NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

Table 1 Basic information of patients and its relationship with nicotinamide adenine dinucleotide phosphate oxidase 4

Factor	Category	Total	High NOX4 (N = 52)	Low NOX4 (N = 30)	P value
Age (yr)		64.46 ± 12.6	64.79 ± 12.38	63.9 ± 13.18	0.765
Gender	Female	49 (60)	31 (60)	18 (60)	1.000
	Male	33 (40)	21 (40)	12 (40)
Tumor location	Left colon or rectum	51 (62)	35 (67)	16 (53)	0.307
	Right colon	31 (38)	17 (33)	14 (47)
Histopathology	Well differentiated	31 (38)	17 (33)	14 (47)	0.373
	Moderately differentiated	32 (39)	23 (44)	9 (30)
	Poorly differentiated	19 (23)	12 (23)	7 (23)
pT	T1	17 (21)	11 (21)	6 (20)	0.357
	T2	26 (32)	13 (25)	13 (43)
	T3	24 (29)	17 (33)	7 (23)
	T4	15 (18)	11 (21)	4 (13)
pN	N0	45 (55)	25 (48)	20 (67)	0.233
	N1	26 (32)	18 (35)	8 (27)
	N2	11 (13)	9 (17)	2 (7)
pM	M0	82 (100)	52 (100)	30 (100)	1.000
	M1	0	0	0
pStage	Stage I	19 (23)	5 (10)	14 (47)	< 0.001
	Stage II	24 (29)	19 (37)	5 (17)
	Stage III	39 (48)	28 (54)	11 (37)

NOX4: Nicotinamide adenine dinucleotide phosphate oxidase 4.

Table 2 Three genes obtained from the intersection of differential genes and prognostic genes in colorectal cancer

Gene symbol	Log FC	HR	Function
NOX4	2.868242	1.197865	Constitutive NADPH oxidase which generates superoxide intracellularly
BGN	2.368592	1.259598	May be involved in collagen fiber assembly
PPAPDC1A	2.345055	1.126713	Magnesium-independent phospholipid phosphatase with broad substrate specificity

NOX4: Nicotinamide adenine dinucleotide phosphate oxidase 4; NADPH: Nicotinamide adenine dinucleotide phosphate; FC: Fold change; HR: Hazard ratio.