Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer

Table 1 Basic characteristics of the study population, n (%)

	NC (n = 8)	AA (n = 19)	CRC (n = 16)
Sex
Male	4 (50.0)	12 (63.2)	11 (68.7)
Female	4 (50.0)	7 (36.8)	5 (31.3)
Age (yr), mean ± SD	54.5 ± 10.5	57.1 ± 11.6	59.6 ± 10.1
Diameter size (cm), mean ± SD	-	2.4 ± 1.0	4.7 ± 1.5
Location
Proximal colon	-	8 (42.1)	4 (25.0)
Distal colon	-	7 (36.8)	4 (25.0)
Rectum	-	4 (21.1)	8 (50.0)
Stage distribution
Early stage (I/II)	-	-	8 (50.0)
Late stage (III/IV)	-	-	8 (50.0)

AA: Advanced adenoma; CRC: Colorectal cancer; NC: Normal control.

Table 2 Functions of potential protein biomarkers

Biomarkers	Protein names	Uniprot ID	Biological process	Molecular function
DIAPH1	Protein diaphanous homolog 1	O60610	Actin cytoskeleton organization, cytoskeleton organization	Actin binding, RNA binding, signaling receptor binding
VASP	Vasodilator-stimulated phosphoprotein	P50552	Actin cytoskeleton organization	Actin binding, Cadherin binding
RAB11B	Ras-related protein Rab-11B	Q15907	Constitutive secretory pathway, endocytic recycling	Cadherin binding, GTP binding
LBP	Lipopolysaccharide-binding protein	P18428	Acute-phase response	Lipopeptide binding
SAR1A	GTP-binding protein SAR1a	Q9NR31	COPII-coated vesicle cargo loading	GTP binding, GTPase activity
TUBGCP5	Gamma-tubulin complex component 5	Q96RT8	Cytoplasmic microtubule organization	Gamma-tubulin binding, microtubule binding
DOK3	Docking protein 3	Q7L591	Ras protein signal transduction	-