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©The Author(s) 2023.
World J Gastrointest Oncol. Jun 15, 2023; 15(6): 1086-1095
Published online Jun 15, 2023. doi: 10.4251/wjgo.v15.i6.1086
Published online Jun 15, 2023. doi: 10.4251/wjgo.v15.i6.1086
Table 1 General clinical characteristics of the subjects
Characteristics | CRC (training) | HC (training) | CRC (validation) | HC (validation) |
Number | 101 | 195 | 62 | 100 |
Age, yr | ||||
Mean | 58 | 53 | 57 | 55 |
Range | 29-81 | 33-57 | 33-74 | 34-67 |
Sex | ||||
Male | 60 | 116 | 37 | 64 |
Female | 41 | 79 | 25 | 36 |
TNM stage | ||||
T1 | 11 | 11 | ||
T2 | 27 | 21 | ||
T3 | 44 | 7 | ||
T4 | 19 | 23 |
Table 2 Comparison of the four markers between the healthy control group and colorectal cancer group
Indicator | HC (n = 195) | CRC (n = 101) | F | Sig | P value |
NDUFB7 | 1.54 (0.94, 2.31) | 2.10 (1.29, 3.08) | 0.15 | 0.70 | 0.60 |
CAMK1D | 9.71 (6.38, 18.25) | 70.39 (35.26, 155.57) | 34.24 | < 0.01 | < 0.01 |
PIK3CD | 297.11 (232.76, 374.69) | 333.22 (259.40, 417.90) | 10.47 | < 0.01 | 0.03 |
PSEN2 | 5.48 (4.04, 7.21) | 8.69 (6.00, 11.67) | 5.89 | 0.02 | < 0.01 |
Table 3 Evaluation of the diagnostic value of three markers exhibiting statically significant differences between the healthy control group and colorectal cancer group
Indicator | AUC | SD | P value | 95%CI | |
Lower | Upper | ||||
CAMK1D | 0.935 | 0.015 | < 0.001 | 0.907 | 0.964 |
PSEN2 | 0.740 | 0.031 | < 0.001 | 0.678 | 0.801 |
PIK3CD | 0.582 | 0.036 | 0.021 | 0.511 | 0.653 |
Table 4 Univariate and multivariate logistic regression of CAMK1D and PSEN2
Indicator | B | SE | Wals | P value | Exp (B) | 95%CI | |
Lower | Upper | ||||||
CAMK1D | 0.560 | 0.137 | 16.781 | < 0.001 | 1.751 | 1.339 | 2.289 |
PIK3CD | 0.071 | 0.011 | 41.382 | < 0.001 | 1.074 | 1.051 | 1.097 |
Table 5 Multivariate logistic regression of CAMK1D and PSEN2
Indicator | B | SE | Wals | P value | Exp (B) | 95%CI | |
Lower | Upper | ||||||
CAMK1D | 0.125 | 0.039 | 10.400 | 0.001 | 1.133 | 1.050 | 1.222 |
PIK3CD | -0.002 | 0.004 | 0.208 | 0.648 | 0.998 | 0.990 | 1.006 |
- Citation: Cui Y, Zhang LJ, Li J, Xu YJ, Liu MY. Diagnostic value of circular free DNA for colorectal cancer detection. World J Gastrointest Oncol 2023; 15(6): 1086-1095
- URL: https://www.wjgnet.com/1948-5204/full/v15/i6/1086.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i6.1086