Inflammation-related markers and prognosis of alpha-fetoprotein producing gastric cancer

Table 1 Analysis of risk factors affecting overall survival of alpha-fetoprotein+ patients

Variables	Univariate analysis		Multivariate Cox analysis
	Log-Rank χ2	P value	HR (95%CI)	P value
Sex (female/male)	2.557	0.11
Age (< 60/≥ 60 years)	0.418	0.518
AFP (< 20-54/54-485/≥ 485 ng/mL)	6.424	0.040
Tumor location1 (A/B/C/D)	1.906	0.592
Tumor size (< 5/≥ 5 cm)	1.292	0.256
Differentiation2 (a/b/c/d)	3.208	0.361
Lymphatic metastasis (no/yes)	9.926	0.002
Liver metastasis (no/yes)	13.134	< 0.001	3.551 (1.715-7.351)	0.001
Extrhepatic metastasis (no/yes)	1.320	0.251
Time of liver metastasis (Simultaneous/heterochronous)	2.570	0.109
TNM stage (I-II/III-IV)	12.481	< 0.001	2.825 (1.102-7.243)	0.031
T stage (1-2/3-4)	2.138	0.144
N stage (0-1/2-3)	2.829	0.093
Vascular invasion (no/yes)	2.988	0.084
Nerve invasion (no/yes)	0.031	0.86
Treatment3 (CT/CO/SO/S + C/others)	20.773	< 0.001		0.002
			3.650 (0.799-16.672)	0.095
			1.367 (0.273-6.840)	0.703
			1.261 (0.271-5.855)	0.768
			0.687 (0.135-3.510)	0.652
NLR (< 2.70/≥ 2.70)	14.091	< 0.001
PLR (< 156.31/≥ 156.31)	10.928	0.001
MLR (< 0.46/≥ 0.46)	15.772	< 0.001
SII (< 755.75/≥ 755.75)	17.164	< 0.001	2.889 (1.444-5.782)	0.003
SIRI (< 1.36/≥ 1.36)	11.259	0.001
PNI (< 42.18/≥ 42.18)	13.876	< 0.001	2.327 (1.143-4.735)	0.020

¹A, B, C and D represented respectively “upper 1/3 of the stomach”, “middle 1/3 of the stomach”, “lower 1/3 of the stomach” and “≥ 2 sites are involved”.

²a, b, c and d represented respectively “high/high-medium differentiated adenocarcinoma”, “medium/medium-low differentiated adenocarcinoma”, “low/ undifferentiated adenocarcinoma” and “hepatoid adenocarcinoma”.

³“CT”, “CO”, “SO”, “S + C” represented “conservative treatment”, “chemotherapy only”, “surgery only”, “chemotherapy plus surgery” respectively.

The time of liver metastasis was only counted for patients with liver metastasis. Tumor size, T stage, N stage, vascular nerve and nerve invasion were counted for patients who underwent gastric surgery. OS: Overall survival; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; MLR: Monocyte-to-lymphocyte ratio; SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index; PNI: Prognostic nutritional index; AFP: Alpha-fetoprotein; TNM: tumor-node-metastasis.