Impact of Linggui Zhugan decoction on microwave ablation outcomes and recurrence in liver cancer

Table 1 Clinical efficacy evaluation of the patients in this study, n (%)

Efficacy	CR	PR	SD	PD	ORR	DCR
Control group (n = 79)	9 (11.39)	24 (30.37)	31 (39.24)	15 (18.98)	33 (41.76)	64 (81.01)
Research group (n = 85)	26 (30.59)	28 (32.94)	22 (25.88)	9 (10.59)	54 (63.53)	76 (89.41)
χ2 value	8.988	0.124	4.638	2.312	7.782	2.312
P value	0.003b	0.725	0.031a	0.128	0.005b	0.128

^aP < 0.05.

^bP < 0.01.

CR: Complete response; PR: Partial response; SD: Stable disease; PD: Progressive disease; ORR: Objective response rate; DCR: Disease control rate.

Table 2 Adverse reactions observed in patients in this study

Statistic	Gastrointestinal reactions	Fever	Ascites	Hepatalgia	Nausea and vomiting	Total incidence
Control group (n = 79)	4	3	5	4	6	22
Research group (n = 85)	2	1	2	3	3	11
χ2 value	0.853	1.182	1.584	0.235	1.305	5.661
P value	0.355	0.276	0.208	0.627	0.253	0.017a

^aP < 0.05.

Table 3 Univariate cox regression analysis

Factor	Beta	SE	P value	HR	Lower	Upper
Treatment plan	0.773	0.226	0.001b	2.165	1.390	3.373
Age	-0.131	0.223	0.558	0.877	0.566	1.359
Sex	0.335	0.262	0.200	1.398	0.837	2.336
BMI	0.111	0.267	0.677	1.118	0.662	1.886
Etiology	-0.321	0.302	0.288	0.725	0.401	1.312
Cirrhosis	1.118	0.313	< 0.001c	3.058	1.656	5.648
Diabetes	-0.315	0.395	0.426	0.730	0.336	1.585
Hypertension	0.236	0.272	0.386	1.266	0.742	2.160
Tumor diameter	0.851	0.313	0.007b	2.342	1.268	4.323
Number of tumors	0.114	0.294	0.698	1.121	0.630	1.992
Child-Pugh score	-0.992	0.254	< 0.001c	0.371	0.225	0.610
Pre-treatment AFP	0.004	0.001	0.001b	1.004	1.002	1.007
Pre-treatment DCP	0.003	0.004	0.496	1.003	0.995	1.010
Pre-treatment AFP-L3	0.005	0.001	< 0.001c	1.005	1.002	1.007
Pre-treatment TBil	0.012	0.011	0.256	1.012	0.991	1.034
Pre-treatment ALT	-0.013	0.012	0.304	0.987	0.963	1.012
Pre-treatment CD4	0.011	0.019	0.545	1.011	0.975	1.049
Pre-treatment CD8	-0.014	0.020	0.479	0.986	0.947	1.026
Pre-treatment CD4/CD8	0.139	0.229	0.544	1.150	0.733	1.802

^bP < 0.01.

^cP < 0.001.

BMI: Body mass index; AFP: Alpha-fetoprotein; DCP: Des-γ-carboxy prothrombin; TBil: Total bilirubin; ALT: Alanine aminotransferase; HR: Hazard ratio.

Table 4 Multivariate Cox regression analysis

Factor	Beta	SE	P value	HR	Lower	Upper
Treatment plan	0.671	0.229	0.003b	1.957	1.249	3.068
Cirrhosis	0.744	0.318	0.019a	2.104	1.127	3.927
Tumor diameter	0.675	0.323	0.037a	1.963	1.042	3.699
Child-Pugh score	-0.809	0.274	0.003b	0.445	0.260	0.761
Pre-treatment AFP	0.004	0.002	0.006b	1.004	1.001	1.007
Pre-treatment AFP-L3	0.004	0.001	0.002b	1.004	1.002	1.007

^aP < 0.05.

^bP < 0.01.

AFP: Alpha-fetoprotein; HR: Hazard ratio.