramural vascular invasion positivity against overall survival and other pathological, demographic and molecular features
OR95%CI (lower)95%CI (upper)P value
Overall survival0.9360.8930.9810.006
T stage7.7641.74934.4630.007
N stage2.5520.8517.6510.095
Age1.0240.9691.0810.405
Systemic recurrence0.8650.2003.7490.846
Sex0.5640.1192.6680.470
Local recurrence1.8410.19317.5620.596
Involved CRM0.2760.0098.3760.459
KRAS mutation1.5770.3896.3910.524
CIMP-H6.3681.09137.1620.040