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©The Author(s) 2025.
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 100204
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.100204
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.100204
Characteristics | All CRC, n = 277 | Propensity-matched CRC, n = 207 |
Ascending colon | 55 (11.4) | 42 (8.7) |
Transverse colon | 11 (2.3) | 8 (1.7) |
Descending colon | 18 (3.7) | 14 (2.9) |
Sigmoid colon | 68 (14) | 49 (10.1) |
Rectum | 125 (25.8) | 94 (19.4) |
T. stage | ||
T1 | 28 (5.8) | 23 (4.8) |
T2 | 36 (7.4) | 25 (5.2) |
T3 | 196 (40.5) | 148 (30.6) |
T4 | 17 (3.5) | 11 (2.3) |
N. stage | ||
N0 | 156 (32.2) | 119 (24.6) |
N1 | 71 (14.7) | 53 (11) |
N2 | 50 (10.3) | 35 (7.2) |
M. stage | ||
M0 | 251 (51.9) | 190 (39.3) |
M1 | 26 (5.4) | 17 (3.5) |
Blood vessels | ||
- | 199 (41.1) | 150 (31) |
+ | 78 (16.1) | 57 (11.8) |
Nerve | ||
- | 210 (43.4) | 159 (32.9) |
+ | 67 (13.8) | 48 (9.9) |
Size, median (IQR) | 4 (3, 5) | 4 (3, 5) |
Differentiation | ||
Low grade | 94 (19.4) | 69 (14.3) |
High grade | 183 (37.8) | 138 (28.5) |
Stage | ||
I | 55 (11.4) | 41 (8.2) |
II | 95 (19.6) | 72 (14.9) |
III | 100 (20.7) | 73 (15.1) |
IV | 27 (5.6) | 19 (3.9) |
Characteristics | All patients | Propensity-matched patients | ||||
Control, n = 1034 | CRC, n = 277 | P value | Controls, n = 207 | CRC, n = 207 | P value | |
Age in years | 66.53 ± 7.41 | 66.54 ± 10.91 | 0.989 | 68.89 ± 5.53 | 65.58 ± 11.12 | 0.053 |
Sex as male/female | 466/568 | 176/101 | < 0.001 | 96/111 | 122/85 | 0.010 |
Hypertension in % | 10.25 | 43.68 | < 0.001 | 34.78 | 28.99 | 0.206 |
Diabetes in % | 1.64 | 14.80 | < 0.001 | 7.73 | 5.80 | 0.434 |
Coronary heart disease or Cerebral infarction in % | 0.48% | 12.64 | < 0.001 | 2.24 | 2.24 | 1 |
BMI | 25.09 ± 5.25 | 23.78 ± 3.27 | < 0.001 | 24.40 ± 3.77 | 23.84 ± 3.29 | 0.106 |
WBC as × 109/L | 6.49 ± 1.58 | 6.16 ± 1.84 | 0.003 | 6.64 ± 1.66 | 6.14 ± 1.84 | 0.004 |
RBC as × 109/L | 4.70 ± 0.43 | 4.19 ± 0.61 | < 0.001 | 4.66 ± 0.40 | 4.21 ± 0.58 | < 0.001 |
Hb in g/L | 143.23 ± 13.24 | 120.63 ± 25.73 | < 0.001 | 141.89 ± 12.61 | 121.47 ± 25.08 | < 0.001 |
PLT as × 109/L | 216.94 ± 52.78 | 240.59 ± 83.72 | < 0.001 | 224.17 ± 51.69 | 240.94 ± 78.97 | 0.011 |
ALT in U/L | 21.36 ± 7.75 | 18.50 ± 31.60 | 0.144 | 20.33 ± 7.63 | 17.65 ± 18.27 | 0.057 |
AST in U/L | 21.40 ± 12.65 | 21.24 ± 35.77 | 0.908 | 19.36 ± 12.60 | 19.73 ± 11.93 | 0.758 |
TC in mmol/L | 4.81 ± 0.98 | 4.23 ± 0.97 | < 0.001 | 4.80 ± 1.02 | 4.34 ± 0.94 | < 0.001 |
TG in mmol/L | 1.65 ± 1.21 | 1.35 ± 0.73 | < 0.001 | 1.84 ± 1.87 | 1.33 ± 0.65 | < 0.001 |
HDL-C in mmol/L | 1.38 ± 0.36 | 1.14 ± 0.32 | < 0.001 | 1.41 ± 0.41 | 1.17 ± 0.32 | < 0.001 |
LDL-C in mmol/L | 3.10 ± 0.87 | 2.66 ± 0.85 | < 0.001 | 3.01 ± 0.86 | 2.76 ± 0.83 | 0.003 |
UA in mmol/L | 319.84 ± 77.29 | 315.62 ± 81.37 | 0.430 | 324.75 ± 80.97 | 312.42 ± 78.70 | 0.121 |
SCR in mmoI/L | 74.63 ± 22.89 | 76.67 ± 21.08 | 0.190 | 78.29 ± 26.10 | 73.84 ± 19.89 | 0.056 |
CEA in ng/mL | 1.91 ± 1.51 | 35.67 ± 176.15 | 0.002 | 2.80 ± 1.54 | 26.62 ± 95.89 | 0.001 |
CA199 in U/mL | 11.26 ± 7.64 | 176.16 ± 1013.41 | 0.009 | 12.00 ± 8.77 | 159.62 ± 929.85 | 0.027 |
AI | 2.65 ± 1.05 | 35.67 ± 176.15 | 0.002 | 2.64 ± 1.35 | 2.89 ± 1.14 | 0.042 |
TyG index | 8.81 ± 0.58 | 8.58 ± 0.55 | < 0.001 | 8.86 ± 0.59 | 8.55 ± 0.51 | < 0.001 |
Indicator | AUC | 95%CI | Cut-off value | P value |
TC | 0.6243 | 0.5709-0.6777 | 4.325 | < 0.0001 |
TG | 0.6406 | 0.5873-0.6938 | 1.345 | < 0.0001 |
HDL-C | 0.6802 | 0.6292-0.7311 | 1.165 | < 0.0001 |
LDL-C | 0.5812 | 0.5263-0.6360 | 3.035 | 0.0043 |
CEA | 0.6429 | 0.5882-0.6976 | 5.15 | < 0.0001 |
CA19-9 | 0.5623 | 0.5057-0.6190 | 23.225 | 0.0305 |
AI | 0.5748 | 0.5199-0.6298 | 2.655 | 0.0085 |
TyG index | 0.6572 | 0.6048-0.7097 | 8.635 | < 0.0001 |
CEA + CA199 + TYG index | 0.7525 | 0.7052-0.7997 | < 0.0001 |
- Citation: Hu RH, Yan DY, Zhang KH, Zhang D, Cui XM, Jiang XH, Zhang S. Lipid levels and insulin resistance markers in patients with colorectal cancer: Propensity score matching analysis. World J Gastrointest Oncol 2025; 17(1): 100204
- URL: https://www.wjgnet.com/1948-5204/full/v17/i1/100204.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v17.i1.100204