EPH-EPHRIN in human gastrointestinal cancers

Table 1 Somatic mis-sense mutations of erythropoietin-producing hepatoma receptors in colon and stomach (http://www.sanger.ac.uk/genetics/CGP/Studies/, August 30, 2010)

	Amino acid substitutions		Organs
EPHA2	777G>S		Stomach
EPHA3	792S>P	806D>N	Colon
EPHA6	649R>S	813K>N	Stomach
EPHA7	768S>I		Colon
EPHA8	179R>C	873D>N	Colon, Stomach
EPHB1	719I>V	743R>Q	Stomach
EPHB4	889R>W	1030I>M	Colon,Stomach

EPH: Erythropoietin-producing hepatoma.

Table 2 Up and down regulations of erythropoietin-producing hepatoma receptors in human cancers[4]

	Up-regulation		Down-regulation
	Overexpression	Amplification	Promoter methylation	Loss of heterozygosity	Others or unknown
EPHA1	Stomach		Colon	Colon	Colon
EPHA2	Stomach, colon, esophagus			Colon	(Melanoma)
EPHA3			(Lung)
EPHA4	Colon
EPHA5
EPHA6
EPHA7	Stomach, colon		Stomach, colon
EPHA8				Stomach, colon
EPHB1
EPHB2	Stomach, colon	Stomach	Colon	Colon	(Prostate)
EPHB3		Colon
EPHB4		Colon	Colon	Colon
EPHB5
EPHB6	(Neuroblastoma)

No published data in the blanks. Parenthesis indicate non-GI tract cancers. EPH: Erythropoietin-producing hepatoma.

Table 3 Receptors and ligands corresponding

	EFNA1	EFNA2	EFNA3	EFNA4	EFNA5	EFNB1	EFNB2	EFNB3
EPHA1	x
EPHA2	x	x	x	x	x
EPHA3	x	x	x	x	x
EPHA4	x	x	x	x	x		x	x
EPHA5	x	x	x	x	x
EPHA6		x
EPHA7		x			x
EPHA8	x	x	x	x	x
EPHB1						x	x	x
EPHB2						x	x	x
EPHB3						x	x	x
EPHB4						x	x	x
EPHB5
EPHB6						x	x	x

x indicates a known interaction. Each binding constant is shown in the reference Bowden et al[27]. EPH: Erythropoietin-producing hepatoma.