Should we perform sigmoidoscopy for colorectal cancer screening in people under 45 years?

Table 1 Baseline characteristics of the study participants

Characteristics	All independent cases for research, n = 3053	Adenomatous polyps, n = 2652	Adenomatous polyps with high-grade neoplasia n = 106
Age (yr, mean ± SD)	38.33 ± 5.15	38.41 ± 5.08	37.28 ± 5.51
Sex [n (%)]
Male	2138 (70.0)	1842 (69.5)	72 (67.9)
Female	915 (30.0)	810 (30.5)	34 (32.1)

Table 2 The prevalence of adenomatous polyps in the left and right colon

	Entire colon	Both left-and right colon	Left colon	Right colon	OR (95%CI) of left vs right colon	P value of left vs right colon
Adenomatous polyps [n (%)]	2652 (86.9)	298 (0.9)	1679 (55.0)	1271 (41.6)	1.7 (1.6-2.4)	0.0001
Adenomatous polyps with high-grade neoplasia [n (%)]	106 (3.5)	4 (0.1)	82 (2.7)	28 (0.9)	3.0 (2.0-4.6)	0.0001

Table 3 The adenomatous polyps in entire colon for screening and post-polypectomy surveillance in the following 1–3 yr

The numbers of polyps in follow-up cases, n = 327	Adenomatous polyps, n = 216	Non-adenomatous Polyps, n = 111	OR (95%CI)	P value
1-3 polyps [n (%)]	170 (52.0)	104 (31.8)	0.3 (0.1-0.6)	0.0004
> 3 polyps [n (%)]	46 (14.1)	7 (2.1)