Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism

doi:10.4251/wjgo.v17.i3.98844

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Mar 15, 2025; 17(3): 98844
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.98844

Table 1 Primer sequences

Gene name	Primer sequence (5’-3’)	Product length, bp
GPX4	F: CCCAGTGAGGCAAGACCGAAG	118
GPX4	R: GGCTCCTGCTTCCCGAACTG	118
xCT	F: AGGCGGAGGAACAAGCTGAAC	138
xCT	R: TGCGGACCTGAATAACTCGTCTATG	138
PTGS2	F: AATCTGGCTGCGGGAACACAAC	85
PTGS2	R: TGTCTGGAACAACTGCTCATCACC	85
AKR1C3	F: CGAGCGAGGGCGAGGAGAG	102
AKR1C3	R: AGAAGCGGGCGGTGAATTTGTG	102
ACSL4	F: CCAAGTAGACCAACGCCTTCAGAC	154
ACSL4	R: ATGTGTCCTTCGGTCCCAGTCC	154
LPCAT3	F: ACTCTCTCAGGGTCTCTCGTTGC	179
LPCAT3	R: AGAAGGGCTGGAGGACAGTAATGG	179
GAPDH	F: CTGGAGAAACCTGCCAAGTATG	138
GAPDH	R: GGTGGAAGAATGGGAGTTGCT	138

GPX4: Glutathione peroxidase 4; xCT: Cystine glutamate reverse transporter; PTGS2: Prostaglandin endoperoxide synthase 2; AKR1C3: Aldo-keto reductase family 1 member C3; ACSL4: Acyl-coenzyme A synthetase long chain 4; LPCAT3: Lysophosphatidylcholine acyltransferase 3; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.

Citation: Wu L, Chen HY, Zhang JT, Yang RY, Wang ZB, Xue PS, Peng W, Li KX, Gao WH, Zeng PH. Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism. World J Gastrointest Oncol 2025; 17(3): 98844
URL: https://www.wjgnet.com/1948-5204/full/v17/i3/98844.htm
DOI: https://dx.doi.org/10.4251/wjgo.v17.i3.98844