Precision treatment for human epidermal growth factor receptor 2-amplified advanced rectal cancer: A case report

doi:10.4251/wjgo.v17.i4.102690

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Apr 15, 2025 (publication date) through Mar 25, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Gastrointest Oncol. Apr 15, 2025; 17(4): 102690
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.102690

Table 1 Next-generation sequencing panel 639 assay of a patient with advanced rectal cancer

Gene	Outcome	Abundance of mutations/copy number
KRAS	Negative	-
NRAS	Negative	-
BRAF	Negative	-
ERBB2	Amplification	33
APC	Exon16, c4348C>T, p.R1450	15.9%
CDK12	Amplification	7.5
TP53	Exon4, c.325T>A, p.F109I	16.8%
TMB	TMB-L	2.2 mutations/mb
MSI	MSI-L	36.36%

KRAS: Kirsten rat sarcoma viral oncogene homolog; NRAS: Neuroblastoma rat sarcoma viral oncogene homolog; BRAF: v-raf murine sarcoma viral oncogene homolog B; ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; APC: Adenomatous polyposis coli; CDK12: Cyclin-dependent kinase 12; TP53: Tumour protein P53; TMB: Tumour mutational burden; MSI: Microsatellite instability.

Citation: Xiao X, Wang QW, Zhou ZY, Wang LS, Huang P. Precision treatment for human epidermal growth factor receptor 2-amplified advanced rectal cancer: A case report. World J Gastrointest Oncol 2025; 17(4): 102690
URL: https://www.wjgnet.com/1948-5204/full/v17/i4/102690.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i4.102690