Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

Table 1 Association of Schlafen-11 methylation and clinical factors in esophageal squamous cell carcinoma

Clinical factor	No.	SLFN11 methylation status		P value
		Unmethylated, n = 749 (74.37%)	Methylated, n = 258 (25.62%)
Age (yr)				0.512
< 60	317	240	77
≥ 60	690	509	181
Gender				0.823
Male	677	505	172
Female	330	244	86
Smoking				0.883
No	562	417	145
Yes	445	332	113
Alcohol consumption				0.743
No	730	545	185
Yes	277	204	73
Tumor size (cm)				0.012a
≤ 4	633	454	179
> 4	374	295	79
Differentiation				0.002b
Well	173	147	26
Moderate	526	383	143
Poor	308	219	89
TNM stage				0.567
I + II	531	391	140
III + IV	476	358	118
Lymph node metastasis				0.973
Negative	526	391	135
Positive	481	358	123

^aP < 0.05.

^bP < 0.01.

P values are obtained from χ² test. SLFN11: Schlafen-11.