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©The Author(s) 2023.
World J Gastrointest Oncol. Aug 15, 2023; 15(8): 1342-1348
Published online Aug 15, 2023. doi: 10.4251/wjgo.v15.i8.1342
Published online Aug 15, 2023. doi: 10.4251/wjgo.v15.i8.1342
Drug delivery system | Structure | Advantage | Disadvantage | Common types |
Polymer | Shell-core structure | Hydrophobic, high and precise drug concentration with low side effects | Poor water solubility | Bioadhesive micelles, active targeting micelles, etc. |
Liposome | Lipid bilayer microvesicle carriers | Diversity, targeting, lymphatic targeting, liver protection, etc. | High cost | Unilamellar liposomes, multilamellar liposomes, liposome gel, etc. |
Microsphere | Shell-core structure | Covering bad odors, avoiding incompatible combinations, high stability and safety | Relatively short duration and relatively large drug dosage | Conventional injection microspheres, occlusive microspheres, magnetic microspheres, etc. |
Nanoparticle (NPs) | Shell-core structure | Amphiphilic, controllable loading effect, long half-life, etc. | Low solubility of inorganic NPs | Lipophilic NPs, nanocapsules, nanospheres, and inorganic NPs, etc. |
Nanogel | Intramolecular cross-linked polymer | Anti-fouling, antibacterial, targeting, small size, easily penetrating cells, etc. | No obvious disadvantage | pH-responsive hydrogels, hyaluronic acid hydrogels, copolymer hydrogels |
Cyclodextrin | Bimolecular complex | High water solubility, low toxicity, high stability | No obvious disadvantage | α-cyclodextrin, β-cyclodextrin, partially methylated-β-cyclodextrin, etc. |
Cancer type | Study category | No. | Dosage regimen | Results |
Colorectal cancer[37] | Phase II, randomized double-blind study | 22 | Capecitabine 825 mg/m2, Bid; curcumin 4 g, Bid | Curcumin does not increase the remission rate of patients |
Esophageal cancer[38] | Controlled trial | 1 | Group A: 20 µg/mL curcumin-containing culture; Group B: 2 µg/mL Vincristine-containing culture; Combined group: 20 µg/mL curcumin+2 µg/mL vincristine-containing culture | Curcumin reverses multidrug resistance of esophageal cancer cells |
Metastatic colorectal cancer[39] | Phase IIa, randomized controlled trial | 28 | Control group: FOLFOX1; Research Group: FOLFOX + curcumin 2 g/d | Curcumin plus FOLFOX regimen significantly improves chemotherapy tolerance and safety |
Advanced gastric cancer[40] | Randomized controlled trial | 56 | Control group: FOLFOX; Research Group: FOLFOX + curcumin 25 µmol/L, 1/d | Curcumin plus FOLFOX regimen significantly improves clinical remission rate and reduces toxic side effects |
- Citation: Wu X, Yang Y. Research progress on drug delivery systems for curcumin in the treatment of gastrointestinal tumors. World J Gastrointest Oncol 2023; 15(8): 1342-1348
- URL: https://www.wjgnet.com/1948-5204/full/v15/i8/1342.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i8.1342