Retrospective Study
Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 265-277
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.265
Table 1 Clinical characteristics of patients with gastric cardia adenocarcinoma
Variables
Cases, n (%)

Gender
Female95420.9
Male360779.1
Age at diagnosis (yr)
< 60171737.6
≥ 60284462.4
Family history
Negative336673.8
Positive119526.2
Cigarette smoking
No216647.5
Yes239552.5
Alcohol consumption
No320670.3
Yes135529.7
Differentiation
Well1332.9
Moderate203944.7
Poor238952.4
T status
T1711.6
T23086.8
T3304466.7
T4113825.0
Lymph node metastasis
Negative163735.9
Positive292464.1
Staging
Early stage1914.2
Advanced stage437095.8
Table 2 The difference of E-cadherin protein expression in normal tissue, dysplasia and gastric cardia adenocarcinoma
Lesion type
Total
E-cadherin protein expression
χ2
P value
n
Positive, n (%)
Negative, n (%)
Normal208208 (100.0)0 (0)47.439< 0.001
DYS156145 (93.0)11 (7.0)
GCA45613836 (84.1)725 (15.9)
Table 3 Association of E-cadherin expression with clinicopathological features in patients with gastric cardia adenocarcinoma
VariablesTotal
E-cadherin protein expression
χ2
P value
n
Positive, n (%)
Negative, n (%)
Gender4.6450.031
Female954824 (86.4)130 (13.6)
Male36073012 (83.5)595 (16.5)
Age at diagnosis (yr)0.709> 0.05
< 6017171434 (83.5)283 (16.5)
≥ 6028442402 (84.5)442 (15.5)
Family history1.018> 0.05
Negative33662820 (83.8)546 (16.2)
Positive11951016 (85.0)179 (15.0)
Cigarette smoking1.408> 0.05
No21661841 (85.0)325 (15.0)
Yes23952005 (83.7)390 (16.3)
Alcohol consumption0.011> 0.05
No32062706 (84.4)500 (15.6)
Yes13551142 (84.3)213 (15.7)
Differentiation14.2590.001
Well133123 (92.5)10 (7.5)
Moderate20391742 (85.4)297 (14.6)
Poor23891971 (82.5)418 (17.5)
T status22.490< 0.001
pT17163 (88.7)8 (11.3)
pT2308278 (90.3)30 (9.7)
pT330442580 (84.8)464 (15.2)
pT41138915 (80.4)223 (19.6)
Lymph node metastasis0.481> 0.05
Negative16371385 (84.6)252 (15.4)
Positive29242451 (83.8)473 (16.2)
Staging10.9410.001
Early stage191177 (92.7)14 (7.3)
Advanced stage43703659 (83.7)711 (16.3)
Table 4 Univariate and multivariate analyses of survival of patients with gastric cardia adenocarcinoma
Variables
Univariate analysis
Multivariate analysis
HR
95%CI
P value
HR
95%CI
P value
Gender> 0.05
Female1
Male1.0630.979-1.153
Age at diagnosis (yr)< 0.001< 0.001
< 6011
≥ 601.3351.246-1.4311.3521.262-1.449
Family history> 0.05
Negative1
Positive1.0600.983-1.143
Cigarette smoking> 0.05
No1
Yes1.0040.929-1.084
Alcohol consumption> 0.05
No1
Yes0.9470.869-1.031
Differentiation< 0.001< 0.001
Well11
Moderate1.3161.067-1.6231.2341.000-1.522
Poor1.7911.454-2.2061.4801.199-1.827
T status< 0.001< 0.001
pT111
pT21.9161.289-2.8491.6041.078-2.387
pT32.8291.949-4.1072.0741.426-3.018
pT43.3902.328-4.9362.272 1.555-3.320
Lymph node metastasis< 0.001< 0.001
Negative11
Positive1.9521.815-2.0991.8051.676-1.944
E-cadherin0.0030.026
Positive11
Negative1.1441.048-1.2481.1041.012-1.206