Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer

Table 1 Relationship between CASC19 and clinicopathologic characteristics

Patient-related factors	CASC19		χ2	P value
	Low (n = 36)	High (n = 36)
Gender			0.250	0.617
Male	25	23
Female	11	13
Age (years)			2.724	0.099
< 60	15	22
≥ 60	21	14
Tumor sizes			14.629	< 0.001
< 5 cm	29	13
≥ 5 cm	7	23
Differentiation grade			1.787	0.181
Poor	24	29
Well	12	7
Tumor location			5.077	0.079
Upper	3	3
Middle	9	18
Lower	24	15
N stage			19.505	< 0.001
N0	22	4
N1-N3	14	32
T stage			9.000	0.003
T1-T2	18	6
T3-T4	18	30

Table 2 Risk factors for prognosis in patients with gastric cancer

Variable	Univariate analysis, HR (95%CI)	P value	Multivariate analysis, HR (95%CI)	P value
CASC19	5.986 (2.854-12.555)	< 0.001	2.478 (1.071-5.736)	0.034
Gender	1.056 (0.544-2.048)	0.872
Age	1.407 (0.756-2.619)	0.282
Differentiation grade	0.965 (0.471-1.976)	0.922
Tumor size	9.438 (4.397-20.257)	< 0.001	2.969 (1.189-7.415)	0.02
Tumor location	0.736 (0.466-1.164)	0.19
TNM (I, II/III)	10.293 (3.642-29.089)	< 0.001	4.122 (1.243-13.672)	0.021

Table 3 Relationship between the HMGA2 and clinicopathologic characteristics

Patient-related factors	HMGA2		χ2	P value
	Low (n = 22)	High (n = 22)
Gender			0.109	0.741
Male	16	15
Female	6	7
Age (years)			1.467	0.226
< 60	10	14
≥ 60	12	8
Tumor sizes			0.910	0.340
< 5 cm	16	13
≥ 5 cm	6	9
Differentiation grade			3.536	0.060
Poor	11	17
Well	11	5
N stage			9.821	0.002
N0	13	3
N1-N3	9	19
T stage			4.956	0.026
T1-T2	11	4
T3-T4	11	18