Analysis of vascular thrombus and clinicopathological factors in prognosis of gastric cancer: A retrospective cohort study

Table 1 Relationship between vascular cancer thrombi and other clinical and pathological factors, n (%)

Clinical pathological factors	Cases	Vascular cancer thrombus		χ2	P value
		Negative	Positive
Gender
Male	448	307 (68.5)	141 (31.5)	46	0.83
Female	173	117 (67.6)	56 (32.4)
Age (years)
≤ 60	305	210 (68.9)	95 (31.1)	0.092	0.76
> 60	316	214 (67.7)	102 (32.3)
Degree of differentiation
Well differentiated	131	110 (84.0)	21 (16.0)	18.876	90.0
Poorly differentiated	490	314 (64.1)	176 (35.9)
Tumor diameter (cm)
≤ 4	334	247 (74.0)	87 (26.0)	10.746	< 0.01
> 4	287	177 (61.7)	110 (38.3)
Borrmann typing
Early gastric cancer	143	132 (92.3)	11 (7.7)	56.480	90.0
Type I	25	18 (72.0)	7 (28.0)
Type II	10	9 (90.0)	1 (10.0)
Type III	397	241 (60.7)	156 (39.3)
Type IV	46	24 (52.2)	22 (47.8)
Invasion depth
T1	143	132 (92.3)	11 (7.7)	78.397	< 0.01
T2	103	81 (78.6)	22 (21.4)
T3	19	17 (89.5)	2 (10.5
T4	356	194 (54.5)	162 (45.5)
Number of lymph node metastases
NO	254	212 (83.5)	42 (16.5)	99.640	90.0
N1	120	97 (80.8)	23 (19.2)
N2	119	67 (56.3)	52 (43.7
N3	128	48 (37.5	80 (62.5)
TNM staging
I	195	173 (88.7)	22 (11.3)	83.903	< 0.01
II	134	103 (76.9)	31 (23.1)
III	292	148 (50.7)	144 (49.3)
Number of detected lymph nodes
≥ 16	335	220 (65.7)	115 (34.3)	2.280	0.13
< 16	286	204 (71.3)	82 (28.7)

Table 2 Binary logistic regression analysis of the influencing factors of vascular cancer thrombus

Clinical pathological factors	β	Wald	OR	95%CI	P value
Degree of differentiation	0.770	8.111	2.161	1.272-3.671	< 0.01
Invasion depth	1.254	29.495	3.504	2.229-5.510	< 0.01
Lymph node metastasis	0.731	11.004	2.078	1.349-3.201	< 0.01

Table 3 Trend of influencing factors of vascular thrombus in patients with gastric cancer by χ² test

Clinical pathological factors	χ2	R	P value
Degree of differentiation	18.845	0.174	< 0.01
Invasion depth	73.914	0.345	< 0.01
Lymph node metastasis	92.693	0.387	< 0.01

Table 4 Multivariate analysis of prognostic factors in 621 postoperative gastric cancer patients

Clinical pathological factors	β	Wald	OR	95%CI	P value
Age > 60 years old	0.268	3.834	1.307	1.000-1.709	< 0.05
Tumor diameter > 4 cm	0.515	12.005	1.673	1.251-2.239	< 0.01
Vascular cancer thrombus positive	0.413	8.561	1.512	1.146-1.994	< 0.01
TNM II stage	1.087	13.431	2.966	1.658-5.305	< 0.01
TNM III stage	1.853	47.009	6.380	3.756-10.836	< 0.01