Microvascular structural changes in esophageal squamous cell carcinoma pathology according to intrapapillary capillary loop types under magnifying endoscopy

Table 1 Clinical and histopathological characteristics

Parameters	Value
Total number of patients	26
Sex as male/female	20/6
Mean age in yr (range)	62 (49-77)
Total number of lesions	35
Tumor invasion depth cases, N/IN, T1a-EP/LPM, T1a-MM/T1b-SM1, T1b-SM2	9, 12, 7, 7
JES classification types A, B1, B2, B3	9, 8, 10, 8

JES: Japan Esophageal Society; N/IN: Normal or intraepithelial neoplasia.

Table 2 Pathological data of intrapapillary capillary loops for Types A, B1, B2, B1/B2, and B3

Parameter	Type A	Type B1	Type B2	Type B1/B2	Type B3	P value
Short caliber of IPCL in μm	7.4 ± 1.43	13.31 ± 4.65	17.52 ± 5.03	15.65 ± 5.26	21.35 ± 7.55	< 0.001
Long caliber of IPCL in μm	13.87 ± 3.18	26.50 ± 9.54	38.76 ± 17.72	33.31 ± 15.78	53.38 ± 20.46	< 0.001
Area of IPCL in μm²	92.48 ± 34.80	333.05 ± 224.94	601.59 ± 489.61	482.24 ± 413.84	1088.11 ± 625.45	< 0.001
Density in μm²	693.84 ± 424.44	3183.89 ± 2527.81	4194.07 ± 2922.58	3745.10 ± 2775.48	5220.32 ± 3509.80	< 0.001
X in μm	122.30 ± 12.74	274.73 ± 25.90	295.15 ± 17.71	286.07 ± 110.61	256.55 ± 17.23	< 0.001
Y in μm	317.22 ± 24.81	363.52 ± 30.71	373.56 ± 21.13	369.10 ± 131.05	331.18 ± 18.80	> 0.05
Location on X/Y	0.38 ± 0.11	0.75 ± 0.10	0.79 ± 0.08	0.77 ± 0.10	0.77 ± 0.10	< 0.001

Data are mean ± standard deviation. IPCL: Intrapapillary capillary loop; SD: Standard deviation; X: Apical distance from the vertex of the intrapapillary capillary loop to the basement membrane; Y: Epithelial layer thickness.