Trends in nanomedicine for colorectal cancer treatment: Bibliometric and visualization analysis (2010-2024)

Table 1 Publications screening

No.	Publications	Screen
1	4211	TS = (“colorectal cancer” OR “colorectal carcinoma” OR “colorectal neoplasms” OR “rectum-colon carcinoma” OR “colorectal neoplasm” OR “colorectal carcinomas” OR “colon cancer” OR “rectal cancer”) AND TS = (“nanomaterials” OR “nanomaterial” OR “nanometer material” OR “nanometer materials” OR “nanoparticles” OR “nanomedicine”)
2	3601	Types of publications: (ARTICLES and REVIEW)
3	3598	Languages of publications: (ENGLISH)

Table 2 The top 10 countries with the highest number of published research papers

No.	Country	Np	Np (%)	Nc	Centrality
1	China	1364	37.9	39508	0.11
2	United States	490	13.6	23928	0.35
3	India	440	12.2	11436	0.13
4	Iran	346	9.6	8040	0.13
5	Saudi Arabia	270	7.5	5551	0.13
6	South Korea	206	5.7	6099	0.12
7	Egypt	194	5.4	3609	0.13
8	United Kingdom	118	3.3	4850	0.14
9	Spain	116	3.2	3047	0.16
10	Italy	108	3	2841	0.09

Np: Number of publications; Nc: Number of citations.

Table 3 The top 10 institutions with the highest number of published documents

No.	Institution	Country	Np	Np (%)	Centrality
1	Egyptian Knowledge Bank	Egypt	174	23	0.29
2	Chinese Academy of Sciences	China	144	19	0.54
3	King Saud University	Sandi Arabia	86	11.3	0
4	Sichuan University	China	70	9.2	0.2
5	Mashhad University Medical Science	Iran	56	7.4	0.02
6	Imam Abdulrahman Bin Faisal University	Sandi Arabia	48	6.3	0.14
7	Islamic Azad University	Iran	48	6.3	0.14
8	Fudan University	China	46	6.1	0.05
9	Tabriz University of Medical Science	Iran	45	6	0.05
10	Jilin University	China	41	15.4	0

Np: Number of publications; Nc: Number of citations.

Table 4 The top 10 authors with the highest local impact based on the H-index

Author	H-index	G-index	M-index	Articles	Citations
Li Y	24	41	2.182	46	1714
Zhang Y	22	43	1.833	53	1885
Wang J	18	31	1.200	31	993
Wang Y	18	34	1.286	34	1167
Li J	17	34	1.417	41	1160
Gao Y	16	24	1.231	24	836
Khan FA	16	25	2.286	33	679
Li L	16	29	1.333	36	855
Zhang H	16	27	1.143	30	766
Chen Y	15	24	1.154	35	631

Table 5 Co-cited authors based on centrality

Author	Freq	Total link strength	Centrality	Citations
Zhang Y	259	1222	0.28	299
Wang Y	205	1062	0.2	247
Maeda H	185	1042	0.2	242
Davis ME	63	397	0.16	87
Siegel RL	301	1297	0.14	320
Liu Y	171	938	0.13	201
Arias JL	28	276	0.12	74
Li Y	149	753	0.11	168
Li L	126	675	0.1	151
Jemal A	248	920	0.1	265

Freq: Frequency.

Table 6 Top 10 journals and co-cited journals with the most publications

No.	Journal	Np	IF in 2023	JCR	Co-cited journal	Co-citations	IF in 2023	JCR
1	International Journal of Nanomedicine	127	6.6	Q1	Biomaterials	3867	12.8	Q1
2	International Journal of Biological Macromolecules International Journal of Pharmaceutics	84	7.7	Q1	Acs Nano	2814	15.8	Q1
3	Journal of Controlled Release	84	5.3	Q1	Adv Drug Deliver Rev	2044	15.2	Q1
4	Pharmaceutics	69	10.5	Q1	Cancer Res	2013	15.2	Q1
5	Biomaterials	63	10.9	Q1	Acs Appl Mater Inter	1717	8.3	Q1
6	Acs Applied Materials & Interfaces	62	12.8	Q1	Adv Mater	1668	27.4	Q1
7	Journal of Drug Delivery Science and Technology Scientific Reports	61	8.3	Q1	Angew Chem Int Edit	1500	16.1	Q1
8	Colloids and Surfaces B-Biointerfaces	59	4.5	Q1	Carbohyd Polym	1482	10.7	Q1
9		58	3.8	Q1	Clin Cancer Res	1112	10	Q1
10		57	5.4	Q1	Ca-Cancer J Clin	984	503.1	Q1

Table 7 Paths between citing journals and cited journals

No.	Journal	Cited journal	Path color
1	Molecular/Biology/Immunology	Mathematical/Mathematics/Mechanics	Orange
2	Molecular/Biology/Immunology	Veterinary/Animal/Parasitology	Orange
3	Physics/Materials/Chemistry	Mathematical/Mathematics/Mechanics	Red
4	Physics/Materials/Chemistry	Veterinary/Animal/Parasitology	Red

Table 8 Top 10 co-cited references referring to frequency

Ref.	Year	Journal	Freq	Centrality
Siegel et al[32]	2019	Ca-Cancer J Clin	104	0.29
Sung et al[16]	2021	Ca-Cancer J Clin	81	0.16
Arnold et al[33]	2017	Gut	51	0.2
Dekker et al[34]	2019	Lancet	49	0.24
Rawla et al[35]	2019	Gastroenterol Rev	45	0.04
Shi et al[36]	2017	Nat Rev Cancer	44	0.23
Siegel et al[15]	2017	Ca-Cancer J Clin	43	0.06
Xi et al[37]	2021	Transl Oncol	40	0.06
Xie et al[38]	2020	Signal Transduct Tar	37	0.05
Senapati et al[39]	2018	Signal Transduct Tar	31	0.1

Freq: Frequency.

Table 9 Top 10 keywords based on their occurrences

No.	Keyword	Occurrences	Centrality	Year
1	Nanoparticles	1111	0.05	2010-2024
2	Colorectal cancer	959	0.28	2010-2024
3	Drug delivery	738	0.13	2010-2024
4	Colon cancer	562	0.34	2010-2024
5	Delivery	554	0.55	2010-2024
6	In vitro	500	0.14	2010-2024
7	Cells	356	0.14	2010-2024
8	Therapy	335	0.05	2010-2024
9	Apoptosis	313	0.77	2010-2024
10	Release	265	0.19	2010-2024