Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma

Table 1 Biomarkers for predicting hepatic artery infusion chemotherapy prognosis

Biomarker	PFS HR (95%CI)	OS HR (95%CI)	ORR HR (95%CI)	ORR (%)	Ref.
NLR	1.363 (1.008-1.843)	1.492 (1.106-2.012)	1.918 (1.092-3.369)	37.6	[31]
NLR	1.984 (1.111-3.545)			24.3	[39]
DCP	2.460 (1.434-4.220)	3.097 (1.728-5.551)		24.3	[39]
AFP DCP		2.17 (1.23-3.92)		51.9	[52]
		1.9 (1.06-3.42)		56.4	[52]
VEGF		2.42 (1.33-4.38)		35.2	[43]
Serum transferrin		1 (0.132-0.603)		46.9	[47]
IL-28B		1.720 (1.072-2.759)	2.620(1.124-6.107)	51.9	[73]

NLR: Neutrophil to lymphocyte ratio; DCP: Des-γ-carboxy prothrombin; AFP: Alpha-fetoprotein; VEGF: Vascular endothelial growth factor; IL-28B: Interleukin-28B; PFS: Progression-free survival; OS: Overall survival; ORR: objective response rate; CI: Confidence interval.

Table 2 C-index of the nomogram and conventional staging system[53]

Staging system	Training cohort (n = 308)			Validation cohort (n = 155)
	C-index	95%CI	P value1	C-index	95%CI	P value1
The nomogram	0.710	0.674–0.746	NA	0.716	0.664–0.768	NA
BCLC staging system	0.562	0.523–0.602	< 0.001	0.613	0.558–0.668	0.005
HKLC staging system	0.626	0.594–0.658	< 0.001	0.659	0.616–0.702	0.043
CIS	0.631	0.596–0.666	< 0.001	0.658	0.610–0.707	0.044
AJCC eighth edition	0.637	0.603–0.672	< 0.001	0.634	0.588–0.680	0.015
JIS score	0.619	0.582–0.655	< 0.001	0.638	0.587–0.689	0.017
Okuda classification	0.634	0.600–0.668	< 0.001	0.631	0.585–0.676	0.011

¹P value was calculated according to the difference between the nomogram and other staging systems.

BCLC: Barcelona Clinic Liver Cancer; HKLC: Hong Kong Liver Cancer; CIS: China integrated score; AJCC: American Joint Committee on Cancer; JIS: Japan Integrated Staging; HR: Hazard rate; CI: Confidence interval; NA: Not available. Citation: Mei J, Lin WP, Shi F, Wei W, Liang JB, Shi M, Zheng L, Li SH, Guo RP. Prognostic nomogram predicting survival of patients with unresectable hepatocellular carcinoma after hepatic arterial infusion chemotherapy. Eur J Radiol 2021; 142: 109890. Copyright © 2021, The Authors. Published by Elsevier. The authors have obtained the permission for table using (Supplementary material).