Mucins in neoplasms of pancreas, ampulla of Vater and biliary system

Table 1 Expression of various glycoforms of mucin 1 in normal pancreatic tissue

Cells/structure	MUC1/CORE	MUC1/DF3	MUC1/MY.1E12	MUC1/HMFG1
Central areas of acini	-/+	-/+	++	++
Intercalated ducts	+	+	+	+
Intralobular ducts	+	+	+	-/+
Interlobular ducts	-	-/+	-/+	-
Main pancreatic ducts	-	-	-	-

MUC: Mucins.

Table 2 Mucins expression in pancreatic neoplasms

	Normal	PanIN			PDCA	IPMN				MCN	ITPN
		PanIN-I	PanIN-II	PanIN-III		Gastric-type		Intestinal-type
						Non-invasive	Invasive	Non-invasive	Invasive
MUC1	2	2	3	4	4	1	4	1	4	CR	4
MUC2	1	1	1	1	1	1	1	4	4	1	1
MUC4	1	2	3	4	4	NA	NA	NA	NA	NA	NA
MUC5AC	1	4	4	4	4	4	4	4	4	CR	1

NA: Non available data; CR: Conflicting results; PanIN: Pancreatic intraepithelial neoplasia; IPMN: Intraductal papillary mucinus neoplasms; MCN: Mucinous cystic neoplasms; ITPN: Intraductal tubulopapillary neoplasms; MUC: Mucins. 1: No expression; 2: Low expression; 3: Moderate expression; 4: High expression.

Table 3 Mucins expression in neoplasms of biliary system

	BilIN			EHBDC	IPNB
	BilIN-I	BilIN-II	BilIN-III		Pancreatobiliary-type		Intestinal-type
					Non-invasive	Invasive	Non-invasive	Invasive
MUC1	2	3	4	4	2	4	1	3
MUC2	1	1	1	3	ΝΑ	4	ΝΑ	3
MUC4	NA	NA	NA	4	ΝΑ	4	ΝΑ	3
MUC5AC	4	4	4	4	4	4	4	4

NA: Non available data; BilIN: Biliary intraepithelial neoplasia; EHBDC: Extrahepatic bile ducts; IPNB: Intraductal papillary neoplasm of the bile ducts; MUC: Mucins. 1: No expression; 2: Low expression; 3: Moderate expression; 4: High expression.

Table 4 Mucins expression in ampulla Vater neoplasms

	Ampulla vater
	Pancreatobiliary-type	Intestinal-type
MUC1	4	4
MUC2	1	4
MUC4	4	4
MUC5AC	4	3

MUC: Mucins. 1: No expression; 2: Low expression; 3: Moderate expression; 4: High expression.