Albumin–bilirubin grade as a predictor of survival in hepatocellular carcinoma patients with thrombocytopenia

Table 1 Basic characteristics of hepatocellular carcinoma patients

Variables	Overall
Etiology: HBV/others	118/17
Sex: Male/female	113/22
Age (yr)	53.7 ± 9.8
Age: ≥ 60/< 60 yr	37/98
ALT (U/L)	38.0 (26.0-63.2)
AST (U/L)	40.0 (29.4-63.0)
TBIL (µmol/L)	14.8 (11.8-20.1)
ALB (g/L)	38.9 (34.1-42.0)
PLT (109/L)	80 (62-90)
AFP: ≥ 400/< 400 ng/mL	43/92
Ascites: Yes/no	29/106
Tumor size: > 5/≤ 5 cm	64/71
Tumor number: Multiple/single	20/115
Vascular invasion: Yes/no	15/120
Cirrhosis: Yes/no	89/46
CP grade (A/B)	113/22
ALBI score	-2.53 (-2.76 to -2.15)
ALBI grade (1/2-3)	59/76
PALBI score	-2.65 (-2.82 to -2.44)
PALBI grade (1/2-3)	89/46

Data were expressed as median (interquartile range), mean ± SD, or No. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; ALB: Albumin; PLT: Platelet count; AFP: α-fetoprotein; CP: Child–Pugh; ALBI: Albumin–bilirubin; PALBI: Platelet–albumin–bilirubin; HBV: Hepatitis B virus.

Table 2 Univariate analysis of factors associated with overall survival and recurrence-free survival of hepatocellular carcinoma patients

Variables	OS		RFS
	HR (95%CI)	P value	HR (95%CI)	P value
Etiology (HBV/others)	1.908 (0.755-4.824)	0.172	1.449 (0.687-3.058)	0.330
Sex (male/female)	1.510 (0.728-3.129)	0.268	1.245 (0.649-2.389)	0.509
Age (> 60/≤ 60 years)	0.598 (0.297-1.204)	0.150	0.553 (0.292-1.050)	0.070
ALT (> 40/≤ 40 U/L)	1.250 (0.710-2.198)	0.441	1.272 (0.778-2.083)	0.786
AST (> 40/≤ 40 U/L)	1.027 (0.585-1.802)	0.927	1.092 (0.672-1.770)	0.916
TBIL (> 17/≤ 17 µmol/L)	1.411 (0.800-2.487)	0.234	1.156 (0.527-1.418)	0.566
ALB (< 35/≥ 35 g/L)	1.029 (0.566-1.871)	0.924	1.074 (0.635-1.818)	0.789
AFP (≥ 400/< 400 ng/mL)	1.881 (1.054-3.357)	0.032a	1.863 (1.128-3.077)	0.015a
Ascites (yes/no)	1.692 (0.908-3.152)	0.098	1.788 (1.054-3.033)	0.031a
Tumor size (> 5/≤ 5 cm)	1.919 (1.080-3.411)	0.026a	2.189 (1.330-3.602)	0.002a
Tumor number (multiple/single)	1.265 (0.645-2.481)	0.494	1.161 (0.620-2.175)	0.641
Vascular invasion (yes/no)	2.384 (1.181-4.812)	0.015a	2.509 (1.306-4.820)	0.006a
Cirrhosis (yes/no)	1.006 (0.563-1.796)	0.984	1.127 (0.668-1.899)	0.654
CP grade (B/A)	1.279 (0.654-2.504)	0.472	0.998 (0.533-1.868)	0.994
ALBI grade (2/1)	2.704 (1.448-5.047)	0.002a	1.768 (1.066-2.932)	0.027a
PALBI grade (2-3/1)	1.666 (0.945-2.940)	0.078	1.250 (0.758-2.060)	0.382

^aP < 0.05: Statistically significant values.

OS: Overall survival; RFS: Recurrence-free survival; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; ALB: Albumin; PLT: Platelet count; AFP: α-fetoprotein; CP: Child–Pugh; ALBI: Albumin–bilirubin; PALBI: Platelet–albumin–bilirubin; HR: Hazard ratio; HBV: Hepatitis B virus.