Luan RG, Liu MD, Deng ZF, Lu CL, Yu ML, Zhang MY, Liu R, An R, Yao YL, Guo DB, Zhang YX, Zhao L. Correlations of the expression of Cx43, SCFFBXW7, p-cyclin E1 (Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in colon cancer tissues. World J Gastrointest Oncol 2025; 17(1): 98410 [DOI: 10.4251/wjgo.v17.i1.98410]
Corresponding Author of This Article
Lei Zhao, MD, PhD, Attending Doctor, Surgeon, Department of Orthopaedics, Air Force Hospital of Eastern Theater, Anhui Medical University, No. 1 Changfu Road, Malu Road, Nanjing 230032, Jiangsu Province, China. 18742583975@163.com
Research Domain of This Article
Pathology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 98410 Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.98410
Table 1 Expressions of proteins in colon cancer tissues (n = 38)
Cx43
SCFFBW7
p-cyclin E1 (Ser73)
p-cyclin E1 (Thr77)
p-cyclin E1 (Thr395)
Positive
29
29
25
2
21
Negative
9
9
13
36
17
Positive rate (%)
76.32
76.32
65.79
5.26
55.26
Table 2 Correlation analysis between FBXW7 and p-cyclin E1 (Ser73) in colon cancer tissues
FBXW7
Ser73(-)
Ser73(+)
Ser73(++)
Ser73(+++)
r
P value
-
7
2
0
0
0.703
0.001
+
5
7
2
2
++
1
1
4
2
+++
0
0
2
3
Table 3 Correlation analysis between FBXW7 and p-cyclin E1 (Thr77) in colon cancer tissues
FBXW7
Thr77(-)
Thr77(+)
Thr77(++)
Thr77(+++)
r
P value
-
9
0
0
0
0.079
0.638
+
15
0
0
0
++
9
0
0
0
+++
5
0
0
0
Table 4 Correlation analysis between FBXW7 and p-cyclin E1 (Thr395) in colon cancer tissues
FBXW7
Thr395(-)
Thr395(+)
Thr395(++)
Thr395(+++)
r
P value
-
5
3
0
0
0.415
0.010
+
8
5
2
1
++
4
2
3
0
+++
0
1
2
2
Table 5 Correlation analysis between Cx43 and FBXW7 in colon cancer tissues
Cx43
FBXW7(-)
FBXW7(+)
FBXW7(++)
FBXW7(+++)
r
P value
-
6
3
0
0
0.749
0.001
+
3
6
3
0
++
0
6
4
1
+++
0
0
2
5
Table 6 Correlation analysis between Cx43 and p-cyclin E1 (Ser73) in colon cancer tissues
Cx43
Ser73(-)
Ser73(+)
Ser73(++)
Ser73(+++)
r
P value
-
8
1
0
0
0.667
0.001
+
2
7
2
1
++
3
2
3
3
+++
0
0
3
3
Table 7 Correlation analysis between Cx43 and p-cyclin E1 (Thr77) in colon cancer tissues
Cx43
Thr77(-)
Thr77(+)
Thr77(++)
Thr77(+++)
r
P value
-
9
0
0
0
0.262
0.112
+
12
0
0
0
++
11
0
0
0
+++
6
0
0
0
Table 8 Correlation analysis between Cx43 and p-cyclin E1(Thr395) in colon cancer tissues
Cx43
Thr395(-)
Thr395(+)
Thr395(++)
Thr395(+++)
r
P value
-
5
3
0
1
0.457
0.004
+
8
3
1
0
++
4
4
3
0
+++
0
1
3
2
Citation: Luan RG, Liu MD, Deng ZF, Lu CL, Yu ML, Zhang MY, Liu R, An R, Yao YL, Guo DB, Zhang YX, Zhao L. Correlations of the expression of Cx43, SCFFBXW7, p-cyclin E1 (Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in colon cancer tissues. World J Gastrointest Oncol 2025; 17(1): 98410