Cancerous inhibitor of protein phosphatase 2A enhances chemoresistance of gastric cancer cells to oxaliplatin

Table 1 Association between the expression of cancerous inhibitor of protein phosphatase 2A and clinicopathological features in patients with gastric cancer

Prognostic variables	Number	Expression of CIP2A		χ2	P value
		Low	High
Sex				1.766	0.184
Male	71	27	44
Female	37	19	18
Age, yr				0.175	0.676
< 60	68	30	38
≥ 60	40	16	24
Tumor location				0.097	0.756
Proximal + middle	37	15	22
Distal	71	31	40
Histological grade				0.001	0.973
G1 + G2	26	11	15
G3	82	35	47
Tumor size in cm				5.975	0.015a
< 5	84	41	43
≥ 5	24	5	19
T stage				5.472	0.019a
T1–T2	36	21	15
T3–T4	72	25	47
N stage				12.428	0.000a
N0	47	29	18
N1–N3	61	17	44
TNM stage				5.168	0.023a
I + II	69	35	34
III + IV	39	11	28

^aP < 0.05.

CIP2A: Cancerous inhibitor of protein phosphatase 2A; G: Grade; N: Node; T: Tumor; TNM: Tumor Node Metastasis.

Table 2 Univariate and multivariate analyses of overall survival in patients with gastric cancer

Prognostic variables	Univariate analysis			Multivariate analysis
	Hazard ratio	95% confidence interval	P value	Hazard ratio	95% confidence interval	P value
Sex	0.99	0.584–1.679	0.97	-	-	-
Age	1.372	0.820–2.296	0.229	-	-	-
Tumor location	0.925	0.545–1.569	0.772	-	-	-
Histological grade	0.736	0.420–1.288	0.283	-	-	-
Tumor size	2.417	1.399–4.176	0.004a	0.87	0.504–1.504	0.619
T stage	3.184	1.687–6.007	0.000a	2.651	1.295–5.423	0.008a
N stage	2.034	1.196–3.457	0.009a	1.414	0.709–2.818	0.325
TNM stage	1.946	1.168–3.243	0.011a	0.912	0.469–1.774	0.786
CIP2A expression	2.319	1.288–3.927	0.003a	1. 802	1.012–3.210	0.046a

^aP < 0.05.

T: Tumor; N: Node; TNM: Tumor Node Metastasis; CIP2A: Cancerous inhibitor of protein phosphatase 2A.

Table 3 Univariate and multivariate analyses of progression-free survival in patients with gastric cancer

Prognostic variables	Univariate analysis			Multivariate analysis
	Hazard ratio	95% confidence interval	P value	Hazard ratio	95% confidence interval	P value
Sex	0.973	0.574–1.650	0.919	-	-	-
Age	1.363	0.814–2.281	0.239	-	-	-
Tumor location	0.913	0.538–1.548	0.735	-	-	-
Histological grade	0.73	0.417–1.278	0.27	-	-	-
Tumor size	2.43	1.407–4.197	0.004a	0.869	0.504–1.499	0.614
T stage	3.15	1.669–5.943	0.000a	2.644	1.294–5.420	0.009a
N stage	2.044	1.202–3.476	0.008a	1.451	0.728–2.891	0.29
TNM stage	1.917	1.150–3.194	0.013a	0.88	0.452–1.713	0.88
CIP2A expression	2.309	1.282–3.911	0.003a	1.821	1.021–3.247	0.042a

^aP < 0.05.

T: Tumor; N: Node; TNM: Tumor Node Metastasis; CIP2A: Cancerous inhibitor of protein phosphatase 2A.