Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

Table 1 The ingredients of Poria cocos

ID	Phytochemical name	OB	DL
MOL000273	16alpha-Hydroxydehydrotrametenolic acid	30.93	0.81
MOL000274	3β-hydroxylanosta-7,9(11),24-trien-21-oic acid	24.92	0.8
MOL000275	Trametenolic acid	38.71	0.8
MOL000276	7,9(11)-dehydropachymic acid	35.11	0.81
MOL000277	Tumulosic acid	15.95	0.81
MOL000278	Beta-glucan	0.73	0.7
MOL000279	Cerevisterol	37.96	0.77
MOL000280	Dehydrotumulosic acid	31.07	0.82
MOL000281	Dimethyl L-malate	8.59	0.03
MOL000282	Stellasterol	43.51	0.72
MOL000283	Ergosterol peroxide	40.36	0.81
MOL000284	L-uridine	23.4	0.11
MOL000285	(2R)-2-[(5R,10S,13R,14R,16R,17R)-16-hydroxy-3-keto-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-5-isopropyl-hex-5-enoic acid	38.26	0.82
MOL000286	β-amyrin acetate	9.11	0.74
MOL000287	3-beta-hydroxy-24-methylene-8-lanostene-21-oic acid	38.7	0.81
MOL000288	Pachyman	0.45	0.68
MOL000289	Pachymic acid	33.63	0.81
MOL000290	Poricoic acid A	30.61	0.76
MOL000291	Poricoic acid B	30.52	0.75
MOL000292	Poricoic acid C	38.15	0.75
MOL000293	Poricoic acid D	22.38	0.78
MOL000294	Poricoic acid DM	29.32	0.78
MOL000295	Alexandrin	20.63	0.63
MOL000296	Hederagenin	36.91	0.75
MOL000297	Tumulosic acid	29.88	0.81
MOL000298	Ergosterol	14.29	0.72
MOL000299	Trimethyl citrate	67.61	0.07
MOL000300	Dehydroeburicoic acid	44.17	0.83
MOL000301	2-lauroleic acid	31.42	0.04
MOL000302	Undekansaeure	30.14	0.03
MOL000303	Caprylic acid	16.4	0.02
MOL000304	Ethyl glucoside	16.4	0.02
MOL000305	Lauric acid	23.59	0.04
MOL000069	Palmitic acid	19.3	0.1

OB: Oral bioavailability; DL: Drug-likeliss.