Mapping the intellectual structure and emerging trends for the application of nanomaterials in gastric cancer: A bibliometric study

Table 1 The top 10 productive countries/regions

Rank	Country	Publications	Citations
1	China	1007	25279
2	USA	232	7621
3	Iran	135	1740
4	South Korea	121	2733
5	India	113	2072
6	Japan	106	3605
7	Saudi Arabia	53	627
8	England	50	1753
9	Germany	47	1501
10	Italy	46	1200

Table 2 The top 10 productive institutions

Rank	Institution	Country	Publications	Citations
1	Shanghai Jiao Tong University	China	94	3981
2	Nanjing Medical University	China	59	1273
3	Nanjing University	China	55	1589
4	Islamic Azad University	Iran	55	474
5	Southeast University	China	49	2020
6	Chinese Academy of Sciences	China	47	1368
7	Fudan University	China	44	856
8	Sun Yat-Sen University	China	34	671
9	Southern Medical University	China	30	576
10	Yonsei University	South Korea	27	634

Table 3 The top 20 productive authors

Rank	Author	Total publications	Total citations	Per citations
1	Da-Xiang Cui	47	2693	57
2	Nong-Yue He	29	1434	49
3	Chun-Lei Zhang	27	1915	71
4	Kan Wang	19	1137	60
5	Bao-Rui Liu	19	447	24
6	Chao Li	15	731	49
7	Qin Liu	15	277	18
8	Yan Deng	14	1451	104
9	Guo Gao	14	1070	76
10	Jing Wang	14	235	17
11	Qian Zhang	12	400	33
12	Wei Li	12	166	14
13	Ali Salehzadeh	12	44	4
14	Zhi-Yang Li	11	375	34
15	Rutian Li	11	297	27
16	Yong-Min Huh	11	292	27
17	Seungjoo Haam	11	265	24
18	Xiao Zhi	10	583	58
19	Fei Pan	10	533	53
20	Li Li	10	160	16

Table 4 The top 10 productive journals

Rank	Journal	IF (2021)	Total publications	Total citations
1	International Journal of Nanomedicine	7.033	64	2026
2	Journal of Nanoscience and Nanotechnology	/	44	746
3	Journal of Biomedical Nanotechnology	3.641	33	994
4	Nanoscience and Nanotechnology Letters	/	30	273
5	International Journal of Pharmaceutics	6.51	28	649
6	Biomaterials	15.304	28	2078
7	International Journal of Biological Macromolecules	8.025	25	535
8	Scientific Reports	4.997	24	720
9	ACS Applied Materials & Interfaces	10.383	23	636
10	RSC Advances	4.036	22	399

Table 5 The top 10 highest cited articles

Rank	Title	Journal	Impact Index Per Article	Citations	Average Citations	Publication year	Ref.
1	Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling	Proceedings of the National Academy of Sciences	22.9	345	22	2007	[13]
2	Folic acid-conjugated Silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy	Biomaterials	26.7	333	28	2011	[79]
3	Diagnosis and Classification of 17 Diseases from 1404 Subjects via Pattern Analysis of Exhaled Molecules	ACS Nano	35.7	285	48	2017	[80]
4	Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression	Journal of Cancer Research and Clinical Oncology	33.6	225	38	2017	[81]
5	Photosensitizer-conjugated magnetic nanoparticles for in vivo simultaneous magnetofluorescent imaging and targeting therapy	Biomaterials	16.5	222	19	2011	[82]
6	A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation	British Journal of Cancer	13.1	219	14	2007	[83]
7	Defined factors induce reprogramming of gastrointestinal cancer cells	Proceedings of the National Academy of Sciences	15.6	217	17	2010	[84]
8	Synthesis of novel biodegradable and self-assembling methoxy poly (ethylene glycol)–palmitate nanocarrier for curcumin delivery to cancer cells	Acta Biomaterialia	11.3	196	13	2008	[85]
9	Ultrasensitive Silicon Nanowire for Real-World Gas Sensing: Noninvasive Diagnosis of Cancer from Breath Volatolome	Nano Letters	12.9	172	22	2015	[86]
10	Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light	Biosensors and Bioelectronics	12.4	171	14	2011	[56]

Table 6 Clusters of the top 100 keywords

Cluster	Keywords	Counts	Rank	Cluster	Keywords	Counts	Rank
1	Nanoparticles	389	1	2	DNA	42	35
1	Drug-delivery	193	3	2	Stem-cells	42	36
1	Cancer	187	5	2	Northern jiangsu	41	40
1	Delivery	182	6	2	Toxicity	40	43
1	In-vitro	182	7	2	Gastric-cancer risk	39	44
1	Therapy	134	9	2	Diagnosis	35	53
1	Release	104	11	2	Antioxidant	34	55
1	In-vivo	76	14	2	Oxidative stress	33	61
1	Chemotherapy	65	17	2	Mechanism	32	63
1	Doxorubicin	64	18	2	Quantum dots	32	64
1	Paclitaxel	55	23	2	Infection	32	65
1	Design	49	27	2	Complexes	30	70
1	Stability	48	28	2	Graphene oxide	29	72
1	Bioavailability	44	30	2	Model	28	74
1	Drug	44	31	2	Proteins	28	75
1	Combination	41	38	2	Binding	27	77
1	Acid	41	39	2	Gold nanorods	27	78
1	System	40	41	2	Sensitive detection	26	81
1	Tumor	40	42	2	Iron-oxide nanoparticles	25	87
1	Efficacy	38	45	2	Silver nanoparticles	25	88
1	Tumors	37	47	2	Induction	24	91
1	5-fluorouracil	36	48	2	Rapid detection	23	95
1	Chitosan	36	49	2	Nanocomposites	23	96
1	Size	36	50	2	Biomedical applications	22	98
1	Controlled-release	35	52	2	Green synthesis	22	99
1	Micelles	34	54	3	Gastric-cancer	219	2
1	Cisplatin	33	57	3	Expression	190	4
1	Nanocarriers	33	58	3	Cells	142	8
1	Pharmacokinetics	33	59	3	Breast-cancer	104	12
1	Cancer-cells	33	60	3	Growth	90	13
1	Carriers	32	62	3	Identification	73	15
1	Liposomes	31	67	3	Metastasis	64	19
1	Antitumor-activity	30	68	3	Carcinoma	60	20
1	Formulation	30	69	3	Proliferation	57	22
1	Oral delivery	29	71	3	Inhibition	55	24
1	Systems	28	73	3	Resistance	52	26
1	Polymeric micelles	26	80	3	Activation	45	29
1	Co-delivery	25	84	3	Lung-cancer	44	33
1	Microspheres	25	85	3	Gene	43	34
1	Inflammation	25	86	3	Colorectal-cancer	42	37
1	Permeability	24	90	3	Protein	38	46
1	Polymeric nanoparticles	23	92	3	Invasion	36	51
1	Multidrug-resistance	23	93	3	Adenocarcinoma	34	56
1	Ph	23	94	3	Survival	32	66
1	Absorption	22	97	3	Gene-expression	28	76
2	Apoptosis	124	10	3	Pathway	27	79
2	Magnetic nanoparticles	66	16	3	Micrornas	26	82
2	Gold nanoparticles	57	21	3	Progression	26	83
2	Cytotoxicity	54	25	3	Migration	25	89
2	Mechanisms	44	32	3	Differentiation	22	100