Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients

Table 1 Frequency of vascular endothelial growth factor A -1498C>T and vascular endothelial growth factor A -634G>C genetic polymorphisms in blood samples of patients with resected colorectal carcinoma

Polimorphism	Genotype	n (%)
VEGF-A -1498C>T (n = 129)	CC	27 (20.9)
	CT	58 (44.9)
	TT	44 (34.1)
VEGF-A -634G>C (n = 118)	CC	26 (22.0)
	CG	42 (35.6)
	GG	50 (42.4)

VEGF-A: Vascular endothelial growth factor A.

Table 2 TNM staging of colorectal tumors and their respective polymorphisms of vascular endothelial growth factor -634G>C gene (n = 118)

Stage (n)	C/C n (%)	G/C n (%)	G/G n (%)
I + II (55)	10 (18.2)	22 (40.0)	23 (4I.8)
III + IV (63)	16 (25.4)	20 (31.7)	27 (42.9)
Total	26 (22.0)	42 (35.6%)	50 (42.4)
P	-	0.27	0.53
OR (95%CI)	1	0.56 (0.21-1.53)	0.73 (0.27-1.92)

Cox multiple regression test. OR: Odds ratio.

Table 3 TNM staging of colorectal tumors and their respective polymorphisms of vascular endothelial growth factor -1498C>T gene (n = 129)

Stage (n)	C/C n (%)	G/C n (%)	G/G n (%)
I + II (61)	20 (32.8)	9 (14.8)	32 (52.5)
III + IV (68)	24 (35.3)	18 (26.5)	26 (38.2)
Total	26 (22.0)	42 (35.6)	50 (42.4)
P	-	0.31	0.33
OR (95%CI)	1	1.66 (0.61-4.51)	0.67 (0.30-1.48)

Cox multiple regression test. OR: Odds ratio.

Table 4 Univariate analysis of vascular endothelial growth factor A -1498C>T genetic polymorphism and the presence of liver metastasis in patients with resected colorectal carcinoma (n = 129)

	Liver metastasis	Genotype TT n (%)	Genotype CC n (%)	Genotype CT n (%)
	Yes (25)	7 (28.0)	10 (40.0)	8 (32.0)
	No (104)	37 (35.6)	17 (16.3)	50 (48.1)
P		0.34	0.048	0.765
OR (95%CI)		1	0.32 (0.10-0.98)1	1.18 (0.39-3.55)

¹Significant. OR: Odds ratio.

Table 5 Univariate analysis of vascular endothelial growth factor A -1498C>T genetic polymorphism and 5-year survival in patients with resected colorectal carcinoma (n = 129)

Polymorphism	Genotype	n (%)	5-yr survival (%)	P
VEGF-A-1498C>T (n= 129)	CC	27 (20.9)	46.4	0.0321
	CT	58 (44.9)	61.7
	TT	44 (34.1)	67.1

¹Significant Mantel-Cox log-rank test.

Table 6 Multivariate analysis of vascular endothelial growth factor A -1498C>T genetic polymorphism (n = 129) and vascular endothelial growth factor A -634C>G (n = 118) genotypes and 5-year survival in patients with resected colorectal carcinoma

Variables	Category	HR (95%CI)	P
VEGF-A -1498C>T	TT	1 (reference)	-
	CT	2.79 (1.01- 7.66)	0.0471
	CC	4.67 (1.51-14.43)	0.0071
VEGF-A -634C>G	GG	1 (reference)	-
	CG	1.44 (0.58-3.55)	0.433
	CC	3.76 (1.29-10.93)	0.0151

¹Significant Cox multiple regression test.